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Journal of Nuclear Medicine

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Meeting ReportOncology

Comparative PSMA expression at early (1hour) vs late (2hour) in primary and secondary sites of involvement in prostate cancer.

Vandita Jain, Abhishek jaiswal, vikas chaudhary and Manas sahoo
Journal of Nuclear Medicine August 2022, 63 (supplement 2) 2704;
Vandita Jain
1Medanta The Medicity Gurugram
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Abhishek jaiswal
1Medanta The Medicity Gurugram
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vikas chaudhary
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Manas sahoo
2Medanta, The Medicity
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Abstract

2704

Introduction:

Retrospective evaluation of PSMA expression by using F-18 PSMA -1007 at two different time points early (1hour) and late (2hour) in prostate cancer patients.

Methods: 40 patients (Mean Age: 69.8± 9.4 years) who underwent F-18 PSMA -1007 scan were selected for this retrospective study. F-18 PSMA-1007 PET/CT was performed for localization of biochemical relapse, primary staging or therapy follow-up. Patients were divided into two subgroups on the basis of time of acquisition (1 hour and 2 hour). Region of interests were drawn on bone marrow, liver, spleen, kidney, urinary bladder and prostate slices. Quantitative assessment of uptake of F-18PSMA-1007 in malignant lesions (SUVmax) and in normal organs (SUVmean) at both time points was done. Target to Background ratios for primary malignant lesion (lesion: normal prostate) and metastatic sites were assessed by taking into consideration of lymph nodes and skeletal lesions with liver as background for calculation.

Results: Mean TBR (Target to background ratio) was 2.3(prostate), 1.3(skeletal lesions), 1.0(lymph nodes) at 1hour whereas mean TBR was 3.5(prostate), 3.2(skeletal lesions), 1.9(lymph nodes) at 2hour.

Conclusions: Target to background ratios calculated for primary as well as secondary sites (lymph nodes and skeletal) was higher at 2 hour as compared to 1 hour. It can be concluded that performance of F-18 PSMA-1007 may be better at 2hour post injection but further evaluation with larger sample size needs to be done.

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Journal of Nuclear Medicine
Vol. 63, Issue supplement 2
August 1, 2022
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Comparative PSMA expression at early (1hour) vs late (2hour) in primary and secondary sites of involvement in prostate cancer.
Vandita Jain, Abhishek jaiswal, vikas chaudhary, Manas sahoo
Journal of Nuclear Medicine Aug 2022, 63 (supplement 2) 2704;

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Comparative PSMA expression at early (1hour) vs late (2hour) in primary and secondary sites of involvement in prostate cancer.
Vandita Jain, Abhishek jaiswal, vikas chaudhary, Manas sahoo
Journal of Nuclear Medicine Aug 2022, 63 (supplement 2) 2704;
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