Article Figures & Data
Figures
- FIGURE 1.
Maximum-intensity-projection PET imaging sequence after 18F-FdCyd injection in patient 2. Images demonstrate physiologic uptake in liver, gallbladder, kidneys, urinary bladder, small intestine, and mildly in bone marrow. There is modest tumor uptake in histologically confirmed spindle cell carcinoma at right parapharyngeal and masticator spaces, best seen on axial PET (A) and PET/CT (B). p.i. = after injection.
- FIGURE 2.
Mean biodistribution curves plotted for percentage injected dose per gram of organ mass vs. time. (A) Organs with higher uptake. (B) Organs with lower uptake. (C) Increasing urinary bladder activity. LLI = lower large intestine; SI = small intestine; ULI = upper large intestine; %ID/g = percentage injected dose per gram of organ mass.
Tables
Site Average SD Adrenals 1.83E−02 9.30E−03 Brain 8.17E−03 2.04E−03 Breasts 1.03E−02 1.01E−02 Gallbladder wall 4.05E−02 7.55E−03 Lower large intestine wall 2.52E−02 7.82E−03 Small intestine 2.13E−02 4.57E−03 Stomach wall 1.90E−02 3.27E−03 Upper large intestine wall 2.04E−02 6.43E−03 Heart wall 1.10E−02 1.82E−03 Kidneys 5.26E−02 2.23E−02 Liver 6.02E−02 2.74E−02 Lungs 1.82E−02 7.10E−03 Muscle 1.16E−02 1.35E−03 Ovaries 1.57E−02 2.22E−03 Pancreas 1.63E−02 4.27E−03 Red marrow 1.14E−02 2.19E−03 Osteogenic cells 1.71E−02 6.41E−03 Skin 8.65E−03 1.19E−03 Spleen 1.69E−02 5.55E−03 Testes 1.03E−02 2.38E−03 Thymus 1.12E−02 3.01E−03 Thyroid 8.23E−03 4.39E−03 Urinary bladder wall 7.96E−02 5.24E−02 Uterus 1.63E−02 4.99E−03 Effective dose 2.12E−02 4.15E−03 - TABLE 2
Patient Demographics and TBR of Target Lesions on PET at 4 Time Points After Injection
TBR Age (y) Sex Diagnosis ∼9 min ∼32 min ∼56 min ∼2 h 67 M Left parotid adenosquamous cell carcinoma 1.4 1.5 1.5 1.6 30 M Right parapharyngeal spindle cell carcinoma 1.9 1.7 1.7 1.6 65 F Non–small cell lung cancer 1.4 1.4 1.5 1.7 51 F Non–small cell lung cancer 2.4 2.1 1.6 2.0 63 M Hepatocellular carcinoma NA NA NA NA NA = not applicable: patient 5’s tumor was within liver, and activity within tumor was not clearly discernable from remainder of liver parenchyma. Therefore, TBRs were not included for this subject because of concern about reporting misleading values in setting of high background/surrounding liver uptake.
