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Research ArticleClinical (Oncology: Lung)

First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients

Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang and Nan Li
Journal of Nuclear Medicine April 2022, 63 (4) 536-542; DOI: https://doi.org/10.2967/jnumed.121.262045
Xin Zhou
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jinquan Jiang
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Xue Yang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China; and
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Teli Liu
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jin Ding
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Sridhar Nimmagadda
3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Martin G. Pomper
3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Hua Zhu
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jun Zhao
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China; and
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Zhi Yang
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Nan Li
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Journal of Nuclear Medicine: 63 (4)
Journal of Nuclear Medicine
Vol. 63, Issue 4
April 1, 2022
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First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang, Nan Li
Journal of Nuclear Medicine Apr 2022, 63 (4) 536-542; DOI: 10.2967/jnumed.121.262045

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First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang, Nan Li
Journal of Nuclear Medicine Apr 2022, 63 (4) 536-542; DOI: 10.2967/jnumed.121.262045
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Cited By...

  • Recent Advances in Radiotracers Targeting Novel Cancer-Specific Biomarkers in China: A Brief Overview
  • Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers
  • Noninvasive Monitoring of Immunotherapy in Lung Cancer by Lymphocyte Activation Gene 3 PET Imaging of Tumor-Infiltrating Lymphocytes
  • Non-invasive PD-L1 quantification using [18F]DK222-PET imaging in cancer immunotherapy
  • Molecular imaging to support cancer immunotherapy
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Keywords

  • PD-(L)1
  • PET/CT
  • immune checkpoint inhibitor
  • non–small cell lung cancer
  • pembrolizumab
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