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Research ArticleClinical (Oncology: Lung)

First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients

Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang and Nan Li
Journal of Nuclear Medicine April 2022, 63 (4) 536-542; DOI: https://doi.org/10.2967/jnumed.121.262045
Xin Zhou
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jinquan Jiang
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Xue Yang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China; and
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Teli Liu
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jin Ding
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Sridhar Nimmagadda
3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Martin G. Pomper
3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Hua Zhu
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Jun Zhao
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China; and
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Zhi Yang
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Nan Li
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
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Article Information

vol. 63 no. 4 536-542
DOI 
https://doi.org/10.2967/jnumed.121.262045
PubMed 
34326125

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 31, 2021
  • Revision received June 29, 2021
  • Published online March 31, 2022.

Article Versions

  • previous version (July 29, 2021 - 14:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Xin Zhou*,1,
  2. Jinquan Jiang*,1,
  3. Xue Yang*,2,
  4. Teli Liu1,
  5. Jin Ding1,
  6. Sridhar Nimmagadda3,
  7. Martin G. Pomper3,
  8. Hua Zhu1,
  9. Jun Zhao2,
  10. Zhi Yang1 and
  11. Nan Li1
  1. 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital & Institute, Beijing, China;
  2. 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China; and
  3. 3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
  1. For correspondence or reprints, contact Nan Li (rainbow6283{at}sina.com), Zhi Yang (pekyz{at}163.com), Hua Zhu (zhuhuananjing{at}163.com), and Jun Zhao (ohjerry{at}163.com).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (4)
Journal of Nuclear Medicine
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April 1, 2022
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First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang, Nan Li
Journal of Nuclear Medicine Apr 2022, 63 (4) 536-542; DOI: 10.2967/jnumed.121.262045

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First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang, Nan Li
Journal of Nuclear Medicine Apr 2022, 63 (4) 536-542; DOI: 10.2967/jnumed.121.262045
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Keywords

  • PD-(L)1
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  • non–small cell lung cancer
  • pembrolizumab
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