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Table of Contents

April 1, 2022; Volume 63,Issue 4

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 12A;

Discussions with Leaders

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    Leadership in Patient Advocacy
    Josh Mailman and Thomas A. Hope
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 497-499; DOI: https://doi.org/10.2967/jnumed.122.263989

The State of The Art

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    Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development
    Tyler J. Bradshaw, Ronald Boellaard, Joyita Dutta, Abhinav K. Jha, Paul Jacobs, Quanzheng Li, Chi Liu, Arkadiusz Sitek, Babak Saboury, Peter J.H. Scott, Piotr J. Slomka, John J. Sunderland, Richard L. Wahl, Fereshteh Yousefirizi, Sven Zuehlsdorff, Arman Rahmim and Irène Buvat
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 500-510; DOI: https://doi.org/10.2967/jnumed.121.262567

Hot Topics

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    Virtual Biopsy: Just an AI Software or a Medical Procedure?
    Jacob M. Murray, Bodo Wiegand, Boris Hadaschik, Ken Herrmann and Jens Kleesiek
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 511-513; DOI: https://doi.org/10.2967/jnumed.121.263749

Continuing Education

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    Principles of Tracer Kinetic Analysis in Oncology, Part II: Examples and Future Directions
    Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot and David A. Mankoff
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 514-521; DOI: https://doi.org/10.2967/jnumed.121.263519

Oncology

  • Clinical

    • Impact of <sup>18</sup>F-FET PET/MRI on Clinical Management of Brain Tumor Patients
      You have access
      Impact of 18F-FET PET/MRI on Clinical Management of Brain Tumor Patients
      Cornelia Brendle, Caroline Maier, Benjamin Bender, Jens Schittenhelm, Frank Paulsen, Mirjam Renovanz, Constantin Roder, Salvador Castaneda-Vega, Ghazaleh Tabatabai, Ulrike Ernemann and Christian la Fougère
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 522-527; DOI: https://doi.org/10.2967/jnumed.121.262051
    • 
    Phase I Trial of <sup>99m</sup>Tc-(HE)<sub>3</sub>-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer
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      Phase I Trial of 99mTc-(HE)3-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer
      Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Eugeniy Garbukov, Anzhelika Vorobyeva, Anna Orlova, Liubov Tashireva, Jens Sörensen, Roman Zelchan, Anna Medvedeva, Sergey Deyev and Vladimir Tolmachev
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 528-535; DOI: https://doi.org/10.2967/jnumed.121.262542
    • First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
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      First-in-Humans Evaluation of a PD-L1–Binding Peptide PET Radiotracer in Non–Small Cell Lung Cancer Patients
      Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang and Nan Li
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 536-542; DOI: https://doi.org/10.2967/jnumed.121.262045
    • PET-Based Staging Is Cost-Effective in Early-Stage Follicular Lymphoma
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      PET-Based Staging Is Cost-Effective in Early-Stage Follicular Lymphoma
      Andrea C. Lo, Lyndon P. James, Anca Prica, Adam Raymakers, Stuart Peacock, Melody Qu, Alex V. Louie, Kerry J. Savage, Laurie H. Sehn, David Hodgson, Joanna C. Yang, Hans T.T. Eich, Andrew Wirth and M.G. Myriam Hunink
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 543-548; DOI: https://doi.org/10.2967/jnumed.121.262324
    • Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer
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      Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer
      Erwin Woff, Lisa Salvatore, Federica Marmorino, Dario Genovesi, Gabriela Critchi, Thomas Guiot, Lieveke Ameye, Francesco Sclafani, Alain Hendlisz and Patrick Flamen
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 549-555; DOI: https://doi.org/10.2967/jnumed.120.245357
    • BRIEF COMMUNICATION

      • 
    Hepatic Artery Injection of <sup>131</sup>I-Metuximab Combined with Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Prospective Nonrandomized, Multicenter Clinical Trial
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        Hepatic Artery Injection of 131I-Metuximab Combined with Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Prospective Nonrandomized, Multicenter Clinical Trial
        Hui Chen, Gang Nan, Ding Wei, Ren-You Zhai, Ming Huang, Wu-Wei Yang, Bao-Cai Xing, Xu Zhu, Hai-Feng Xu, Xiao-Dong Wang, Xiao-Yong Zhang, Bao-Rang Zhu, Peng Liu, Guang Cao, Song Gao, Chun-Yi Hao, Ren-Jie Yang, Jian-Hai Guo, Xin Zhang, Kun Gao, Kun Wang, Jian-Feng Wang, Zi-Yu Li, Lin-Zhong Zhu, Rong Ding, Jing Li, Ling Zhao, Yu-Jun Shao, Hai-Chun Liu, Jie-Lai Xia, Ling Wang, Ling-Min Kong, Zhi-Nan Chen and Huijie Bian
        Journal of Nuclear Medicine April 1, 2022, 63 (4) 556-559; DOI: https://doi.org/10.2967/jnumed.121.262136

Theranostics

  • Clinical

    • FEATURED ARTICLE OF THE MONTH

      • <sup>177</sup>Lu-PSMA-617 and Idronoxil in Men with End-Stage Metastatic Castration-Resistant Prostate Cancer (LuPIN): Patient Outcomes and Predictors of Treatment Response in a Phase I/II Trial
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        177Lu-PSMA-617 and Idronoxil in Men with End-Stage Metastatic Castration-Resistant Prostate Cancer (LuPIN): Patient Outcomes and Predictors of Treatment Response in a Phase I/II Trial
        Sarennya Pathmanandavel, Megan Crumbaker, Andrew O. Yam, Andrew Nguyen, Christopher Rofe, Elizabeth Hovey, Craig Gedye, Edmond M. Kwan, Christine Hauser, Arun A. Azad, Peter Eu, Andrew J. Martin, Anthony M. Joshua and Louise Emmett
        Journal of Nuclear Medicine April 1, 2022, 63 (4) 560-566; DOI: https://doi.org/10.2967/jnumed.121.262552
    • 
    A Comprehensive Assessment of <sup>68</sup>Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients
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      A Comprehensive Assessment of 68Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients
      Monica Abghari-Gerst, Wesley R. Armstrong, Kathleen Nguyen, Jeremie Calais, Johannes Czernin, David Lin, Namasvi Jariwala, Melissa Rodnick, Thomas A. Hope, Jason Hearn, Jeffrey S. Montgomery, Ajjai Alva, Zachery R. Reichert, Daniel E. Spratt, Timothy D. Johnson, Peter J.H. Scott and Morand Piert
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 567-572; DOI: https://doi.org/10.2967/jnumed.121.262412
    • 
    An <sup>89</sup>Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients
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      An 89Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients
      Felix Dietlein, Carsten Kobe, Sergio Muñoz Vázquez, Thomas Fischer, Heike Endepols, Melanie Hohberg, Manuel Reifegerst, Bernd Neumaier, Klaus Schomäcker, Alexander E. Drzezga and Markus Dietlein
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 573-583; DOI: https://doi.org/10.2967/jnumed.121.262290
  • Basic

    • First In Vivo and Phantom Imaging of Cyclotron-Produced <sup>133</sup>La as a Theranostic Radionuclide for <sup>225</sup>Ac and <sup>135</sup>La
      Open Access
      First In Vivo and Phantom Imaging of Cyclotron-Produced 133La as a Theranostic Radionuclide for 225Ac and 135La
      Bryce J.B. Nelson, Simon Ferguson, Melinda Wuest, John Wilson, M. John M. Duke, Susan Richter, Hans Soenke-Jans, Jan D. Andersson, Freimut Juengling and Frank Wuest
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 584-590; DOI: https://doi.org/10.2967/jnumed.121.262459

AI/Advanced Image Analysis

  • Basic

    • FEATURED BASIC SCIENCE ARTICLE

      • Blind Image Restoration Enhances Digital Autoradiographic Imaging of Radiopharmaceutical Tissue Distribution
        Open Access
        Blind Image Restoration Enhances Digital Autoradiographic Imaging of Radiopharmaceutical Tissue Distribution
        Lu Peng, Benabdallah Nadia, Jiang Wen, Brian W. Simons, Zhang Hanwen, Robert F. Hobbs, Ulmert David, Brian C. Baumann, Russell K. Pachynski, Abhinav K. Jha and Daniel L.J. Thorek
        Journal of Nuclear Medicine April 1, 2022, 63 (4) 591-597; DOI: https://doi.org/10.2967/jnumed.121.262270

Covid Communications

    • BRIEF COMMUNICATION

      • Experience with a Perfusion-Only Screening Protocol for Evaluation of Pulmonary Embolism During the COVID-19 Pandemic Surge
        Open Access
        Experience with a Perfusion-Only Screening Protocol for Evaluation of Pulmonary Embolism During the COVID-19 Pandemic Surge
        Arun Kumar, Renée M. Moadel, Linda B. Haramati, Kenny Ye, Leonard M. Freeman and Lionel S. Zuckier
        Journal of Nuclear Medicine April 1, 2022, 63 (4) 598-601; DOI: https://doi.org/10.2967/jnumed.121.262580

Cardiovascular

  • Clinical

    • 
    <sup>18</sup>F-FDG PET in Myocardial Viability Assessment: A Practical and Time-Efficient Protocol
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      18F-FDG PET in Myocardial Viability Assessment: A Practical and Time-Efficient Protocol
      Joyce Mhlanga, Paul Derenoncourt, Adeel Haq, Anita Bhandiwad, Richard Laforest, Barry A. Siegel, Farrokh Dehdashti, Robert J. Gropler and Thomas H. Schindler
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 602-608; DOI: https://doi.org/10.2967/jnumed.121.262432

Endocrinology

  • Clinical

    • 
    Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer <sup>11</sup>C-TASP699
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      Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699
      Mika Naganawa, Nabeel B. Nabulsi, David Matuskey, Shannan Henry, Jim Ropchan, Shu-Fei Lin, Hong Gao, Richard Pracitto, David Labaree, Ming-Rong Zhang, Tetsuya Suhara, Izumi Nishino, Helene Sabia, Satoshi Ozaki, Yiyun Huang and Richard E. Carson
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 609-614; DOI: https://doi.org/10.2967/jnumed.121.262430

Neurology

  • Clinical

    • SPECIAL CONTRIBUTION

      • A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom
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        A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom
        Ciprian Catana, Richard Laforest, Hongyu An, Fernando Boada, Tuoyu Cao, David Faul, Bjoern Jakoby, Floris P. Jansen, Bradley J. Kemp, Paul E. Kinahan, Peder Larson, Michael A. Levine, Piotr Maniawski, Osama Mawlawi, Jonathan E. McConathy, Alan B. McMillan, Julie C. Price, Abhejit Rajagopal, John Sunderland, Patrick Veit-Haibach, Kristen A. Wangerin, Chunwei Ying and Thomas A. Hope
        Journal of Nuclear Medicine April 1, 2022, 63 (4) 615-621; DOI: https://doi.org/10.2967/jnumed.120.261881

Physics and Instrumentation

  • Clinical

    • 
    Whole-Body Parametric Imaging of <sup>18</sup>F-FDG PET Using uEXPLORER with Reduced Scanning Time
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      Whole-Body Parametric Imaging of 18F-FDG PET Using uEXPLORER with Reduced Scanning Time
      Yaping Wu, Tao Feng, Yizhang Zhao, Tianyi Xu, Fangfang Fu, Zhun Huang, Nan Meng, Hongdi Li, Fengmin Shao and Meiyun Wang
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 622-628; DOI: https://doi.org/10.2967/jnumed.120.261651

Molecular Imaging

  • Basic

    • Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
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      Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
      Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A. Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J. Edwards, Nai-Kong V. Cheung and Jason S. Lewis
      Journal of Nuclear Medicine April 1, 2022, 63 (4) 629-636; DOI: https://doi.org/10.2967/jnumed.121.262383

SNMMI Newsline

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    SNMMI Newsline
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 15N-26N;
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    Medical Societies Seek Medicare Reform Collaboration
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 15N;
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    NRC Vetoes T&E Changes; Approves 82Rb and Emerging Tech Modernization
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 16N;
  • You have access
    SNMMI Calls for Expanded Coverage/Reimbursement of Amyloid PET
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 17N;
  • You have access
    ABNM: Nuclear Medicine In-Training Examination Goes Virtual
    Leonie Gordon
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 18N;
  • You have access
    SNMMI Leadership Update: SNMMI Meetings Back in Full Swing
    Virginia Pappas
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 19N;
  • You have access
    Newsbriefs
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 20N-21N;
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    From the Literature
    Journal of Nuclear Medicine April 1, 2022, 63 (4) 22N-26N;
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In this issue

Journal of Nuclear Medicine: 63 (4)
Journal of Nuclear Medicine
Vol. 63, Issue 4
April 1, 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • 177Lu-PSMA-617 and Idronoxil in Men with End-Stage Metastatic Castration-Resistant Prostate Cancer (LuPIN): Patient Outcomes and Predictors of Treatment Response in a Phase I/II Trial
  • Blind Image Restoration Enhances Digital Autoradiographic Imaging of Radiopharmaceutical Tissue Distribution
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    • Clinical
      • BRIEF COMMUNICATION
  • Theranostics
    • Clinical
      • FEATURED ARTICLE OF THE MONTH
    • Basic
  • AI/Advanced Image Analysis
    • Basic
      • FEATURED BASIC SCIENCE ARTICLE
  • Covid Communications
  • BRIEF COMMUNICATION
  • Cardiovascular
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  • Initial Clinical Experience with 90Y-FAPI-46 Radioligand Therapy for Advanced-Stage Solid Tumors: A Case Series of 9 Patients
  • Total-Body PET Multiparametric Imaging of Cancer Using a Voxelwise Strategy of Compartmental Modeling
  • Prospective phase 2 trial of PSMA-targeted molecular RadiothErapy with 177Lu-PSMA-617 for metastatic castration-reSISTant Prostate Cancer (RESIST-PC): efficacy results of the UCLA cohort
  • Why We Did What We Did: PSMA PET/CT Selection Criteria for the VISION Trial
  • 68Ga-FAPI as a Diagnostic Tool in Sarcoma: Data from the 68Ga-FAPI PET Prospective Observational Trial
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