Journal of Nuclear Medicine: 62 (4)

April 1, 2021; Volume 62,Issue 4

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine April 1, 2021, 62 (4) 8A;

Discussions with Leaders

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Leadership in Medicine, Industry, and Innovation: A Conversation Between Jörg F. Debatin and Thomas Beyer
Jörg F. Debatin and Thomas Beyer

Journal of Nuclear Medicine April 1, 2021, 62 (4) 435-437; DOI: https://doi.org/10.2967/jnumed.121.262107

The State of the Art

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The Role of ⁸⁹Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman and Danielle J. Vugts

Journal of Nuclear Medicine April 1, 2021, 62 (4) 438-445; DOI: https://doi.org/10.2967/jnumed.119.239558

Continuing Education

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Bone Mineral Density: Clinical Relevance and Quantitative Assessment
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian and Azeez Farooki

Journal of Nuclear Medicine April 1, 2021, 62 (4) 446-454; DOI: https://doi.org/10.2967/jnumed.120.256180

Hot Topics

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Agent Optimization: Absorption, Distribution, Metabolism, Excretion, Dose, and Decay
Martin W. Brechbiel

Journal of Nuclear Medicine April 1, 2021, 62 (4) 455-456; DOI: https://doi.org/10.2967/jnumed.120.258095

Focus on Molecular Imaging

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Advances in Imaging Reactive Oxygen Species
Eli M. Espinoza, Joachim Justad Røise, I-Che Li, Riddha Das and Niren Murthy

Journal of Nuclear Medicine April 1, 2021, 62 (4) 457-461; DOI: https://doi.org/10.2967/jnumed.120.245415

Editorial

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The Evolution of PET/MR Is Hindered by Our Field’s Reluctance to Provide Critical Evaluation
Adam L. Kesner

Journal of Nuclear Medicine April 1, 2021, 62 (4) 462-463; DOI: https://doi.org/10.2967/jnumed.120.260950

Oncology

Clinical
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  Treatment Monitoring of Immunotherapy and Targeted Therapy Using ¹⁸F-FET PET in Patients with Melanoma and Lung Cancer Brain Metastases: Initial Experiences
  Norbert Galldiks, Diana S.Y. Abdulla, Matthias Scheffler, Fabian Wolpert, Jan-Michael Werner, Martin Hüllner, Gabriele Stoffels, Viola Schweinsberg, Max Schlaak, Nicole Kreuzberg, Jennifer Landsberg, Philipp Lohmann, Garry Ceccon, Christian Baues, Maike Trommer, Eren Celik, Maximilian I. Ruge, Martin Kocher, Simone Marnitz, Gereon R. Fink, Jörg-Christian Tonn, Michael Weller, Karl-Josef Langen, Jürgen Wolf and Cornelia Mauch
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 464-470; DOI: https://doi.org/10.2967/jnumed.120.248278
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  Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial
  Nils H. Nicolay, Alexander Rühle, Nicole Wiedenmann, Gabriele Niedermann, Michael Mix, Wolfgang A. Weber, Dimos Baltas, Martin Werner, Gian Kayser and Anca-L. Grosu
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 471-478; DOI: https://doi.org/10.2967/jnumed.120.248633
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  Surveillance of Clinically Complete Responders Using Serial ¹⁸F-FDG PET/CT Scans in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy
  Maria J. Valkema, Berend J. van der Wilk, Ben M. Eyck, Bas P.L. Wijnhoven, Manon C.W. Spaander, Michail Doukas, Sjoerd M. Lagarde, Wendy M.J. Schreurs, Mark J. Roef, J. Jan B. van Lanschot and Roelf Valkema
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 486-492; DOI: https://doi.org/10.2967/jnumed.120.247981
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  Phase I Study of ^99mTc-ADAPT6, a Scaffold Protein–Based Probe for Visualization of HER2 Expression in Breast Cancer
  Olga Bragina, Emma von Witting, Javad Garousi, Roman Zelchan, Mattias Sandström, Anna Orlova, Anna Medvedeva, Artem Doroshenko, Anzhelika Vorobyeva, Sarah Lindbo, Jesper Borin, Natalya Tarabanovskaya, Jens Sörensen, Sophia Hober, Vladimir Chernov and Vladimir Tolmachev
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 493-499; DOI: https://doi.org/10.2967/jnumed.120.248799
Translational
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  First Experience Using ¹⁸F-Flubrobenguane PET Imaging in Patients with Suspected Pheochromocytoma or Paraganglioma
  Lukas Kessler, Anna M. Schlitter, Markus Krönke, Alexander von Werder, Robert Tauber, Tobias Maurer, Simon Robinson, Cesare Orlandi, Michael Herz, Behrooz H. Yousefi, Stephan G. Nekolla, Markus Schwaiger, Matthias Eiber and Christoph Rischpler
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 479-485; DOI: https://doi.org/10.2967/jnumed.120.248021
Basic
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  Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation
  Manoj Kumar, Kelley Salem, Justin J. Jeffery, Yongjun Yan, Aparna M. Mahajan and Amy M. Fowler
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 500-506; DOI: https://doi.org/10.2967/jnumed.120.249508

Theranostics

Clinical
- FEATURED CLINICAL INVESTIGATION ARTICLE
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    Somatostatin Receptor–Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis
    Christian Mirian, Anne Katrine Duun-Henriksen, Andrea Maier, Maria Møller Pedersen, Lasse Rehné Jensen, Asma Bashir, Thomas Graillon, Maya Hrachova, Daniela Bota, Martjin van Essen, Petar Spanjol, Christian Kreis, Ian Law, Helle Broholm, Lars Poulsgaard, Kåre Fugleholm, Morten Ziebell, Tina Munch, Martin A. Walter and Tiit Mathiesen
    
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 507-513; DOI: https://doi.org/10.2967/jnumed.120.249607
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  High Interobserver Agreement for the Standardized Reporting System SSTR-RADS 1.0 on Somatostatin Receptor PET/CT
  Rudolf A. Werner, Thorsten Derlin, Steven P. Rowe, Lena Bundschuh, Gabriel T. Sheikh, Martin G. Pomper, Sebastian Schulz, Takahiro Higuchi, Andreas K. Buck, Frank M. Bengel, Ralph A. Bundschuh and Constantin Lapa
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 514-520; DOI: https://doi.org/10.2967/jnumed.120.245464
Basic
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  ¹⁷⁷Lu-Labeled Albumin-Binder–Conjugated PSMA-Targeting Agents with Extremely High Tumor Uptake and Enhanced Tumor-to-Kidney Absorbed Dose Ratio
  Hsiou-Ting Kuo, Kuo-Shyan Lin, Zhengxing Zhang, Carlos F. Uribe, Helen Merkens, Chengcheng Zhang and François Bénard
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 521-527; DOI: https://doi.org/10.2967/jnumed.120.250738

AI/Advanced Image Analysis

Clinical
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  Deep-Learning Generation of Synthetic Intermediate Projections Improves ¹⁷⁷Lu SPECT Images Reconstructed with Sparsely Acquired Projections
  Tobias Rydén, Martijn Van Essen, Ida Marin, Johanna Svensson and Peter Bernhardt
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 528-535; DOI: https://doi.org/10.2967/jnumed.120.245548

Cardiovascular

Basic
- FEATURED BASIC SCIENCE ARTICLE
  - Open Access
    Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with ¹⁸F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
    Mark G. MacAskill, Agne Stadulyte, Lewis Williams, Timaeus E.F. Morgan, Nikki L. Sloan, Carlos J. Alcaide-Corral, Tashfeen Walton, Catriona Wimberley, Chris-Anne McKenzie, Nick Spath, William Mungall, Ralph BouHaidar, Marc R. Dweck, Gillian A. Gray, David E. Newby, Christophe Lucatelli, Andrew Sutherland, Sally L. Pimlott and Adriana A.S. Tavares
    
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 536-544; DOI: https://doi.org/10.2967/jnumed.120.243600

Neurology

Clinical
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  Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of ¹¹C-DTBZ PET Combined with Correlational Tractography
  Carlos A. Sanchez-Catasus, Nicolaas I. Bohnen, Fang-Cheng Yeh, Nicholas D’Cruz, Prabesh Kanel and Martijn L.T.M. Müller
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 545-552; DOI: https://doi.org/10.2967/jnumed.120.248500
Translational
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  First-in-Human Assessment of ¹¹C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  Mika Naganawa, Nabeel Nabulsi, Shannan Henry, David Matuskey, Shu-Fei Lin, Lawrence Slieker, Adam J. Schwarz, Nancy Kant, Cynthia Jesudason, Kevin Ruley, Antonio Navarro, Hong Gao, Jim Ropchan, David Labaree, Richard E. Carson and Yiyun Huang
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 553-560; DOI: https://doi.org/10.2967/jnumed.120.246967
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  First-in-Human Evaluation of ¹⁸F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
  Mika Naganawa, Songye Li, Nabeel Nabulsi, Shannan Henry, Ming-Qiang Zheng, Richard Pracitto, Zhengxin Cai, Hong Gao, Michael Kapinos, David Labaree, David Matuskey, Yiyun Huang and Richard E. Carson
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 561-567; DOI: https://doi.org/10.2967/jnumed.120.249144

Pediatrics

Clinical
- INVITED PERSPECTIVE
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    Dose Optimization in Pediatric Studies: Why It Is Important and How It Can Benefit Every Nuclear Medicine Department
    John O. Prior, Siroos Mirzaei, Silvano Gnesin and Marie Nicod Lalonde
    
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 568-569; DOI: https://doi.org/10.2967/jnumed.120.254193
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  Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project
  Gian Luca Poli, Marco Coca, Leonel Torres, Frederic Fahey, Michael Lassmann, Claire-Louise Chapple, Peter Homolka and Harry Delis
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 570-576; DOI: https://doi.org/10.2967/jnumed.120.244616

Inflammation/Infection

Translational
- FEATURED ARTICLE OF THE MONTH
  - Open Access
    First-in-Humans Study of ⁶⁸Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
    Riikka Viitanen, Olli Moisio, Petteri Lankinen, Xiang-Guo Li, Mikko Koivumäki, Sami Suilamo, Tuula Tolvanen, Kirsi Taimen, Markku Mali, Ia Kohonen, Ilpo Koskivirta, Vesa Oikonen, Helena Virtanen, Kristiina Santalahti, Anu Autio, Antti Saraste, Laura Pirilä, Pirjo Nuutila, Juhani Knuuti, Sirpa Jalkanen and Anne Roivainen
    
    Journal of Nuclear Medicine April 1, 2021, 62 (4) 577-583; DOI: https://doi.org/10.2967/jnumed.120.250696

Radiobiology/Dosimetry

Basic
- Open Access
  γ-Tocotrienol–Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs
  Sang-gyu Lee, Teja Muralidhar Kalidindi, Hanzhi Lou, Kishore Gangangari, Blesida Punzalan, Ariana Bitton, Casey J. Lee, Hebert A. Vargas, Soobin Park, Lisa Bodei, Michael G. Kharas, Vijay K. Singh, Naga Vara Kishore Pillarsetty and Steven M. Larson
  
  Journal of Nuclear Medicine April 1, 2021, 62 (4) 584-590; DOI: https://doi.org/10.2967/jnumed.120.244681

Letters to the Editor

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PET/MRI Versus PET/CT for Whole-Body Staging
Stephen K. Gerard

Journal of Nuclear Medicine April 1, 2021, 62 (4) 591; DOI: https://doi.org/10.2967/jnumed.120.256453
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Radioguided Surgery
Giuliano Mariani, Renato A. Valdés Olmos, Sergi Vidal-Sicart and H. William Strauss

Journal of Nuclear Medicine April 1, 2021, 62 (4) 591-592; DOI: https://doi.org/10.2967/jnumed.120.261888
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Reply: Radioguided Surgery
Wolfgang Weber and Johannes Czernin

Journal of Nuclear Medicine April 1, 2021, 62 (4) 592; DOI: https://doi.org/10.2967/jnumed.121.261917

SNMMI Newsline

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SNMMI Newsline
Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N-18N;
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JNM Announces New Website and Social Media Sites
Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N;
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SNMMI Launches Online Career Center
Journal of Nuclear Medicine April 1, 2021, 62 (4) 9N;
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SNMMI ¹⁷⁷Lu Dosimetry Challenge 2021
Journal of Nuclear Medicine April 1, 2021, 62 (4) 10N;
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SNMMI Leadership Update: SNMMI Virtual Meetings Go Above and Beyond
Virginia Pappas

Journal of Nuclear Medicine April 1, 2021, 62 (4) 11N;
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Newsbriefs
Journal of Nuclear Medicine April 1, 2021, 62 (4) 12N-13N;
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From the Literature
Journal of Nuclear Medicine April 1, 2021, 62 (4) 13N-18N;

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Table of Contents

This Month in JNM

Discussions with Leaders

The State of the Art

Continuing Education

Hot Topics

Focus on Molecular Imaging

Editorial

Oncology

Clinical

Translational

Basic

Theranostics

Clinical

FEATURED CLINICAL INVESTIGATION ARTICLE

Basic

AI/Advanced Image Analysis

Clinical

Cardiovascular

Basic

FEATURED BASIC SCIENCE ARTICLE

Neurology

Clinical

Translational

Pediatrics

Clinical

INVITED PERSPECTIVE

Inflammation/Infection

Translational

FEATURED ARTICLE OF THE MONTH

Radiobiology/Dosimetry

Basic

Letters to the Editor

SNMMI Newsline

In this issue

Issue highlights

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