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Research ArticleOncology

Sensitivity and Isoform Specificity of 18F-Fluorofuranylnorprogesterone for Measuring Progesterone Receptor Protein Response to Estradiol Challenge in Breast Cancer

Kelley Salem, Manoj Kumar, Yongjun Yan, Justin J. Jeffery, Kyle C. Kloepping, Ciara J. Michel, Ginny L. Powers, Aparna M. Mahajan and Amy M. Fowler
Journal of Nuclear Medicine February 2019, 60 (2) 220-226; DOI: https://doi.org/10.2967/jnumed.118.211516
Kelley Salem
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Manoj Kumar
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Yongjun Yan
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
2Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Justin J. Jeffery
3University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and
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Kyle C. Kloepping
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Ciara J. Michel
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Ginny L. Powers
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Aparna M. Mahajan
4Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Amy M. Fowler
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
2Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
3University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and
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Article Information

vol. 60 no. 2 220-226
DOI 
https://doi.org/10.2967/jnumed.118.211516
PubMed 
30030339

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 19, 2018
  • Accepted for publication July 13, 2018
  • Published online February 1, 2019.

Article Versions

  • previous version (July 20, 2018 - 06:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Kelley Salem1,
  2. Manoj Kumar1,
  3. Yongjun Yan1,2,
  4. Justin J. Jeffery3,
  5. Kyle C. Kloepping1,
  6. Ciara J. Michel1,
  7. Ginny L. Powers1,
  8. Aparna M. Mahajan4 and
  9. Amy M. Fowler1–3
  1. 1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
  2. 2Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
  3. 3University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and
  4. 4Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
  1. For correspondence or reprints contact: Amy M. Fowler, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave., Madison, WI 53792. E-mail: afowler{at}uwhealth.org
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Cited By...

  • 17 Citations
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy
    Farrokh Dehdashti, Ningying Wu, Cynthia X. Ma, Michael J. Naughton, John A. Katzenellenbogen, Barry A. Siegel
    Nature Communications 2021 12 1
  • Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer
    Manoj Kumar, Kelley Salem, Amye J. Tevaarwerk, Roberta M. Strigel, Amy M. Fowler
    Journal of Nuclear Medicine 2020 61 2
  • PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging
    John A. Katzenellenbogen
    Cancers 2020 12 8
  • 18F-Fluoroestradiol PET Imaging of Activating Estrogen Receptor-α Mutations in Breast Cancer
    Manoj Kumar, Kelley Salem, Ciara Michel, Justin J. Jeffery, Yongjun Yan, Amy M. Fowler
    Journal of Nuclear Medicine 2019 60 9
  • Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer
    Amy M. Fowler, Kelley Salem, Michael DeGrave, Irene M. Ong, Shane Rassman, Ginny L. Powers, Manoj Kumar, Ciara J. Michel, Aparna M. Mahajan
    Hormones and Cancer 2020 11 2
  • Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology
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    Current Pathobiology Reports 2019 7 3
  • In Vivo Receptor Visualization and Evaluation of Receptor Occupancy with Positron Emission Tomography
    Yuta Takamura, Hiroki Kakuta
    Journal of Medicinal Chemistry 2021 64 9
  • Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation
    Manoj Kumar, Kelley Salem, Justin J. Jeffery, Yongjun Yan, Aparna M. Mahajan, Amy M. Fowler
    Journal of Nuclear Medicine 2021 62 4
  • Fluorine-18 Labeled Fluorofuranylnorprogesterone ([18F]FFNP) and Dihydrotestosterone ([18F]FDHT) Prepared by “Fluorination on Sep-Pak” Method
    Falguni Basuli, Xiang Zhang, Burchelle Blackman, Margaret E. White, Elaine M. Jagoda, Peter L. Choyke, Rolf E. Swenson
    Molecules 2019 24 13
  • Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer
    Barbara Salvatore, Maria Grazia Caprio, Billy Samuel Hill, Annachiara Sarnella, Giovanni Nicola Roviello, Antonella Zannetti
    Cancers 2019 11 10

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Journal of Nuclear Medicine: 60 (2)
Journal of Nuclear Medicine
Vol. 60, Issue 2
February 1, 2019
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Sensitivity and Isoform Specificity of 18F-Fluorofuranylnorprogesterone for Measuring Progesterone Receptor Protein Response to Estradiol Challenge in Breast Cancer
Kelley Salem, Manoj Kumar, Yongjun Yan, Justin J. Jeffery, Kyle C. Kloepping, Ciara J. Michel, Ginny L. Powers, Aparna M. Mahajan, Amy M. Fowler
Journal of Nuclear Medicine Feb 2019, 60 (2) 220-226; DOI: 10.2967/jnumed.118.211516

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Sensitivity and Isoform Specificity of 18F-Fluorofuranylnorprogesterone for Measuring Progesterone Receptor Protein Response to Estradiol Challenge in Breast Cancer
Kelley Salem, Manoj Kumar, Yongjun Yan, Justin J. Jeffery, Kyle C. Kloepping, Ciara J. Michel, Ginny L. Powers, Aparna M. Mahajan, Amy M. Fowler
Journal of Nuclear Medicine Feb 2019, 60 (2) 220-226; DOI: 10.2967/jnumed.118.211516
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Cited By...

  • Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation
  • Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer
  • 18F-Fluoroestradiol PET Imaging of Activating Estrogen Receptor-{alpha} Mutations in Breast Cancer
  • Measuring Estrogen Receptor Functionality Using Progesterone Receptor PET Imaging: Rising to the (Estradiol) Challenge!
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Keywords

  • progesterone receptor
  • 18F-FFNP
  • breast cancer
  • estradiol challenge
  • PR isoforms
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