Article Figures & Data
Figures
- FIGURE 1.
Whole-body coronal PET images of healthy volunteer (male; age, 29 y; weight, 74 kg; height, 183 cm) after intravenous injection of 167 MBq of 68Ga-DOTA-Siglec-9. Distribution of 68Ga-radioactivity 1–4 min after injection, based on imaging for 30 s per bed position, revealed high uptake, predominantly in heart, liver, kidneys, and ureter. At 20–36 min after injection and subsequent times, uptake was mainly in kidneys, ureter, and urinary bladder.
- FIGURE 2.
Decay-corrected time–activity curves of main organs. Result for urinary bladder in subject 6 was outlier so is presented separately. LV = left ventricle.
- FIGURE 3.
68Ga-DOTA-Siglec-9 and 18F-FDG PET/CT and MR images of hands of 49-y-old patient with early RA. Arrows denote proximal interphalangeal joints PIP2 and PIP3 and distal interphalangeal joint DIP3, whose time–activity curves are at bottom left. Respective SUVs were 1.05, 0.92, and 0.70 with 68Ga-DOTA-Siglec-9 and 1.46, 1.22. and 1.08 with 18F-FDG.
- FIGURE 4.
Representative radio-HPLC chromatograms of intact 68Ga-DOTA-Siglec-9 (A), human plasma 5 min after injection (B), and urine at 40 min after injection (C). In addition to parent tracer, several other peaks were detected in plasma, whereas in urine, radioactivity was entirely from radiometabolite.
- FIGURE 5.
(A and B) Total radioactivity (A) and proportion of parent tracer (B) decreased rapidly in blood circulation. (C) On average, 26% of radioactivity was bound to plasma proteins.
Tables
- TABLE 1
Normalized Number of Disintegrations (Hours) in Source Organs After Injection of 68Ga-DOTA-Siglec-9
Site Mean SD Minimum Maximum Bone, cortical 0.0260 0.0045 0.0195 0.0312 Bone, trabecular 0.0039 0.0017 0.0025 0.0064 Brain 0.0047 0.0013 0.0033 0.0069 Heart contents 0.0033 0.0003 0.0030 0.0036 Kidneys 0.0359 0.0104 0.0231 0.0485 Liver 0.0377 0.0055 0.0266 0.0409 Lungs 0.0133 0.0033 0.0105 0.0176 Pancreas 0.0017 0.0004 0.0012 0.0021 Red marrow 0.0099 0.0019 0.0069 0.0127 Salivary gland 0.0005 0.0001 0.0005 0.0006 Spleen 0.0033 0.0004 0.0029 0.0040 Urinary bladder 0.3252 0.0426 0.2662 0.3831 Remainder of body 0.7257 0.0906 0.5861 0.8501 - TABLE 2
Dose-Equivalent Estimates (μSv/MBq) and Effective Dose (mSv/MBq) After Injection of 68Ga-DOTA-Siglec-9
Site Mean SD Minimum Maximum Adrenals 12.2 1.4 10.7 14.2 Brain 2.4 0.5 1.9 3.3 Colon, left 8.3 0.8 7.2 9.3 Colon, right 8.4 0.8 7.3 9.4 Esophagus 6.9 0.8 5.9 8.0 Eyes 5.9 0.7 4.8 6.9 Gallbladder wall 8.7 0.9 7.7 9.8 Heart wall 11.5 1.3 10.0 13.3 Kidneys 54.4 14.9 36.0 72.5 Liver 12.7 1.6 9.4 13.7 Lungs 6.8 1.2 5.8 8.5 Osteogenic cells 9.9 1.2 8.4 11.7 Pancreas 8.5 1.4 6.8 10.0 Prostate 17.4 0.5 16.7 17.9 Rectum 14.1 0.1 14.0 14.3 Red marrow 8.6 0.8 7.7 10.0 Salivary glands 4.5 0.3 4.0 5.0 Small intestine 9.5 0.6 8.5 10.3 Spleen 12.8 1.2 11.5 14.6 Stomach wall 7.5 0.8 6.4 8.7 Testes 8.8 0.5 8.0 9.5 Thymus 6.8 0.8 5.7 8.0 Thyroid 6.7 0.8 5.5 7.8 Urinary bladder wall 383.2 48.5 316.0 449.0 Whole body 10.1 0.5 9.4 10.7 Effective dose* 0.022 0.002 0.020 0.024 ↵* International Commission on Radiological Protection publication 103 (16).
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