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Research ArticleMolecular Imaging

A Clinical Feasibility Study to Image Angiogenesis in Patients with Arteriovenous Malformations Using 68Ga-RGD PET/CT

Daphne Lobeek, Frédérique C.M. Bouwman, Erik H.J.G. Aarntzen, Janneke D.M. Molkenboer-Kuenen, Uta E. Flucke, Ha-Long Nguyen, Miikka Vikkula, Laurence M. Boon, Willemijn Klein, Peter Laverman, Wim J.G. Oyen, Otto C. Boerman, Samantha Y.A. Terry, Leo J. Schultze Kool and Mark Rijpkema
Journal of Nuclear Medicine February 2020, 61 (2) 270-275; DOI: https://doi.org/10.2967/jnumed.119.231167
Daphne Lobeek
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Frédérique C.M. Bouwman
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Erik H.J.G. Aarntzen
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Janneke D.M. Molkenboer-Kuenen
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Uta E. Flucke
2Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
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Ha-Long Nguyen
3Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium
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Miikka Vikkula
3Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium
4Centre for Vascular Anomalies (part of VASCERN European Reference Network), Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Laurence M. Boon
3Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium
4Centre for Vascular Anomalies (part of VASCERN European Reference Network), Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Willemijn Klein
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
5Centre for Vascular Anomalies (part of VASCERN European Reference Network), Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Peter Laverman
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Wim J.G. Oyen
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
6Department of Biomedical Sciences, Humanitas University, Milan, Italy
7Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands; and
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Otto C. Boerman
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Samantha Y.A. Terry
8Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom
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Leo J. Schultze Kool
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
5Centre for Vascular Anomalies (part of VASCERN European Reference Network), Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Mark Rijpkema
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Article Information

vol. 61 no. 2 270-275
DOI 
https://doi.org/10.2967/jnumed.119.231167
PubMed 
31519800

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 15, 2019
  • Accepted for publication July 8, 2019
  • Published online February 3, 2020.

Article Versions

  • previous version (September 13, 2019 - 09:08).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Daphne Lobeek1,
  2. Frédérique C.M. Bouwman1,
  3. Erik H.J.G. Aarntzen1,
  4. Janneke D.M. Molkenboer-Kuenen1,
  5. Uta E. Flucke2,
  6. Ha-Long Nguyen3,
  7. Miikka Vikkula3,4,
  8. Laurence M. Boon3,4,
  9. Willemijn Klein1,5,
  10. Peter Laverman1,
  11. Wim J.G. Oyen1,6,7,
  12. Otto C. Boerman1,
  13. Samantha Y.A. Terry8,
  14. Leo J. Schultze Kool1,5 and
  15. Mark Rijpkema1
  1. 1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
  2. 2Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
  3. 3Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium
  4. 4Centre for Vascular Anomalies (part of VASCERN European Reference Network), Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  5. 5Centre for Vascular Anomalies (part of VASCERN European Reference Network), Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
  6. 6Department of Biomedical Sciences, Humanitas University, Milan, Italy
  7. 7Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands; and
  8. 8Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom
  1. For correspondence or reprints contact: Daphne Lobeek, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands. E-mail: daphne.lobeek{at}radboudumc.nl
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Journal of Nuclear Medicine: 61 (2)
Journal of Nuclear Medicine
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A Clinical Feasibility Study to Image Angiogenesis in Patients with Arteriovenous Malformations Using 68Ga-RGD PET/CT
Daphne Lobeek, Frédérique C.M. Bouwman, Erik H.J.G. Aarntzen, Janneke D.M. Molkenboer-Kuenen, Uta E. Flucke, Ha-Long Nguyen, Miikka Vikkula, Laurence M. Boon, Willemijn Klein, Peter Laverman, Wim J.G. Oyen, Otto C. Boerman, Samantha Y.A. Terry, Leo J. Schultze Kool, Mark Rijpkema
Journal of Nuclear Medicine Feb 2020, 61 (2) 270-275; DOI: 10.2967/jnumed.119.231167

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A Clinical Feasibility Study to Image Angiogenesis in Patients with Arteriovenous Malformations Using 68Ga-RGD PET/CT
Daphne Lobeek, Frédérique C.M. Bouwman, Erik H.J.G. Aarntzen, Janneke D.M. Molkenboer-Kuenen, Uta E. Flucke, Ha-Long Nguyen, Miikka Vikkula, Laurence M. Boon, Willemijn Klein, Peter Laverman, Wim J.G. Oyen, Otto C. Boerman, Samantha Y.A. Terry, Leo J. Schultze Kool, Mark Rijpkema
Journal of Nuclear Medicine Feb 2020, 61 (2) 270-275; DOI: 10.2967/jnumed.119.231167
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Keywords

  • Arteriovenous malformation
  • PET/CT
  • RGD
  • integrin αvβ3
  • angiogenesis
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