RT Journal Article SR Electronic T1 18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy—Results from Multicenter ACRIN 6685 Clinical Trial JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1887 OP 1890 DO 10.2967/jnumed.122.263902 VO 63 IS 12 A1 Rathan M. Subramaniam A1 Fenghai M. Duan A1 Justin Romanoff A1 Jian Qin Yu A1 Twyla Bartel A1 Farrokh Dehdashti A1 Charles M. Intenzo A1 Lilja Solnes A1 JoRean Sicks A1 Brendan C. Stack, Jr A1 Val J. Lowe YR 2022 UL http://jnm.snmjournals.org/content/63/12/1887.abstract AB To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%–88%) for the 2 central readers and above 90% (95% CI, 90%–95%) for SUVmax for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.