PT - JOURNAL ARTICLE AU - Subramaniam, Rathan M. AU - Duan, Fenghai M. AU - Romanoff, Justin AU - Yu, Jian Qin AU - Bartel, Twyla AU - Dehdashti, Farrokh AU - Intenzo, Charles M. AU - Solnes, Lilja AU - Sicks, JoRean AU - Stack, Brendan C. AU - Lowe, Val J. TI - <sup>18</sup>F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy—Results from Multicenter ACRIN 6685 Clinical Trial AID - 10.2967/jnumed.122.263902 DP - 2022 Dec 01 TA - Journal of Nuclear Medicine PG - 1887--1890 VI - 63 IP - 12 4099 - http://jnm.snmjournals.org/content/63/12/1887.short 4100 - http://jnm.snmjournals.org/content/63/12/1887.full SO - J Nucl Med2022 Dec 01; 63 AB - To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%–88%) for the 2 central readers and above 90% (95% CI, 90%–95%) for SUVmax for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.