Research ArticleBRIEF COMMUNICATION

18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy—Results from Multicenter ACRIN 6685 Clinical Trial

Rathan M. Subramaniam, Fenghai M. Duan, Justin Romanoff, Jian Qin Yu, Twyla Bartel, Farrokh Dehdashti, Charles M. Intenzo, Lilja Solnes, JoRean Sicks, Brendan C. Stack and Val J. Lowe
Journal of Nuclear Medicine December 2022, 63 (12) 1887-1890; DOI: https://doi.org/10.2967/jnumed.122.263902

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    STARD flow diagram.

  • FIGURE 2.
    FIGURE 2.

    ACRIN 6685 visual analysis: positive and negative neck nodes. (A and C) Negative 18F-FDG PET and 18F-FDG PET/CT findings for neck nodes, with visual analysis demonstrating 18F-FDG uptake in left level IIA lymph nodes equal to or less than 18F-FDG uptake in adjacent blood vessels. SUVmax was 1.1. (B and D) Positive 18F-FDG PET and 18F-FDG PET/CT findings for neck nodes, with visual analysis demonstrating 18F-FDG uptake in right level IIA lymph node greater than 18F-FDG uptake in adjacent blood vessels. SUVmax was 3.4.

Tables

  • TABLE 1.

    Diagnostic Test Statistics for Visual Assessment 18F-FDG PET/CT Scan Versus Pathology

    ReaderSensitivitySpecificityPPVNPV
    Expert H&N reader 10.791 (0.677, 0.896)0.584 (0.500, 0.665)0.417 (0.325, 0.512)0.881 (0.811, 0.942)
    Expert H&N reader 20.683 (0.547, 0.810)0.724 (0.646, 0.797)0.466 (0.352, 0.583)0.866 (0.801, 0.925)
    Central adjudicated read0.740 (0.629, 0.845)0.644 (0.567, 0.716)0.443 (0.349, 0.538)0.866 (0.800, 0.924)
    Site read0.700 (0.581, 0.817)0.699 (0.622, 0.774)0.471 (0.370, 0.580)0.859 (0.792, 0.917)

    • H&N = head and neck.

    • Data in parentheses are 95% CIs.

  • TABLE 2.

    Diagnostic Test Statistics for the Dichotomized SUVmax Result Versus Pathology

    1.8 cutoff value for SUVmax3.5 cutoff value for SUVmax
    ReaderSensitivitySpecificityPPVNPVSensitivitySpecificityPPVNPV
    Expert H&N scan reader 10.471 (0.327, 0.623)0.894 (0.862, 0.923)0.268 (0.167, 0.381)0.954 (0.931, 0.972)0.300 (0.155, 0.459)0.965 (0.942, 0.982)0.412 (0.231, 0.611)0.944 (0.919, 0.965)
    Expert H&N scan reader 20.250 (0.109, 0.419)0.900 (0.868, 0.929)0.167 (0.070, 0.281)0.938 (0.910, 0.962)0.183 (0.062, 0.330)0.967 (0.947, 0.983)0.306 (0.116, 0.517)0.937 (0.911, 0.961)
    Combined central SUVmax0.507 (0.356, 0.652)0.851 (0.814, 0.884)0.225 (0.142, 0.315)0.953 (0.930, 0.972)0.267 (0.135, 0.412)0.970 (0.952, 0.986)0.435 (0.243, 0.634)0.939 (0.915, 0.961)
    Site read0.395 (0.250, 0.548)0.903 (0.874, 0.930)0.263 (0.154, 0.383)0.945 (0.920, 0.966)0.250 (0.119, 0.395)0.972 (0.955, 0.987)0.442 (0.235, 0.658)0.937 (0.912, 0.959)

    • H&N = head and neck.

    • Data in parentheses are 95% CIs.

Additional Files

Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords