Research ArticleClinical (Oncology: Other)
CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody
Michael D. Farwell, Raymond F. Gamache, Hasan Babazada, Matthew D. Hellmann, James J. Harding, Ron Korn, Alessandro Mascioni, William Le, Ian Wilson, Michael S. Gordon, Anna M. Wu, Gary A. Ulaner, Jedd D. Wolchok, Michael A. Postow and Neeta Pandit-Taskar
Journal of Nuclear Medicine May 2022, 63 (5) 720-726; DOI: https://doi.org/10.2967/jnumed.121.262485
Michael D. Farwell
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
Raymond F. Gamache
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
Hasan Babazada
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
Matthew D. Hellmann
3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York;
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Medicine, Weill Cornell Medical College, New York, New York;
James J. Harding
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Medicine, Weill Cornell Medical College, New York, New York;
Ron Korn
6Imaging Endpoints, Scottsdale, Arizona;
Alessandro Mascioni
7ImaginAb, Inc., Inglewood, California;
William Le
7ImaginAb, Inc., Inglewood, California;
Ian Wilson
7ImaginAb, Inc., Inglewood, California;
Michael S. Gordon
8HonorHealth Research Institute, Scottsdale, Arizona;
Anna M. Wu
7ImaginAb, Inc., Inglewood, California;
9Department of Molecular Imaging and Therapy, Beckman Research Institute of the City of Hope, Duarte, California;
Gary A. Ulaner
10Molecular Imaging and Therapy, Hoag Family Cancer Institute, Newport Beach, California;
Jedd D. Wolchok
3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York;
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Medicine, Weill Cornell Medical College, New York, New York;
11Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York;
Michael A. Postow
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Medicine, Weill Cornell Medical College, New York, New York;
Neeta Pandit-Taskar
3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York;
12Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and
13Department of Radiology, Weill Cornell Medical College, New York, New York
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Journal of Nuclear Medicine
Vol. 63, Issue 5
May 1, 2022
CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody
Michael D. Farwell, Raymond F. Gamache, Hasan Babazada, Matthew D. Hellmann, James J. Harding, Ron Korn, Alessandro Mascioni, William Le, Ian Wilson, Michael S. Gordon, Anna M. Wu, Gary A. Ulaner, Jedd D. Wolchok, Michael A. Postow, Neeta Pandit-Taskar
Journal of Nuclear Medicine May 2022, 63 (5) 720-726; DOI: 10.2967/jnumed.121.262485
CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody
Michael D. Farwell, Raymond F. Gamache, Hasan Babazada, Matthew D. Hellmann, James J. Harding, Ron Korn, Alessandro Mascioni, William Le, Ian Wilson, Michael S. Gordon, Anna M. Wu, Gary A. Ulaner, Jedd D. Wolchok, Michael A. Postow, Neeta Pandit-Taskar
Journal of Nuclear Medicine May 2022, 63 (5) 720-726; DOI: 10.2967/jnumed.121.262485
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