%0 Journal Article %A Matthew F. Covington %A Ephraim E. Parent %A Elizabeth H. Dibble %A Gaiane M. Rauch %A Amy M. Fowler %T Advances and Future Directions in Molecular Breast Imaging %D 2022 %R 10.2967/jnumed.121.261988 %J Journal of Nuclear Medicine %P 17-21 %V 63 %N 1 %X Molecular breast imaging (MBI) using 99mTc-sestamibi has advanced rapidly over the past decade. Technical advances allow lower-dose, higher-resolution imaging and biopsy capability. MBI can be used for supplemental breast cancer screening with mammography for women with dense breasts, as well as to assess neoadjuvant therapy response, evaluate disease extent, and predict breast cancer risk. This article highlights the current state of the art and future directions in MBI. %U https://jnm.snmjournals.org/content/jnumed/63/1/17.full.pdf