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Research ArticleBRIEF COMMUNICATION

Feasibility of 99mTc-MIP-1404 for SPECT/CT Imaging and Subsequent PSMA-Radioguided Surgery in Early Biochemically Recurrent Prostate Cancer: A Case Series of 9 Patients

Daniel Koehler, Markus Sauer, Susanne Klutmann, Ivayla Apostolova, Wencke Lehnert, Lars Budäus, Sophie Knipper and Tobias Maurer
Journal of Nuclear Medicine January 2023, 64 (1) 59-62; DOI: https://doi.org/10.2967/jnumed.122.263892
Daniel Koehler
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;
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Markus Sauer
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;
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Susanne Klutmann
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;
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Ivayla Apostolova
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;
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Wencke Lehnert
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;
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Lars Budäus
2Martini-Klinik Prostate Cancer Center, University Hospital Hamburg–Eppendorf, Hamburg, Germany; and
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Sophie Knipper
2Martini-Klinik Prostate Cancer Center, University Hospital Hamburg–Eppendorf, Hamburg, Germany; and
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Tobias Maurer
2Martini-Klinik Prostate Cancer Center, University Hospital Hamburg–Eppendorf, Hamburg, Germany; and
3Department of Urology, University Hospital Hamburg–Eppendorf, Hamburg, Germany
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  • FIGURE 1.
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    FIGURE 1.

    68Ga-PSMA I&T PET/CT (A and C) and 99mTc-MIP-1404 SPECT/CT (B and D) images of patient 8 (maximum-intensity projections [A and B] and coronal fusion images [C and D]; slice thickness, 3 mm) with PSMA-positive lymph node metastases adjacent to left internal iliac artery (arrows).

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    TABLE 1.

    Lesion-Based Case Characteristics

    PET/CTSPECT/CTRGS
    Patient no.Lesion locationSADLADSUVmaxSUVmax to BGVisual scoreSUVmaxSUVmax to BGVisual scoreCounts ex vivo (max)Counts ex vivo (max to BG)Histology (PCa)
    1IIR prox.358.21721.23.705418Yes
    IIR dist.4515.331.739.428.825418Yes
    2CIL prox.223.6611.23.5011No
    CIL dist.4710.517.430.92.8088Yes
    IIL prox.456.911.321.13.1088Yes
    IIL int.345.28.621.23.5011No
    IIL dist.4612.620.733.29.411717Yes
    3CIL prox.13205.719.6317.9100.533010Yes
    CIL int.1924930.8328.5160.233110Yes
    CIL dist.11284.716213.877.833010Yes
    4IIL353.410.220.83.803010Yes
    5Pararectal6133.49.326.726.823518Yes
    6IIL3517.235.831.14.608930Yes
    7EIL111551114.63112.9407.63354118Yes
    8IIL prox.2511.442.23846.3310435Yes
    IIL dist.5515.256.3314.886.1312943Yes
    9Presacral228.916.120.84.50116Yes
    • SAD = lesion short axis in mm; LAD = lesion long axis in mm; max = maximum; BG = background; IIR = internal iliac right; prox. = proximal; dist. = distal; CIL = common iliac left; IIL = internal iliac left; int. = intermediate; EIL = external iliac left.

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Journal of Nuclear Medicine: 64 (1)
Journal of Nuclear Medicine
Vol. 64, Issue 1
January 1, 2023
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Feasibility of 99mTc-MIP-1404 for SPECT/CT Imaging and Subsequent PSMA-Radioguided Surgery in Early Biochemically Recurrent Prostate Cancer: A Case Series of 9 Patients
Daniel Koehler, Markus Sauer, Susanne Klutmann, Ivayla Apostolova, Wencke Lehnert, Lars Budäus, Sophie Knipper, Tobias Maurer
Journal of Nuclear Medicine Jan 2023, 64 (1) 59-62; DOI: 10.2967/jnumed.122.263892

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Feasibility of 99mTc-MIP-1404 for SPECT/CT Imaging and Subsequent PSMA-Radioguided Surgery in Early Biochemically Recurrent Prostate Cancer: A Case Series of 9 Patients
Daniel Koehler, Markus Sauer, Susanne Klutmann, Ivayla Apostolova, Wencke Lehnert, Lars Budäus, Sophie Knipper, Tobias Maurer
Journal of Nuclear Medicine Jan 2023, 64 (1) 59-62; DOI: 10.2967/jnumed.122.263892
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Keywords

  • prostate cancer
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