Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain

Brendon E. Cook; Sangram Nag; Ryosuke Arakawa; Edward Yin-Shiang Lin; Nancy Stratman; Kevin Guckian; Heike Hering; Mukesh Lulla; Jinkuk Choi; Cristian Salinas; Nathan E. Genung; Anton Forsberg Morén; Martin Bolin; Giulia Boscutti; Christophe Plisson; Laurent Martarello; Christer Halldin; Maciej A. Kaliszczak

doi:10.2967/jnumed.122.265225

Research ArticleBasic Science Investigation

Open Access

Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain

Brendon E. Cook, Sangram Nag, Ryosuke Arakawa, Edward Yin-Shiang Lin, Nancy Stratman, Kevin Guckian, Heike Hering, Mukesh Lulla, Jinkuk Choi, Cristian Salinas, Nathan E. Genung, Anton Forsberg Morén, Martin Bolin, Giulia Boscutti, Christophe Plisson, Laurent Martarello, Christer Halldin and Maciej A. Kaliszczak

Journal of Nuclear Medicine October 2023, 64 (10) 1588-1593; DOI: https://doi.org/10.2967/jnumed.122.265225

Brendon E. Cook

1Biogen, Cambridge, Massachusetts;

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Sangram Nag

2Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden;

3Stockholm County Council, Stockholm, Sweden; and

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Ryosuke Arakawa

2Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden;

3Stockholm County Council, Stockholm, Sweden; and

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Edward Yin-Shiang Lin

1Biogen, Cambridge, Massachusetts;

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Nancy Stratman

1Biogen, Cambridge, Massachusetts;

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Kevin Guckian

1Biogen, Cambridge, Massachusetts;

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Heike Hering

1Biogen, Cambridge, Massachusetts;

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Mukesh Lulla

1Biogen, Cambridge, Massachusetts;

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Jinkuk Choi

1Biogen, Cambridge, Massachusetts;

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Cristian Salinas

1Biogen, Cambridge, Massachusetts;

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Nathan E. Genung

1Biogen, Cambridge, Massachusetts;

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Anton Forsberg Morén

2Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden;

3Stockholm County Council, Stockholm, Sweden; and

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Martin Bolin

2Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden;

3Stockholm County Council, Stockholm, Sweden; and

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Giulia Boscutti

4Invicro, London, United Kingdom

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Christophe Plisson

4Invicro, London, United Kingdom

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Laurent Martarello

1Biogen, Cambridge, Massachusetts;

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Christer Halldin

2Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden;

3Stockholm County Council, Stockholm, Sweden; and

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Maciej A. Kaliszczak

1Biogen, Cambridge, Massachusetts;

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October 1, 2023

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Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain

Journal of Nuclear Medicine Oct 2023, 64 (10) 1588-1593; DOI: 10.2967/jnumed.122.265225

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Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain

Journal of Nuclear Medicine Oct 2023, 64 (10) 1588-1593; DOI: 10.2967/jnumed.122.265225

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Keywords

OGA
O-GlcNAcase
Alzheimer
PET

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