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Research ArticleMolecular Imaging

PET Imaging of Tumor PD-L1 Expression with a Highly Specific Nonblocking Single-Domain Antibody

Gaochao Lv, Xiaorong Sun, Ling Qiu, Yan Sun, Ke Li, Qingzhu Liu, Qi Zhao, Songbing Qin and Jianguo Lin
Journal of Nuclear Medicine January 2020, 61 (1) 117-122; DOI: https://doi.org/10.2967/jnumed.119.226712
Gaochao Lv
1Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
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Xiaorong Sun
2Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
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Ling Qiu
1Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
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Yan Sun
3Smart Nuclide Biotech, Suzhou, China; and
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Ke Li
1Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
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Qingzhu Liu
1Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
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Qi Zhao
4Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou, China
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Songbing Qin
4Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou, China
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Jianguo Lin
1Key Laboratory of Nuclear Medicine of Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
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Journal of Nuclear Medicine: 61 (1)
Journal of Nuclear Medicine
Vol. 61, Issue 1
January 1, 2020
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PET Imaging of Tumor PD-L1 Expression with a Highly Specific Nonblocking Single-Domain Antibody
Gaochao Lv, Xiaorong Sun, Ling Qiu, Yan Sun, Ke Li, Qingzhu Liu, Qi Zhao, Songbing Qin, Jianguo Lin
Journal of Nuclear Medicine Jan 2020, 61 (1) 117-122; DOI: 10.2967/jnumed.119.226712

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PET Imaging of Tumor PD-L1 Expression with a Highly Specific Nonblocking Single-Domain Antibody
Gaochao Lv, Xiaorong Sun, Ling Qiu, Yan Sun, Ke Li, Qingzhu Liu, Qi Zhao, Songbing Qin, Jianguo Lin
Journal of Nuclear Medicine Jan 2020, 61 (1) 117-122; DOI: 10.2967/jnumed.119.226712
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Cited By...

  • The Role of Total-Body PET in Drug Development and Evaluation: Status and Outlook
  • Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers
  • First exploration of the on-treatment changes in tumor and organ uptake of a radiolabeled anti PD-L1 antibody during chemoradiotherapy in patients with non-small cell lung cancer using whole body PET
  • Dynamic Tumor-Specific MHC-II Immuno-PET Predicts the Efficacy of Checkpoint Inhibitor Immunotherapy in Melanoma
  • Single-Domain Antibody Theranostics on the Horizon
  • Molecular Imaging of PD-L1 Expression and Dynamics with the Adnectin-Based PET Tracer 18F-BMS-986192
  • Imaging the Cancer Immune Environment and Its Response to Pharmacologic Intervention, Part 2: The Role of Novel PET Agents
  • Immune Checkpoint Imaging in Oncology: A Game Changer Toward Personalized Immunotherapy?
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More in this TOC Section

Molecular Imaging

  • Optical Navigation of the Drop-In γ-Probe as a Means to Strengthen the Connection Between Robot-Assisted and Radioguided Surgery
  • Molecular Imaging of Very Late Antigen-4 in Acute Lung Injury
  • Preclinical Evaluation of an Engineered Single-Chain Fragment Variable-Fragment Crystallizable Targeting Human CD44
Show more Molecular Imaging

Basic

  • Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
  • Optical Navigation of the Drop-In γ-Probe as a Means to Strengthen the Connection Between Robot-Assisted and Radioguided Surgery
  • Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression
Show more Basic

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Keywords

  • Immune checkpoints
  • PD-L1
  • PET
  • Nanobody tracer
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