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Research ArticleOncology

Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors

Colin R. Young, Stephen Adler, Janet F. Eary, M. Liza Lindenberg, Paula M. Jacobs, Jerry Collins, Shivaani Kummar, Karen A. Kurdziel, Peter L. Choyke and Esther Mena
Journal of Nuclear Medicine April 2019, 60 (4) 492-496; DOI: https://doi.org/10.2967/jnumed.118.216994
Colin R. Young
1Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Maryland
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Stephen Adler
2Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick, Maryland
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Janet F. Eary
3Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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M. Liza Lindenberg
4Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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Paula M. Jacobs
3Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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Jerry Collins
5Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and
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Shivaani Kummar
6Stanford University School of Medicine, Palo Alto, California
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Karen A. Kurdziel
4Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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Peter L. Choyke
4Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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Esther Mena
4Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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Article Information

vol. 60 no. 4 492-496
DOI 
https://doi.org/10.2967/jnumed.118.216994
PubMed 
30389817

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 5, 2018
  • Accepted for publication September 12, 2018
  • Published online April 1, 2019.

Article Versions

  • previous version (November 2, 2018 - 07:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Colin R. Young1,
  2. Stephen Adler2,
  3. Janet F. Eary3,
  4. M. Liza Lindenberg4,
  5. Paula M. Jacobs3,
  6. Jerry Collins5,
  7. Shivaani Kummar6,
  8. Karen A. Kurdziel4,
  9. Peter L. Choyke4 and
  10. Esther Mena4
  1. 1Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Maryland
  2. 2Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick, Maryland
  3. 3Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  4. 4Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  5. 5Developmental Therapeutics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and
  6. 6Stanford University School of Medicine, Palo Alto, California
  1. For correspondence or reprints contact: Esther Mena, Molecular Imaging Program, National Cancer Institute, Building 10, Room B3B69F, Bethesda, MD 20892. E-mail: esther.menagonzalez{at}nih.gov
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Journal of Nuclear Medicine: 60 (4)
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Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors
Colin R. Young, Stephen Adler, Janet F. Eary, M. Liza Lindenberg, Paula M. Jacobs, Jerry Collins, Shivaani Kummar, Karen A. Kurdziel, Peter L. Choyke, Esther Mena
Journal of Nuclear Medicine Apr 2019, 60 (4) 492-496; DOI: 10.2967/jnumed.118.216994

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Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors
Colin R. Young, Stephen Adler, Janet F. Eary, M. Liza Lindenberg, Paula M. Jacobs, Jerry Collins, Shivaani Kummar, Karen A. Kurdziel, Peter L. Choyke, Esther Mena
Journal of Nuclear Medicine Apr 2019, 60 (4) 492-496; DOI: 10.2967/jnumed.118.216994
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Keywords

  • 18F-FdCyd
  • Tetrahydrouridine
  • PET imaging
  • cancer
  • Molecular imaging
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