Abstract
2704
Introduction:
Retrospective evaluation of PSMA expression by using F-18 PSMA -1007 at two different time points early (1hour) and late (2hour) in prostate cancer patients.
Methods: 40 patients (Mean Age: 69.8± 9.4 years) who underwent F-18 PSMA -1007 scan were selected for this retrospective study. F-18 PSMA-1007 PET/CT was performed for localization of biochemical relapse, primary staging or therapy follow-up. Patients were divided into two subgroups on the basis of time of acquisition (1 hour and 2 hour). Region of interests were drawn on bone marrow, liver, spleen, kidney, urinary bladder and prostate slices. Quantitative assessment of uptake of F-18PSMA-1007 in malignant lesions (SUVmax) and in normal organs (SUVmean) at both time points was done. Target to Background ratios for primary malignant lesion (lesion: normal prostate) and metastatic sites were assessed by taking into consideration of lymph nodes and skeletal lesions with liver as background for calculation.
Results: Mean TBR (Target to background ratio) was 2.3(prostate), 1.3(skeletal lesions), 1.0(lymph nodes) at 1hour whereas mean TBR was 3.5(prostate), 3.2(skeletal lesions), 1.9(lymph nodes) at 2hour.
Conclusions: Target to background ratios calculated for primary as well as secondary sites (lymph nodes and skeletal) was higher at 2 hour as compared to 1 hour. It can be concluded that performance of F-18 PSMA-1007 may be better at 2hour post injection but further evaluation with larger sample size needs to be done.
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