Article Figures & Data
Figures
- FIGURE 1.
Coregistered axial 3D T2-weighted fast-spin echo MRI (A), 18F-choline PET (SUV range, 0–6) (B), apparent diffusion coefficient map (C), and PET/mpMRI (D). Small 0.16 cm3 right peripheral zone intermediate-risk lesion (yellow circles) was confirmed as Gleason 4+4 cancer. Respective mirrored background volume of interest (blue circles) is shown, resulting in 18F-choline TBR of 1.61. Diffusely increased 18F-choline uptake is noted in benign prostate hyperplasia (arrow).
- FIGURE 2.
Receiver-operating-characteristic curves of models L1/P1 (red line), L2/P2 (green line), L3/P3 (blue line), and L4/P4 (gray line) relative to mpMRI base-case (dashed line) for lesion-based and subject-based data, separate for readers 1 and 2 as well as Likert and PI-RADS scoring systems.
- FIGURE 3.
Bubble plot of mpMRI-identified lesions stratified by 18F-choline PET TBR and presence (red circles) or absence (blue circles) of Gleason ≥ 3+4 cancer on per-lesion basis. Circle diameter represents target volume (Supplemental Table 2). Dashed line indicates 18F-choline TBR threshold of 1.58.
- FIGURE 4.
For 56 evaluable subjects, relationship of diagnosis before study enrollment to final pathology and subsequent clinical management. Connecting lines (plain dashed: benign; solid: cancer; long-short dashed: no prior biopsy) indicate management decisions related to final pathology. ▲ = Gleason 3+3 cancer; ▼ = Gleason 3+4 cancer.
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