Article Figures & Data
Figures
- FIGURE 1.
Correlation of surgical exploration and 18F-DOPA PET/CT findings in patient with grade 1 SiNETs and metastatic mesenteric lymph nodes of groups 2 and 3 according to Pasquer et al. (7).
- FIGURE 2.
Head-to-head comparison between 68Ga-DOTATOC (A and C) and 18F-DOPA PET/CT (B and D) in oligometastatic patient with bifocal SiNETs (*). 68Ga-DOTATOC PET/CT failed to detect hepatic and peritoneal metastases (dotted arrows), visible only on 18F-DOPA PET/CT (solid arrows). SUV-bw = (PET image pixel value) * (weight in grams) / (injected dose).
Tables
Characteristic Data Patients 53 (100%) Women 31 (58%) Age (y) 65 (13) PET/CT indication Suspicion of SiNETs 15 (28%) Staging of histologically proven metastatic SiNETs 38 (72%) World Health Organization grade, 2019 1 23 (43%) 2 25 (47%) 3 3 (6%) Ki-67 5.8 (8.7) (median, 3.7) Biochemical tumor markers Elevated serum CgA 28 (53%) Elevated 24-h urinary 5-HIAA 14 (26%) Long-acting somatostatin analogs 13 (25%) Qualitative data are number and percentage; continuous data are median and SD.
- TABLE 2.
Comparison Between 68Ga-DOTATOC and 18F-DOPA PET/CT for Primary SiNETs and Metastases (DR): Per-Lesion Analysis
Parameter 68Ga-DOTATOC 18F-DOPA Lesions Discordant patients P All primary SiNETs 106 (91%) 103 (88%) 117 14 0.549 Excised primary SiNETs 58 (76%) 53 (70%) 76* 12 0.275 Primary multifocality 6 (75%) 6 (75%) 8 (100%) 5 1.000 All metastases 694 (81%) 811 (95%) 855 38 <0.001 Subdiaphragmatic LN 165 (90%) 178 (97%) 184 14 0.009 Mesenteric LN 58 (88%) 67 (100%) 67 7 0.003 Mesenteric LN, group 1 14 (88%) 16 (100%) 16 2 0.157 Mesenteric LN, group 2 33 (92%) 36 (100%) 36 3 0.317 Mesenteric LN, group 3 11 (79%) 15 (100%) 15 3 0.046 Liver 312 (87%) 353 (99%) 357 12 <0.001 Peritoneum 53 (47%) 107 (96%) 112 12 <0.001 Lung 13 (50%) 26 (100%) 26 4 <0.001 Bone 98 (84%) 100 (86%) 116 7 0.732 Supradiaphragmatic LN 30 (81%) 28 (76%) 37 10 0.617 Left supraclavicular LN 23 (100%) 19 (83%) 23 3 0.046 ↵* 76 primary SiNETs detected at histology (sensitivity) in 37 surgically treated patients.
LN = lymph nodes.
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