Research ArticlePhysics And Instrumentation

Design of Cerenkov Radiation–Assisted Photoactivation of TiO2 Nanoparticles and Reactive Oxygen Species Generation for Cancer Treatment

Shalinee Kavadiya and Pratim Biswas
Journal of Nuclear Medicine May 2019, 60 (5) 702-709; DOI: https://doi.org/10.2967/jnumed.118.215608

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Schematic diagrams of system studied for CR-assisted PDT (A) and mechanism of ROS generation and cancer cell death from CR (B). NP = nanoparticle.

  • FIGURE 2.
    FIGURE 2.

    Schematic diagram depicting model. (A) β-particle (red circle) moves (red arrow) at angle φ to line joining origin of β and TiO2 (hollow blue circle), and photon moves (turquoise arrows) at angle θ to β-trajectory. (B) Embedded Imagepart of β trajectory, showing that number of photons and photon flux to TiO2 are calculated at each step with Embedded Image. (C) Angular range of interest (peach shading).

  • FIGURE 3.
    FIGURE 3.

    (A) Number of Cerenkov photons generated as function of wavelength. (B) Comparison of model predictions to experimental results reported by Kotagiri et al. (15) and Duan et al. (23). Parameters (Embedded Image, Embedded Image, and A) taken from those studies were used to determine equivalent ROS concentration from model. # = numbers.

  • FIGURE 4.
    FIGURE 4.

    Effect of decay time (and radioactivity of 18F-FDG) on Nph (solid curve) and Nint (broken curve) (A) and on ROS concentration (B). # = numbers.

  • FIGURE 5.
    FIGURE 5.

    Effect of TiO2 concentration on Nph (solid curve) and Nint (broken curve) (A) and on ROS concentration (B). # = numbers.

  • FIGURE 6.
    FIGURE 6.

    Effect of TiO2 nanoparticle (NP) size on Nph (solid curve) and Nint (broken curve) (A) and on ROS concentration (B). # = numbers.

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