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Research ArticleOncology
Open Access

Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors

C. Willemien Menke-van der Houven van Oordt, Adam McGeoch, Mats Bergstrom, Iain McSherry, Deborah A. Smith, Matthew Cleveland, Wasfi Al-Azzam, Liangfu Chen, Henk Verheul, Otto S. Hoekstra, Danielle J. Vugts, Immanuel Freedman, Marc Huisman, Chris Matheny, Guus van Dongen and Sean Zhang
Journal of Nuclear Medicine July 2019, 60 (7) 902-909; DOI: https://doi.org/10.2967/jnumed.118.214726
C. Willemien Menke-van der Houven van Oordt
1Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands
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Adam McGeoch
2Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
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Mats Bergstrom
3OMID Molecular Imaging Consultancy, Uppsala, Sweden
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Iain McSherry
4Clinical Pharmacology, Science, and Study Operations, GlaxoSmithKline, Uxbridge, United Kingdom
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Deborah A. Smith
5Clin Pharm Advantage, LLC, Durham, North Carolina
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Matthew Cleveland
6Bioimaging, Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom
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Wasfi Al-Azzam
7Biopharm Product Development and Supply, GlaxoSmithKline, King of Prussia, Pennsylvania
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Liangfu Chen
8Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania
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Henk Verheul
1Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands
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Otto S. Hoekstra
9Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Danielle J. Vugts
9Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Immanuel Freedman
10Freedman Patent, Harleysville, Pennsylvania
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Marc Huisman
9Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Chris Matheny
11Oncology R&D, GlaxoSmithKline, King of Prussia, Pennsylvania; and
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Guus van Dongen
9Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Sean Zhang
12Hengrui Therapeutics, Inc., Princeton, New Jersey
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Article Information

vol. 60 no. 7 902-909
DOI 
https://doi.org/10.2967/jnumed.118.214726
PubMed 
30733323

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 18, 2018
  • Accepted for publication January 3, 2019
  • Published online July 1, 2019.

Article Versions

  • previous version (February 7, 2019 - 09:19).
  • previous version (February 22, 2019 - 13:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. C. Willemien Menke-van der Houven van Oordt*,1,
  2. Adam McGeoch*,2,
  3. Mats Bergstrom3,
  4. Iain McSherry4,
  5. Deborah A. Smith5,
  6. Matthew Cleveland6,
  7. Wasfi Al-Azzam7,
  8. Liangfu Chen8,
  9. Henk Verheul1,
  10. Otto S. Hoekstra9,
  11. Danielle J. Vugts9,
  12. Immanuel Freedman10,
  13. Marc Huisman9,
  14. Chris Matheny11,
  15. Guus van Dongen9 and
  16. Sean Zhang12
  1. 1Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands
  2. 2Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
  3. 3OMID Molecular Imaging Consultancy, Uppsala, Sweden
  4. 4Clinical Pharmacology, Science, and Study Operations, GlaxoSmithKline, Uxbridge, United Kingdom
  5. 5Clin Pharm Advantage, LLC, Durham, North Carolina
  6. 6Bioimaging, Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom
  7. 7Biopharm Product Development and Supply, GlaxoSmithKline, King of Prussia, Pennsylvania
  8. 8Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania
  9. 9Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  10. 10Freedman Patent, Harleysville, Pennsylvania
  11. 11Oncology R&D, GlaxoSmithKline, King of Prussia, Pennsylvania; and
  12. 12Hengrui Therapeutics, Inc., Princeton, New Jersey
  1. For correspondence contact: C. Willemien Menke-van der Houven van Oordt, VU University Medical Centre, Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. E-mail: c.menke{at}vumc.nl
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 60 (7)
Journal of Nuclear Medicine
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July 1, 2019
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Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors
C. Willemien Menke-van der Houven van Oordt, Adam McGeoch, Mats Bergstrom, Iain McSherry, Deborah A. Smith, Matthew Cleveland, Wasfi Al-Azzam, Liangfu Chen, Henk Verheul, Otto S. Hoekstra, Danielle J. Vugts, Immanuel Freedman, Marc Huisman, Chris Matheny, Guus van Dongen, Sean Zhang
Journal of Nuclear Medicine Jul 2019, 60 (7) 902-909; DOI: 10.2967/jnumed.118.214726

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Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors
C. Willemien Menke-van der Houven van Oordt, Adam McGeoch, Mats Bergstrom, Iain McSherry, Deborah A. Smith, Matthew Cleveland, Wasfi Al-Azzam, Liangfu Chen, Henk Verheul, Otto S. Hoekstra, Danielle J. Vugts, Immanuel Freedman, Marc Huisman, Chris Matheny, Guus van Dongen, Sean Zhang
Journal of Nuclear Medicine Jul 2019, 60 (7) 902-909; DOI: 10.2967/jnumed.118.214726
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