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Research ArticleInflammation/Infection
Open Access

First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

Riikka Viitanen, Olli Moisio, Petteri Lankinen, Xiang-Guo Li, Mikko Koivumäki, Sami Suilamo, Tuula Tolvanen, Kirsi Taimen, Markku Mali, Ia Kohonen, Ilpo Koskivirta, Vesa Oikonen, Helena Virtanen, Kristiina Santalahti, Anu Autio, Antti Saraste, Laura Pirilä, Pirjo Nuutila, Juhani Knuuti, Sirpa Jalkanen and Anne Roivainen
Journal of Nuclear Medicine April 2021, 62 (4) 577-583; DOI: https://doi.org/10.2967/jnumed.120.250696
Riikka Viitanen
1Turku PET Centre, University of Turku, Turku, Finland
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Olli Moisio
1Turku PET Centre, University of Turku, Turku, Finland
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Petteri Lankinen
2Department of Orthopaedics and Traumatology, Turku University Hospital and University of Turku, Turku, Finland
3Turku PET Centre, Turku University Hospital, Turku, Finland
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Xiang-Guo Li
1Turku PET Centre, University of Turku, Turku, Finland
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Mikko Koivumäki
3Turku PET Centre, Turku University Hospital, Turku, Finland
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Sami Suilamo
4Department of Medical Physics, Turku University Hospital, Turku, Finland
5Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
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Tuula Tolvanen
3Turku PET Centre, Turku University Hospital, Turku, Finland
4Department of Medical Physics, Turku University Hospital, Turku, Finland
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Kirsi Taimen
6Department of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland
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Markku Mali
6Department of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland
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Ia Kohonen
7Department of Radiology, Turku University Hospital, Turku, Finland
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Ilpo Koskivirta
6Department of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland
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Vesa Oikonen
1Turku PET Centre, University of Turku, Turku, Finland
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Helena Virtanen
1Turku PET Centre, University of Turku, Turku, Finland
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Kristiina Santalahti
8MediCity Research Laboratory, University of Turku, Turku, Finland; and
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Anu Autio
1Turku PET Centre, University of Turku, Turku, Finland
8MediCity Research Laboratory, University of Turku, Turku, Finland; and
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Antti Saraste
1Turku PET Centre, University of Turku, Turku, Finland
3Turku PET Centre, Turku University Hospital, Turku, Finland
9Heart Center, Turku University Hospital, Turku, Finland
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Laura Pirilä
6Department of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland
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Pirjo Nuutila
1Turku PET Centre, University of Turku, Turku, Finland
3Turku PET Centre, Turku University Hospital, Turku, Finland
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Juhani Knuuti
1Turku PET Centre, University of Turku, Turku, Finland
3Turku PET Centre, Turku University Hospital, Turku, Finland
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Sirpa Jalkanen
8MediCity Research Laboratory, University of Turku, Turku, Finland; and
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Anne Roivainen
1Turku PET Centre, University of Turku, Turku, Finland
3Turku PET Centre, Turku University Hospital, Turku, Finland
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Article Information

vol. 62 no. 4 577-583
DOI 
https://doi.org/10.2967/jnumed.120.250696
PubMed 
32817143

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 1, 2020
  • Accepted for publication July 9, 2020
  • Published online March 29, 2021.

Article Versions

  • previous version (August 17, 2020 - 05:27).
  • previous version (August 28, 2020 - 14:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Riikka Viitanen1,
  2. Olli Moisio1,
  3. Petteri Lankinen2,3,
  4. Xiang-Guo Li1,
  5. Mikko Koivumäki3,
  6. Sami Suilamo4,5,
  7. Tuula Tolvanen3,4,
  8. Kirsi Taimen6,
  9. Markku Mali6,
  10. Ia Kohonen7,
  11. Ilpo Koskivirta6,
  12. Vesa Oikonen1,
  13. Helena Virtanen1,
  14. Kristiina Santalahti8,
  15. Anu Autio1,8,
  16. Antti Saraste1,3,9,
  17. Laura Pirilä6,
  18. Pirjo Nuutila1,3,
  19. Juhani Knuuti1,3,
  20. Sirpa Jalkanen8 and
  21. Anne Roivainen1,3
  1. 1Turku PET Centre, University of Turku, Turku, Finland
  2. 2Department of Orthopaedics and Traumatology, Turku University Hospital and University of Turku, Turku, Finland
  3. 3Turku PET Centre, Turku University Hospital, Turku, Finland
  4. 4Department of Medical Physics, Turku University Hospital, Turku, Finland
  5. 5Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
  6. 6Department of Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland
  7. 7Department of Radiology, Turku University Hospital, Turku, Finland
  8. 8MediCity Research Laboratory, University of Turku, Turku, Finland; and
  9. 9Heart Center, Turku University Hospital, Turku, Finland
  1. For correspondence or reprints contact: Anne Roivainen, Turku PET Centre, Kiinamyllynkatu 4-8, FI-20521 Turku, Finland. E-mail: anne.roivainen{at}utu.fi
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Journal of Nuclear Medicine: 62 (4)
Journal of Nuclear Medicine
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April 1, 2021
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First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
Riikka Viitanen, Olli Moisio, Petteri Lankinen, Xiang-Guo Li, Mikko Koivumäki, Sami Suilamo, Tuula Tolvanen, Kirsi Taimen, Markku Mali, Ia Kohonen, Ilpo Koskivirta, Vesa Oikonen, Helena Virtanen, Kristiina Santalahti, Anu Autio, Antti Saraste, Laura Pirilä, Pirjo Nuutila, Juhani Knuuti, Sirpa Jalkanen, Anne Roivainen
Journal of Nuclear Medicine Apr 2021, 62 (4) 577-583; DOI: 10.2967/jnumed.120.250696

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First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
Riikka Viitanen, Olli Moisio, Petteri Lankinen, Xiang-Guo Li, Mikko Koivumäki, Sami Suilamo, Tuula Tolvanen, Kirsi Taimen, Markku Mali, Ia Kohonen, Ilpo Koskivirta, Vesa Oikonen, Helena Virtanen, Kristiina Santalahti, Anu Autio, Antti Saraste, Laura Pirilä, Pirjo Nuutila, Juhani Knuuti, Sirpa Jalkanen, Anne Roivainen
Journal of Nuclear Medicine Apr 2021, 62 (4) 577-583; DOI: 10.2967/jnumed.120.250696
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Keywords

  • dosimetry
  • 68Ga
  • kinetics
  • PET
  • vascular adhesion protein 1
  • whole-body distribution
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