Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleFocus on Molecular Imaging

Advances and Future Directions in Molecular Breast Imaging

Matthew F. Covington, Ephraim E. Parent, Elizabeth H. Dibble, Gaiane M. Rauch and Amy M. Fowler
Journal of Nuclear Medicine January 2022, 63 (1) 17-21; DOI: https://doi.org/10.2967/jnumed.121.261988
Matthew F. Covington
1Center for Quantitative Cancer Imaging, Huntsman Cancer Institute and University of Utah Department of Radiology and Imaging Sciences, Salt Lake City, Utah;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ephraim E. Parent
2Mayo Clinic Department of Radiology, Jacksonville, Florida;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth H. Dibble
3Warren Alpert Medical School of Brown University/Rhode Island Hospital Department of Diagnostic Imaging, Providence, Rhode Island;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gaiane M. Rauch
4M.D. Anderson Cancer Center, Departments of Abdominal and Breast Imaging, Houston, Texas; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy M. Fowler
5University of Wisconsin School of Medicine and Public Health, Departments of Radiology and Medical Physics and the University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    MBI with 300 MBq (8 mCi) of 99mTc-sestamibi for extent-of-disease evaluation in 59-y-old woman with palpable irregular mass (arrows) in right upper central breast. (A and B) Mass measured 3.3 cm on craniocaudal (A) and mediolateral oblique (B) mammograms. (C and D) MBI showed 10 cm of uptake on craniocaudal (C) and mediolateral oblique (D) views. (E and F) Postcontrast axial (E) and sagittal (F) MRI confirmed 10.2 cm of abnormal enhancement. After NAT and mastectomy, surgical pathology showed 8-cm treated tumor bed with 0.2 cm of residual invasive carcinoma.

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    A 38-y-old woman with right-breast triple-negative and node-negative invasive ductal carcinoma (arrows). (A and B) Pretreatment postcontrast sagittal fat-suppressed T1-weighted MRI shows irregular mass in right breast (A), and MBI with 300 MBq (8 mCi) of 99mTc-sestamibi shows intense uptake in mediolateral oblique view (B). (C and D) On posttreatment imaging, there is no residual enhancement on MRI (C) and no residual uptake on MBI (D). Surgical pathology showed pathologic complete response.

  • FIGURE 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3.

    Different degrees of BPU on MBI (300 MBq [8 mCi] of 99mTc-sestamibi): photopenic (fibroglandular uptake less intense than fat uptake) (A), minimal to mild (fibroglandular uptake equal to, or just noticeably more intense than, fat uptake) (B), moderate (fibroglandular uptake more than mild but less than twice as intense as fat uptake) (C), and marked (fibroglandular uptake at least twice as intense as fat uptake) (D).

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 63 (1)
Journal of Nuclear Medicine
Vol. 63, Issue 1
January 1, 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Advances and Future Directions in Molecular Breast Imaging
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Advances and Future Directions in Molecular Breast Imaging
Matthew F. Covington, Ephraim E. Parent, Elizabeth H. Dibble, Gaiane M. Rauch, Amy M. Fowler
Journal of Nuclear Medicine Jan 2022, 63 (1) 17-21; DOI: 10.2967/jnumed.121.261988

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Advances and Future Directions in Molecular Breast Imaging
Matthew F. Covington, Ephraim E. Parent, Elizabeth H. Dibble, Gaiane M. Rauch, Amy M. Fowler
Journal of Nuclear Medicine Jan 2022, 63 (1) 17-21; DOI: 10.2967/jnumed.121.261988
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • CURRENT STATE OF THE ART
    • RADIATION EXPOSURE
    • INDICATIONS AND CLINICAL APPLICATIONS
    • PRESENT AND FUTURE DEVELOPMENTS
    • CONCLUSION
    • DISCLOSURE
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • From Genome to Phenome: Opportunities and Challenges of Molecular Imaging
  • Imaging the Activity of Efflux Transporters at the Blood–Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria
  • Molecular Imaging of Pulmonary Fibrosis
Show more Focus on Molecular Imaging

Similar Articles

Keywords

  • molecular breast imaging
  • MBI
  • breast specific γ-imaging
  • nuclear breast imaging
  • sestamibi
SNMMI

© 2025 SNMMI

Powered by HighWire