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Journal of Nuclear Medicine

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Research ArticleOncology

Clinical Translation of a 68Ga-Labeled Integrin αvβ6–Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer

Xun Feng, Yanpu Wang, Dehua Lu, Xiaoxia Xu, Xin Zhou, Huiyuan Zhang, Ting Zhang, Hua Zhu, Zhi Yang, Fan Wang, Nan Li and Zhaofei Liu
Journal of Nuclear Medicine October 2020, 61 (10) 1461-1467; DOI: https://doi.org/10.2967/jnumed.119.237347
Xun Feng
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Yanpu Wang
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Dehua Lu
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Xiaoxia Xu
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Xin Zhou
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Huiyuan Zhang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Ting Zhang
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Hua Zhu
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Zhi Yang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Fan Wang
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Nan Li
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China
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Zhaofei Liu
1Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; and
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Journal of Nuclear Medicine: 61 (10)
Journal of Nuclear Medicine
Vol. 61, Issue 10
October 1, 2020
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Clinical Translation of a 68Ga-Labeled Integrin αvβ6–Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer
Xun Feng, Yanpu Wang, Dehua Lu, Xiaoxia Xu, Xin Zhou, Huiyuan Zhang, Ting Zhang, Hua Zhu, Zhi Yang, Fan Wang, Nan Li, Zhaofei Liu
Journal of Nuclear Medicine Oct 2020, 61 (10) 1461-1467; DOI: 10.2967/jnumed.119.237347

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Clinical Translation of a 68Ga-Labeled Integrin αvβ6–Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer
Xun Feng, Yanpu Wang, Dehua Lu, Xiaoxia Xu, Xin Zhou, Huiyuan Zhang, Ting Zhang, Hua Zhu, Zhi Yang, Fan Wang, Nan Li, Zhaofei Liu
Journal of Nuclear Medicine Oct 2020, 61 (10) 1461-1467; DOI: 10.2967/jnumed.119.237347
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Cited By...

  • Recent Advances in Radiotracers Targeting Novel Cancer-Specific Biomarkers in China: A Brief Overview
  • Preclinical Evaluation of 68Ga- and 177Lu-Labeled Integrin {alpha}v{beta}6-Targeting Radiotheranostic Peptides
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More in this TOC Section

Oncology

  • Comparative PSMA expression at early (1hour) vs late (2hour) in primary and secondary sites of involvement in prostate cancer.
  • Imaging spectrum of peritoneal carcinomatosis associated with various etiologies on 18F-FDG PET/CT
  • Hybrid Imaging Features of Musculoskeletal Tumors
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Translational

  • [99mTc]Tc-MY6349 Probe for Trop2-Targeted SPECT Imaging: From Preclinical to Pilot Clinical Study
  • Imaging Diverse Pathogenic Bacteria In Vivo with 18F-Fluoromannitol PET
  • Modeling Early Radiation DNA Damage Occurring During 177Lu-DOTATATE Radionuclide Therapy
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Keywords

  • pancreatic cancer
  • integrin αvβ6
  • 68Ga radiotracer
  • PET/CT
  • cycratide
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