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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigation

A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177Lu-Peptide Receptor Radionuclide Therapy

Yuni K. Dewaraja, David M. Mirando, Avery B. Peterson, Jeremy Niedbala, John D. Millet, Justin K. Mikell, Kirk A. Frey, Ka Kit Wong, Scott J. Wilderman and Aaron S. Nelson
Journal of Nuclear Medicine November 2022, 63 (11) 1665-1672; DOI: https://doi.org/10.2967/jnumed.121.263738
Yuni K. Dewaraja
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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David M. Mirando
2MIM Software Inc., Cleveland, Ohio;
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Avery B. Peterson
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
3Department of Radiation Oncology, Wayne State University, Detroit, Michigan; and
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Jeremy Niedbala
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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John D. Millet
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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Justin K. Mikell
4Radiation Oncology, University of Michigan, Ann Arbor, Michigan
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Kirk A. Frey
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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Ka Kit Wong
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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Scott J. Wilderman
1Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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Aaron S. Nelson
2MIM Software Inc., Cleveland, Ohio;
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Journal of Nuclear Medicine: 63 (11)
Journal of Nuclear Medicine
Vol. 63, Issue 11
November 1, 2022
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A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177Lu-Peptide Receptor Radionuclide Therapy
Yuni K. Dewaraja, David M. Mirando, Avery B. Peterson, Jeremy Niedbala, John D. Millet, Justin K. Mikell, Kirk A. Frey, Ka Kit Wong, Scott J. Wilderman, Aaron S. Nelson
Journal of Nuclear Medicine Nov 2022, 63 (11) 1665-1672; DOI: 10.2967/jnumed.121.263738

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A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177Lu-Peptide Receptor Radionuclide Therapy
Yuni K. Dewaraja, David M. Mirando, Avery B. Peterson, Jeremy Niedbala, John D. Millet, Justin K. Mikell, Kirk A. Frey, Ka Kit Wong, Scott J. Wilderman, Aaron S. Nelson
Journal of Nuclear Medicine Nov 2022, 63 (11) 1665-1672; DOI: 10.2967/jnumed.121.263738
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Cited By...

  • Multicycle Dosimetric Behavior and Dose-Effect Relationships in [177Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy
  • An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 3: Contribution from Calculating Absorbed Dose from Time-Integrated Activity
  • SPECT/CT Image-Derived Absorbed Dose to Red Marrow Correlates with Hematologic Toxicity in Patients Treated with [177Lu]Lu-DOTATATE
  • Lesion Dosimetry for [177Lu]Lu-PSMA-617 Radiopharmaceutical Therapy Combined with Stereotactic Body Radiotherapy in Patients with Oligometastatic Castration-Sensitive Prostate Cancer
  • Single-Time-Point Imaging for Dosimetry After [177Lu]Lu-DOTATATE: Accuracy of Existing Methods and Novel Data-Driven Models for Reducing Sensitivity to Time-Point Selection
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  • Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
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Keywords

  • radionuclide therapy
  • theranostics
  • SPECT/CT
  • 177Lu
  • dosimetry
  • Monte Carlo
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