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Journal of Nuclear Medicine

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Table of Contents

April 1, 2021; Volume 62,Issue 4

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 8A;

Discussions with Leaders

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    Leadership in Medicine, Industry, and Innovation: A Conversation Between Jörg F. Debatin and Thomas Beyer
    Jörg F. Debatin and Thomas Beyer
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 435-437; DOI: https://doi.org/10.2967/jnumed.121.262107

The State of the Art

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    The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
    Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman and Danielle J. Vugts
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 438-445; DOI: https://doi.org/10.2967/jnumed.119.239558

Continuing Education

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    Bone Mineral Density: Clinical Relevance and Quantitative Assessment
    Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian and Azeez Farooki
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 446-454; DOI: https://doi.org/10.2967/jnumed.120.256180

Hot Topics

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    Agent Optimization: Absorption, Distribution, Metabolism, Excretion, Dose, and Decay
    Martin W. Brechbiel
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 455-456; DOI: https://doi.org/10.2967/jnumed.120.258095

Focus on Molecular Imaging

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    Advances in Imaging Reactive Oxygen Species
    Eli M. Espinoza, Joachim Justad Røise, I-Che Li, Riddha Das and Niren Murthy
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 457-461; DOI: https://doi.org/10.2967/jnumed.120.245415

Editorial

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    The Evolution of PET/MR Is Hindered by Our Field’s Reluctance to Provide Critical Evaluation
    Adam L. Kesner
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 462-463; DOI: https://doi.org/10.2967/jnumed.120.260950

Oncology

  • Clinical

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      Treatment Monitoring of Immunotherapy and Targeted Therapy Using 18F-FET PET in Patients with Melanoma and Lung Cancer Brain Metastases: Initial Experiences
      Norbert Galldiks, Diana S.Y. Abdulla, Matthias Scheffler, Fabian Wolpert, Jan-Michael Werner, Martin Hüllner, Gabriele Stoffels, Viola Schweinsberg, Max Schlaak, Nicole Kreuzberg, Jennifer Landsberg, Philipp Lohmann, Garry Ceccon, Christian Baues, Maike Trommer, Eren Celik, Maximilian I. Ruge, Martin Kocher, Simone Marnitz, Gereon R. Fink, Jörg-Christian Tonn, Michael Weller, Karl-Josef Langen, Jürgen Wolf and Cornelia Mauch
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 464-470; DOI: https://doi.org/10.2967/jnumed.120.248278
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      Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial
      Nils H. Nicolay, Alexander Rühle, Nicole Wiedenmann, Gabriele Niedermann, Michael Mix, Wolfgang A. Weber, Dimos Baltas, Martin Werner, Gian Kayser and Anca-L. Grosu
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 471-478; DOI: https://doi.org/10.2967/jnumed.120.248633
    • Surveillance of Clinically Complete Responders Using Serial <sup>18</sup>F-FDG PET/CT Scans in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy
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      Surveillance of Clinically Complete Responders Using Serial 18F-FDG PET/CT Scans in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy
      Maria J. Valkema, Berend J. van der Wilk, Ben M. Eyck, Bas P.L. Wijnhoven, Manon C.W. Spaander, Michail Doukas, Sjoerd M. Lagarde, Wendy M.J. Schreurs, Mark J. Roef, J. Jan B. van Lanschot and Roelf Valkema
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 486-492; DOI: https://doi.org/10.2967/jnumed.120.247981
    • Phase I Study of <sup>99m</sup>Tc-ADAPT6, a Scaffold Protein–Based Probe for Visualization of HER2 Expression in Breast Cancer
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      Phase I Study of 99mTc-ADAPT6, a Scaffold Protein–Based Probe for Visualization of HER2 Expression in Breast Cancer
      Olga Bragina, Emma von Witting, Javad Garousi, Roman Zelchan, Mattias Sandström, Anna Orlova, Anna Medvedeva, Artem Doroshenko, Anzhelika Vorobyeva, Sarah Lindbo, Jesper Borin, Natalya Tarabanovskaya, Jens Sörensen, Sophia Hober, Vladimir Chernov and Vladimir Tolmachev
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 493-499; DOI: https://doi.org/10.2967/jnumed.120.248799
  • Translational

    • First Experience Using <sup>18</sup>F-Flubrobenguane PET Imaging in Patients with Suspected Pheochromocytoma or Paraganglioma
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      First Experience Using 18F-Flubrobenguane PET Imaging in Patients with Suspected Pheochromocytoma or Paraganglioma
      Lukas Kessler, Anna M. Schlitter, Markus Krönke, Alexander von Werder, Robert Tauber, Tobias Maurer, Simon Robinson, Cesare Orlandi, Michael Herz, Behrooz H. Yousefi, Stephan G. Nekolla, Markus Schwaiger, Matthias Eiber and Christoph Rischpler
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 479-485; DOI: https://doi.org/10.2967/jnumed.120.248021
  • Basic

    • Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating <em>ESR1</em> Mutation
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      Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation
      Manoj Kumar, Kelley Salem, Justin J. Jeffery, Yongjun Yan, Aparna M. Mahajan and Amy M. Fowler
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 500-506; DOI: https://doi.org/10.2967/jnumed.120.249508

Theranostics

  • Clinical

    • FEATURED CLINICAL INVESTIGATION ARTICLE

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        Somatostatin Receptor–Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis
        Christian Mirian, Anne Katrine Duun-Henriksen, Andrea Maier, Maria Møller Pedersen, Lasse Rehné Jensen, Asma Bashir, Thomas Graillon, Maya Hrachova, Daniela Bota, Martjin van Essen, Petar Spanjol, Christian Kreis, Ian Law, Helle Broholm, Lars Poulsgaard, Kåre Fugleholm, Morten Ziebell, Tina Munch, Martin A. Walter and Tiit Mathiesen
        Journal of Nuclear Medicine April 1, 2021, 62 (4) 507-513; DOI: https://doi.org/10.2967/jnumed.120.249607
    • High Interobserver Agreement for the Standardized Reporting System SSTR-RADS 1.0 on Somatostatin Receptor PET/CT
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      High Interobserver Agreement for the Standardized Reporting System SSTR-RADS 1.0 on Somatostatin Receptor PET/CT
      Rudolf A. Werner, Thorsten Derlin, Steven P. Rowe, Lena Bundschuh, Gabriel T. Sheikh, Martin G. Pomper, Sebastian Schulz, Takahiro Higuchi, Andreas K. Buck, Frank M. Bengel, Ralph A. Bundschuh and Constantin Lapa
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 514-520; DOI: https://doi.org/10.2967/jnumed.120.245464
  • Basic

    • <sup>177</sup>Lu-Labeled Albumin-Binder–Conjugated PSMA-Targeting Agents with Extremely High Tumor Uptake and Enhanced Tumor-to-Kidney Absorbed Dose Ratio
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      177Lu-Labeled Albumin-Binder–Conjugated PSMA-Targeting Agents with Extremely High Tumor Uptake and Enhanced Tumor-to-Kidney Absorbed Dose Ratio
      Hsiou-Ting Kuo, Kuo-Shyan Lin, Zhengxing Zhang, Carlos F. Uribe, Helen Merkens, Chengcheng Zhang and François Bénard
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 521-527; DOI: https://doi.org/10.2967/jnumed.120.250738

AI/Advanced Image Analysis

  • Clinical

    • Deep-Learning Generation of Synthetic Intermediate Projections Improves <sup>177</sup>Lu SPECT Images Reconstructed with Sparsely Acquired Projections
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      Deep-Learning Generation of Synthetic Intermediate Projections Improves 177Lu SPECT Images Reconstructed with Sparsely Acquired Projections
      Tobias Rydén, Martijn Van Essen, Ida Marin, Johanna Svensson and Peter Bernhardt
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 528-535; DOI: https://doi.org/10.2967/jnumed.120.245548

Cardiovascular

  • Basic

    • FEATURED BASIC SCIENCE ARTICLE

      • Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with <sup>18</sup>F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
        Open Access
        Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
        Mark G. MacAskill, Agne Stadulyte, Lewis Williams, Timaeus E.F. Morgan, Nikki L. Sloan, Carlos J. Alcaide-Corral, Tashfeen Walton, Catriona Wimberley, Chris-Anne McKenzie, Nick Spath, William Mungall, Ralph BouHaidar, Marc R. Dweck, Gillian A. Gray, David E. Newby, Christophe Lucatelli, Andrew Sutherland, Sally L. Pimlott and Adriana A.S. Tavares
        Journal of Nuclear Medicine April 1, 2021, 62 (4) 536-544; DOI: https://doi.org/10.2967/jnumed.120.243600

Neurology

  • Clinical

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      Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography
      Carlos A. Sanchez-Catasus, Nicolaas I. Bohnen, Fang-Cheng Yeh, Nicholas D’Cruz, Prabesh Kanel and Martijn L.T.M. Müller
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 545-552; DOI: https://doi.org/10.2967/jnumed.120.248500
  • Translational

    • First-in-Human Assessment of <sup>11</sup>C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
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      First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
      Mika Naganawa, Nabeel Nabulsi, Shannan Henry, David Matuskey, Shu-Fei Lin, Lawrence Slieker, Adam J. Schwarz, Nancy Kant, Cynthia Jesudason, Kevin Ruley, Antonio Navarro, Hong Gao, Jim Ropchan, David Labaree, Richard E. Carson and Yiyun Huang
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 553-560; DOI: https://doi.org/10.2967/jnumed.120.246967
    • First-in-Human Evaluation of <sup>18</sup>F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
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      First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
      Mika Naganawa, Songye Li, Nabeel Nabulsi, Shannan Henry, Ming-Qiang Zheng, Richard Pracitto, Zhengxin Cai, Hong Gao, Michael Kapinos, David Labaree, David Matuskey, Yiyun Huang and Richard E. Carson
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 561-567; DOI: https://doi.org/10.2967/jnumed.120.249144

Pediatrics

  • Clinical

    • INVITED PERSPECTIVE

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        Dose Optimization in Pediatric Studies: Why It Is Important and How It Can Benefit Every Nuclear Medicine Department
        John O. Prior, Siroos Mirzaei, Silvano Gnesin and Marie Nicod Lalonde
        Journal of Nuclear Medicine April 1, 2021, 62 (4) 568-569; DOI: https://doi.org/10.2967/jnumed.120.254193
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      Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project
      Gian Luca Poli, Marco Coca, Leonel Torres, Frederic Fahey, Michael Lassmann, Claire-Louise Chapple, Peter Homolka and Harry Delis
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 570-576; DOI: https://doi.org/10.2967/jnumed.120.244616

Inflammation/Infection

  • Translational

    • FEATURED ARTICLE OF THE MONTH

      • First-in-Humans Study of <sup>68</sup>Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
        Open Access
        First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
        Riikka Viitanen, Olli Moisio, Petteri Lankinen, Xiang-Guo Li, Mikko Koivumäki, Sami Suilamo, Tuula Tolvanen, Kirsi Taimen, Markku Mali, Ia Kohonen, Ilpo Koskivirta, Vesa Oikonen, Helena Virtanen, Kristiina Santalahti, Anu Autio, Antti Saraste, Laura Pirilä, Pirjo Nuutila, Juhani Knuuti, Sirpa Jalkanen and Anne Roivainen
        Journal of Nuclear Medicine April 1, 2021, 62 (4) 577-583; DOI: https://doi.org/10.2967/jnumed.120.250696

Radiobiology/Dosimetry

  • Basic

    • γ-Tocotrienol–Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs
      Open Access
      γ-Tocotrienol–Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs
      Sang-gyu Lee, Teja Muralidhar Kalidindi, Hanzhi Lou, Kishore Gangangari, Blesida Punzalan, Ariana Bitton, Casey J. Lee, Hebert A. Vargas, Soobin Park, Lisa Bodei, Michael G. Kharas, Vijay K. Singh, Naga Vara Kishore Pillarsetty and Steven M. Larson
      Journal of Nuclear Medicine April 1, 2021, 62 (4) 584-590; DOI: https://doi.org/10.2967/jnumed.120.244681

Letters to the Editor

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    PET/MRI Versus PET/CT for Whole-Body Staging
    Stephen K. Gerard
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 591; DOI: https://doi.org/10.2967/jnumed.120.256453
  • You have access
    Radioguided Surgery
    Giuliano Mariani, Renato A. Valdés Olmos, Sergi Vidal-Sicart and H. William Strauss
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 591-592; DOI: https://doi.org/10.2967/jnumed.120.261888
  • You have access
    Reply: Radioguided Surgery
    Wolfgang Weber and Johannes Czernin
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 592; DOI: https://doi.org/10.2967/jnumed.121.261917

SNMMI Newsline

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    SNMMI Newsline
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N-18N;
  • You have access
    JNM Announces New Website and Social Media Sites
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N;
  • You have access
    SNMMI Launches Online Career Center
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N;
  • You have access
    SNMMI 177Lu Dosimetry Challenge 2021
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 10N;
  • You have access
    SNMMI Leadership Update: SNMMI Virtual Meetings Go Above and Beyond
    Virginia Pappas
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 11N;
  • You have access
    Newsbriefs
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 12N-13N;
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    From the Literature
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 13N-18N;
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In this issue

Journal of Nuclear Medicine: 62 (4)
Journal of Nuclear Medicine
Vol. 62, Issue 4
April 1, 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author

Issue highlights

  • Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
  • First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
  • Somatostatin Receptor–Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis
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    • Clinical
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  • Theranostics
    • Clinical
      • FEATURED CLINICAL INVESTIGATION ARTICLE
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    • Clinical
  • Cardiovascular
    • Basic
      • FEATURED BASIC SCIENCE ARTICLE
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      • INVITED PERSPECTIVE
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  • 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer
  • Deep Learning Analysis of Upright-Supine High-Efficiency SPECT Myocardial Perfusion Imaging for Prediction of Obstructive Coronary Artery Disease: A Multicenter Study
  • Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region
  • Development of Fibroblast Activation Protein–Targeted Radiotracers with Improved Tumor Retention
  • Diagnostic Evaluation of Pulmonary Embolism During the COVID-19 Pandemic
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