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Research ArticlePediatrics

Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project

Gian Luca Poli, Marco Coca, Leonel Torres, Frederic Fahey, Michael Lassmann, Claire-Louise Chapple, Peter Homolka and Harry Delis
Journal of Nuclear Medicine April 2021, 62 (4) 570-576; DOI: https://doi.org/10.2967/jnumed.120.244616
Gian Luca Poli
1Dosimetry and Medical Radiation Physics Section, International Atomic Energy Agency, Vienna, Austria
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Marco Coca
2Medscan Nuclear Medicine and PET/CT Center, Concepcion, Chile
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Leonel Torres
3Department of Nuclear Medicine, DIC, CENTIS, Havana, Cuba
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Frederic Fahey
4Division of Nuclear Medicine, Boston Children’s Hospital, Boston, Massachusetts
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Michael Lassmann
5Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany
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Claire-Louise Chapple
6Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom; and
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Peter Homolka
7Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
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Harry Delis
1Dosimetry and Medical Radiation Physics Section, International Atomic Energy Agency, Vienna, Austria
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Figures

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  • FIGURE 1.
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    FIGURE 1.

    General scheme describing the optimization strategy.

  • FIGURE 2.
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    FIGURE 2.

    Distribution of pediatric studies at site 1 (2018) (A) and site 2 (2017) (B). MIBI = methoxyisobutylisonitrile.

  • FIGURE 3.
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    FIGURE 3.

    (A) Activities administered for 99mTc-DMSA renal cortical scans at baseline and NACG-recommended activities for same patients. Average relative difference compared with NACG-recommended values is reported for each age group. (B) Same data reported as function of weight.

  • FIGURE 4.
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    FIGURE 4.

    Activities administered to pediatric patients for 99mTc-DMSA renal cortical scans after introduction of optimization intervention. (A) Comparison, as function of age, with NACG-recommended activities for same patients. Average relative difference compared with NACG-recommended values is reported for each age group. (B) Comparison, as function of weight, with activities that would have been administered at baseline and NACG-recommended values for same patients.

  • FIGURE 5.
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    FIGURE 5.

    Baseline administered activity level for 3 example ages, simulated activity value corresponding to noise level of 23% and 25%, activity recommended by EANM, and same value increased by 50%.

  • FIGURE 6.
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    FIGURE 6.

    (A and B) Activities administered to pediatric patients for 99mTc-DMSA renal cortical scans at baseline, after introduction of optimization intervention, and EANM-recommended activities for same patients as function of age (A) and weight (B). (C) Relative difference in administered activities at baseline and after introduction of optimization intervention compared with EANM-recommended values.

Tables

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    TABLE 1

    Administered Activities for 3 Example Ages for 99mTc-DMSA Projects at Sites 1 and 2 at Baseline and After Optimization: Comparison to Recommended Values for EANM Pediatric Dosage Card and NACG

    Age (y)Weight (kg)EANMNACGSite 1 BLSite 1 OptSite 2 BLSite 2 Opt
    11018.518.5503510028
    5203337856012550
    103250591208415574
    • BL = baseline; Opt = after optimization.

    • Data are megabecquerels.

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Journal of Nuclear Medicine: 62 (4)
Journal of Nuclear Medicine
Vol. 62, Issue 4
April 1, 2021
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Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project
Gian Luca Poli, Marco Coca, Leonel Torres, Frederic Fahey, Michael Lassmann, Claire-Louise Chapple, Peter Homolka, Harry Delis
Journal of Nuclear Medicine Apr 2021, 62 (4) 570-576; DOI: 10.2967/jnumed.120.244616

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Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project
Gian Luca Poli, Marco Coca, Leonel Torres, Frederic Fahey, Michael Lassmann, Claire-Louise Chapple, Peter Homolka, Harry Delis
Journal of Nuclear Medicine Apr 2021, 62 (4) 570-576; DOI: 10.2967/jnumed.120.244616
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