Research ArticleNeurology

Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714

Catriona Wimberley, Sonia Lavisse, Vincent Brulon, Marie-Anne Peyronneau, Claire Leroy, Benedetta Bodini, Philippe Remy, Bruno Stankoff, Irène Buvat and Michel Bottlaender
Journal of Nuclear Medicine February 2018, 59 (2) 307-314; DOI: https://doi.org/10.2967/jnumed.117.195396

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    2TC (A) and 2TC-1K (B) models (proposed by Rizzo et al. (19)). Each compartment represents pool of radioligand concentration: CPL (concentration within plasma), CND (nondisplaceable concentration), CS (concentration specifically bound within brain tissue), and CVASC (concentration within vascular compartment). Dotted line indicates concentrations captured by PET scan, and hatched area indicates vascular fraction.

  • FIGURE 2.
    FIGURE 2.

    Percentage of 2TC and 2TC-1K time–activity curves preferred by AIC for each of the 2 models before and after noise reduction.

  • FIGURE 3.
    FIGURE 3.

    Model fits for 1 representative time–activity curve with 2TC (A) and 2TC-1K (B) models. CND = nondisplaceable concentration, CS = concentration specifically bound within brain tissue, CVASC = concentration within vascular compartment.

  • FIGURE 4.
    FIGURE 4.

    Mean parameter estimates for 2TC and 2TC-1K models in some brain regions of high-affinity-binders. Parameters shown are VT (A), VND (B), and BPND (C).

  • FIGURE 5.
    FIGURE 5.

    Mean Kb estimates for 2TC-1K model for each brain region for high-affinity (A) and mixed-affinity (B) binders. GM = gray matter; WM = white matter.

  • FIGURE 6.
    FIGURE 6.

    Correlations of kinetic parameter estimates (all subjects) from 18F-DPA-714 PET scans with TSPO mRNA expression from AHB atlas. (Left) VT and BPND from 2TC. (Right) VT, BPND, and Kb from 2TC-1K. Plots surrounded by box show significant correlations.

  • FIGURE 7.
    FIGURE 7.

    Regional correlations over 25 different regions from AHB atlas between average TSPO mRNA expression (x-axis) and mRNA expression for 4 different genes specific to endothelial cells (y-axis): vascular endothelial zinc finger 1 (VEZF1) (A), forkhead box Q1 (FOXQ1) (B), platelet/endothelial cell adhesion molecule 1 (PECAM1) (C), and FMS-related tyrosine kinase 1 (FLT1) (D).

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