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Journal of Nuclear Medicine

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Table of Contents

January 1, 2022; Volume 63,Issue 1

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 10A;

Discussions with Leaders

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    Advancing Nuclear Medicine in Australia over 3 Decades
    Rodney Hicks, Johannes Czernin and Ken Herrmann
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 1-4; DOI: https://doi.org/10.2967/jnumed.121.263338

The State of The Art

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    Harnessing α-Emitting Radionuclides for Therapy: Radiolabeling Method Review
    Hua Yang, Justin J. Wilson, Chris Orvig, Yawen Li, D. Scott Wilbur, Caterina F. Ramogida, Valery Radchenko and Paul Schaffer
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 5-13; DOI: https://doi.org/10.2967/jnumed.121.262687

Hot Topics

  • Imaging the Inflammatory Response in Checkpoint Inhibition Myocarditis
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    Imaging the Inflammatory Response in Checkpoint Inhibition Myocarditis
    Christoph Rischpler, Tienush Rassaf, Lale Umutlu, Ken Herrmann, Thomas-Wilfried Schlosser and Matthias Totzeck
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 14-16; DOI: https://doi.org/10.2967/jnumed.121.262301

Focus on Molecular Imaging

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    Advances and Future Directions in Molecular Breast Imaging
    Matthew F. Covington, Ephraim E. Parent, Elizabeth H. Dibble, Gaiane M. Rauch and Amy M. Fowler
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 17-21; DOI: https://doi.org/10.2967/jnumed.121.261988

Oncology

  • Clinical

    • Imaging Androgen Receptors in Breast Cancer with <sup>18</sup>F-Fluoro-5α-Dihydrotestosterone PET: A Pilot Study
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      Imaging Androgen Receptors in Breast Cancer with 18F-Fluoro-5α-Dihydrotestosterone PET: A Pilot Study
      Heather Jacene, Mofei Liu, Su-Chun Cheng, Amanda Abbott, Shipra Dubey, Keisha McCall, Diane Young, Mayzie Johnston, Annick D. Van den Abbeele and Beth Overmoyer
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 22-28; DOI: https://doi.org/10.2967/jnumed.121.262068
    • Cerenkov Luminescence Imaging in Prostate Cancer: Not the Only Light That Shines
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      Cerenkov Luminescence Imaging in Prostate Cancer: Not the Only Light That Shines
      Judith olde Heuvel, Berlinda J. de Wit-van der Veen, Henk G. van der Poel, Pim J. van Leeuwen, Elise M. Bekers, Maarten R. Grootendorst, Kunal N. Vyas, Cornelis H. Slump and Marcel P.M. Stokkel
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 29-35; DOI: https://doi.org/10.2967/jnumed.120.260034
    • First-in-Human PET Imaging and Estimated Radiation Dosimetry of <span class="sc">l</span>-[5-<sup>11</sup>C]-Glutamine in Patients with Metastatic Colorectal Cancer
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      First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer
      Allison S. Cohen, Joe Grudzinski, Gary T. Smith, Todd E. Peterson, Jennifer G. Whisenant, Tiffany L. Hickman, Kristen K. Ciombor, Dana Cardin, Cathy Eng, Laura W. Goff, Satya Das, Robert J. Coffey, Jordan D. Berlin and H. Charles Manning
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 36-43; DOI: https://doi.org/10.2967/jnumed.120.261594
    • Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1–Targeted <sup>18</sup>F-Fluorthanatrace PET Images of Ovarian Cancer
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      Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1–Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer
      Anthony J. Young, Austin R. Pantel, Varsha Viswanath, Tiffany L. Dominguez, Mehran Makvandi, Hsiaoju Lee, Shihong Li, Erin K. Schubert, Daniel A. Pryma, Michael D. Farwell, Robert H. Mach, Fiona Simpkins, Lilie L. Lin, David A. Mankoff and Robert K. Doot
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 44-50; DOI: https://doi.org/10.2967/jnumed.121.261894
    • c-MET Receptor–Targeted Fluorescence on the Road to Image-Guided Surgery in Penile Squamous Cell Carcinoma Patients
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      c-MET Receptor–Targeted Fluorescence on the Road to Image-Guided Surgery in Penile Squamous Cell Carcinoma Patients
      Hielke M. de Vries, Elise Bekers, Matthias N. van Oosterom, M. Baris Karakullukcu, Henk G. van, der Poel, Fijs W.B. van Leeuwen, Tessa Buckle and Oscar R. Brouwer
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 51-56; DOI: https://doi.org/10.2967/jnumed.120.261864
    • INVITED PERSPECTIVE

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        Transarterial Radioembolization Versus Systemic Treatment for Hepatocellular Carcinoma with Macrovascular Invasion: Analysis of the U.S. National Cancer Database
        Riad Salem and Ahmed Gabr
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 57-58; DOI: https://doi.org/10.2967/jnumed.121.262917

Theranostics

  • Clinical

    • APPROPRIATE USE CRITERIA

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        Appropriate Use Criteria for Prostate-Specific Membrane Antigen PET Imaging
        Hossein Jadvar, Jeremie Calais, Stefano Fanti, Felix Feng, Kirsten L. Greene, James L. Gulley, Michael Hofman, Bridget F. Koontz, Daniel W. Lin, Michael J. Morris, Steve P. Rowe, Trevor J. Royce, Simpa Salami, Bital Savir-Baruch, Sandy Srinivas and Thomas A. Hope
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 59-68; DOI: https://doi.org/10.2967/jnumed.121.263262
    • The Added Value of <sup>18</sup>F-FDG PET/CT Compared with <sup>68</sup>Ga-PSMA PET/CT in Patients with Castration-Resistant Prostate Cancer
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      The Added Value of 18F-FDG PET/CT Compared with 68Ga-PSMA PET/CT in Patients with Castration-Resistant Prostate Cancer
      Ruohua Chen, Yining Wang, Yinjie Zhu, Yiping Shi, Lian Xu, Gang Huang and Jianjun Liu
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 69-75; DOI: https://doi.org/10.2967/jnumed.120.262250
    • BRIEF COMMUNICATION

      • PSMA PET Validates Higher Rates of Metastatic Disease for European Association of Urology Biochemical Recurrence Risk Groups: An International Multicenter Study
        Open Access
        PSMA PET Validates Higher Rates of Metastatic Disease for European Association of Urology Biochemical Recurrence Risk Groups: An International Multicenter Study
        Justin Ferdinandus, Wolfgang P. Fendler, Andrea Farolfi, Samuel Washington, Osama Mohamad, Miguel H. Pampaloni, Peter J.H. Scott, Melissa Rodnick, Benjamin L. Viglianti, Matthias Eiber, Ken Herrmann, Johannes Czernin, Wesley R. Armstrong, Jeremie Calais, Thomas A. Hope and Morand Piert
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 76-80; DOI: https://doi.org/10.2967/jnumed.121.262821
    • <sup>68</sup>Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with <sup>18</sup>F-FDG PET/CT
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      68Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with 18F-FDG PET/CT
      Chunxia Qin, Fuqiang Shao, Yongkang Gai, Qingyao Liu, Weiwei Ruan, Fang Liu, Fan Hu and Xiaoli Lan
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 81-88; DOI: https://doi.org/10.2967/jnumed.120.258467
    • <sup>68</sup>Ga-FAPI as a Diagnostic Tool in Sarcoma: Data from the <sup>68</sup>Ga-FAPI PET Prospective Observational Trial
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      68Ga-FAPI as a Diagnostic Tool in Sarcoma: Data from the 68Ga-FAPI PET Prospective Observational Trial
      Lukas Kessler, Justin Ferdinandus, Nader Hirmas, Sebastian Bauer, Uta Dirksen, Fadi Zarrad, Michael Nader, Michal Chodyla, Aleksandar Milosevic, Lale Umutlu, Martin Schuler, Lars Erik Podleska, Hans-Ulrich Schildhaus, Wolfgang P. Fendler and Rainer Hamacher
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 89-95; DOI: https://doi.org/10.2967/jnumed.121.262096
    • BRIEF COMMUNICATION

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        68Ga-Pentixafor PET/CT for Detection of Chemokine Receptor CXCR4 Expression in Myeloproliferative Neoplasms
        Sabrina Kraus, Alexander Dierks, Leo Rasche, Olivia Kertels, Malte Kircher, Andreas Schirbel, Josip Zovko, Torsten Steinbrunn, Raoul Tibes, Hans-Jürgen Wester, Andreas K. Buck, Hermann Einsele, K. Martin Kortüm, Andreas Rosenwald and Constantin Lapa
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 96-99; DOI: https://doi.org/10.2967/jnumed.121.262206
  • Basic

    • Dosimetric Evaluation of the Effect of Receptor Heterogeneity on the Therapeutic Efficacy of Peptide Receptor Radionuclide Therapy: Correlation with DNA Damage Induction and In Vivo Survival
      Open Access
      Dosimetric Evaluation of the Effect of Receptor Heterogeneity on the Therapeutic Efficacy of Peptide Receptor Radionuclide Therapy: Correlation with DNA Damage Induction and In Vivo Survival
      Giulia Tamborino, Julie Nonnekens, Marijke De Saint-Hubert, Lara Struelens, Danny Feijtel, Marion de Jong and Mark W. Konijnenberg
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 100-107; DOI: https://doi.org/10.2967/jnumed.121.262122

Neurology

  • Clinical

    • Direct Comparison of the Tau PET Tracers <sup>18</sup>F-Flortaucipir and <sup>18</sup>F-MK-6240 in Human Subjects
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      Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects
      Alexandra Gogola, Davneet S. Minhas, Victor L. Villemagne, Ann D. Cohen, James M. Mountz, Tharick A. Pascoal, Charles M. Laymon, N. Scott Mason, Milos D. Ikonomovic, Chester A. Mathis, Beth E. Snitz, Oscar L. Lopez, William E. Klunk and Brian J. Lopresti
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 108-116; DOI: https://doi.org/10.2967/jnumed.120.254961
  • Basic

    • Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
      Open Access
      Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
      Gloria Biechele, Laura Sebastian Monasor, Karin Wind, Tanja Blume, Samira Parhizkar, Thomas Arzberger, Christian Sacher, Leonie Beyer, Florian Eckenweber, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Michael Willem, Peter Bartenstein, Paul Cumming, Axel Rominger, Jochen Herms, Stefan F. Lichtenthaler, Christian Haass, Sabina Tahirovic and Matthias Brendel
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 117-124; DOI: https://doi.org/10.2967/jnumed.120.261858

Pulmonary

  • Clinical

    • INVITED PERSPECTIVE

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        Perspective on Fibroblast Activation Protein–Specific PET/CT in Fibrotic Interstitial Lung Diseases: Imaging Fibrosis—A New Paradigm for Molecular Imaging?
        Christian Schmidkonz
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 125-126; DOI: https://doi.org/10.2967/jnumed.121.262944
    • FEATURED ARTICLE OF THE MONTH

      • Fibroblast Activation Protein–Specific PET/CT Imaging in Fibrotic Interstitial Lung Diseases and Lung Cancer: A Translational Exploratory Study
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        Fibroblast Activation Protein–Specific PET/CT Imaging in Fibrotic Interstitial Lung Diseases and Lung Cancer: A Translational Exploratory Study
        Manuel Röhrich, Dominik Leitz, Frederik M. Glatting, Annika K. Wefers, Oliver Weinheimer, Paul Flechsig, Nicolas Kahn, Marcus A. Mall, Frederik L. Giesel, Clemens Kratochwil, Peter E. Huber, Andreas von Deimling, Claus Peter Heußel, Hans Ulrich Kauczor, Michael Kreuter and Uwe Haberkorn
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 127-133; DOI: https://doi.org/10.2967/jnumed.121.261925

Infectious Disease

  • Clinical

    • COVID-19 mRNA Vaccination: Age and Immune Status and Its Association with Axillary Lymph Node PET/CT Uptake
      Open Access
      COVID-19 mRNA Vaccination: Age and Immune Status and Its Association with Axillary Lymph Node PET/CT Uptake
      Michal Eifer, Noam Tau, Yousef Alhoubani, Nayroz Kanana, Liran Domachevsky, Jala Shams, Nir Keret, Malka Gorfine and Yael Eshet
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 134-139; DOI: https://doi.org/10.2967/jnumed.121.262194
  • Basic

    • FEATURED BASIC SCIENCE ARTICLE

      • Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using <sup>18</sup>F-FAraG PET and MRI
        Open Access
        Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI
        Caroline Guglielmetti, Jelena Levi, Tony L. Huynh, Brice Tiret, Joseph Blecha, Ryan Tang, Henry VanBrocklin and Myriam M. Chaumeil
        Journal of Nuclear Medicine January 1, 2022, 63 (1) 140-146; DOI: https://doi.org/10.2967/jnumed.120.259325

AI/Advanced Image Analysis

  • Clinical

    • <sup>18</sup>F-FDOPA PET for the Noninvasive Prediction of Glioma Molecular Parameters: A Radiomics Study
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      18F-FDOPA PET for the Noninvasive Prediction of Glioma Molecular Parameters: A Radiomics Study
      Timothée Zaragori, Julien Oster, Véronique Roch, Gabriela Hossu, Mohammad B. Chawki, Rachel Grignon, Celso Pouget, Guillaume Gauchotte, Fabien Rech, Marie Blonski, Luc Taillandier, Laëtitia Imbert and Antoine Verger
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 147-157; DOI: https://doi.org/10.2967/jnumed.120.261545
    • You have access
      Machine Learning with 18F-Sodium Fluoride PET and Quantitative Plaque Analysis on CT Angiography for the Future Risk of Myocardial Infarction
      Jacek Kwiecinski, Evangelos Tzolos, Mohammed N. Meah, Sebastien Cadet, Philip D. Adamson, Kajetan Grodecki, Nikhil V. Joshi, Alastair J. Moss, Michelle C. Williams, Edwin J.R. van Beek, Daniel S. Berman, David E. Newby, Damini Dey, Marc R. Dweck and Piotr J. Slomka
      Journal of Nuclear Medicine January 1, 2022, 63 (1) 158-165; DOI: https://doi.org/10.2967/jnumed.121.262283

Letters To The Editor

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    Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients After SARS-CoV2 Infection and Comparison to Fibrotic Lungs
    Pauline T. Lukey and Frederick J. Wilson
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 166; DOI: https://doi.org/10.2967/jnumed.121.262342
  • You have access
    Potential Theranostic Role of Bone Marrow Glucose Metabolism on Baseline 18F-FDG PET/CT in Metastatic Melanoma
    Romain-David Seban, Laurence Champion, Izza Muneer, Shwe Synn, Lawrence H. Schwartz and Laurent Dercle
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 166; DOI: https://doi.org/10.2967/jnumed.121.262361
  • You have access
    Is 18F-FDG PET/CT Effective in Identifying True Residual Disease After Treatment of Pediatric PTLD?
    Batool El-Atoum, Mark Ebert, Brian Bucher and Zeinab Afify
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 167-168; DOI: https://doi.org/10.2967/jnumed.121.262414

SNMMI Newsline

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    SNMMI Newsline
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 11N-22N;
  • You have access
    2021 SNMMI Highlights Lecture: Cardiovascular Track
    Sharmila Dorbala
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 11N-16N;
  • You have access
    SNMMI Adopts Family Leave Statement
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 17N;
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    Ensuring Quality and Safety in Nuclear Medicine Imaging and Therapy
    Richard L. Wahl
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 18N;
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    Regarding LNT: Scientifically Worthless and Increasingly Indefensible; Regarding LNT: NRC Wrongfully Rejects Petitions to End LNT Model Use
    Carol S. Marcus and Jerry M. Cuttler
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 19N-20N;
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    Newsbriefs
    Journal of Nuclear Medicine January 1, 2022, 63 (1) 21N-22N;
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In this issue

Journal of Nuclear Medicine: 63 (1)
Journal of Nuclear Medicine
Vol. 63, Issue 1
January 1, 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • Fibroblast Activation Protein–Specific PET/CT Imaging in Fibrotic Interstitial Lung Diseases and Lung Cancer: A Translational Exploratory Study
  • Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI
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  • Theranostics
    • Clinical
      • APPROPRIATE USE CRITERIA
      • BRIEF COMMUNICATION
      • BRIEF COMMUNICATION
    • Basic
  • Neurology
    • Clinical
    • Basic
  • Pulmonary
    • Clinical
      • INVITED PERSPECTIVE
      • FEATURED ARTICLE OF THE MONTH
  • Infectious Disease
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  • First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  • Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View
  • Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients
  • Tumor Response to Radiopharmaceutical Therapies: The Knowns and the Unknowns
  • Is FDG maximum standardized uptake value (SUV max) of primary breast cancer can predict axillary lymph node metastasis?
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