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Research ArticleThe State of the Art

Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care

Simon R. Cherry, Terry Jones, Joel S. Karp, Jinyi Qi, William W. Moses and Ramsey D. Badawi
Journal of Nuclear Medicine January 2018, 59 (1) 3-12; DOI: https://doi.org/10.2967/jnumed.116.184028
Simon R. Cherry
1Department of Biomedical Engineering, University of California, Davis, California
2Department of Radiology, University of California Davis Medical Center, Sacramento, California
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Terry Jones
2Department of Radiology, University of California Davis Medical Center, Sacramento, California
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Joel S. Karp
3Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania; and
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Jinyi Qi
1Department of Biomedical Engineering, University of California, Davis, California
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William W. Moses
4Lawrence Berkeley National Laboratory, Berkeley, California
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Ramsey D. Badawi
1Department of Biomedical Engineering, University of California, Davis, California
2Department of Radiology, University of California Davis Medical Center, Sacramento, California
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    FIGURE 1.

    Whole-body PET (A) vs. total-body PET (B). (Reprinted with permission of (31).)

  • FIGURE 2.
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    FIGURE 2.

    Photograph of EXPLORER mock-up installed at University of California Davis Medical Center.

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    FIGURE 3.

    Design drawing for EXPLORER PET/CT scanner. (Courtesy of United Imaging Healthcare.)

  • FIGURE 4.
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    FIGURE 4.

    Photograph of mini EXPLORER scanner (left) and maximum-intensity-projection images of 2 frames from dynamic total-body imaging study after injection of 8.5 MBq of 18F-FDG (1/10 standard activity) in 4.6-kg rhesus macaque (right).

  • FIGURE 5.
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    FIGURE 5.

    Localization through time-of-flight PET showing effect of improving timing resolution. Better timing resolution translates into higher effective sensitivity due to improved localization of each event.

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Journal of Nuclear Medicine: 59 (1)
Journal of Nuclear Medicine
Vol. 59, Issue 1
January 1, 2018
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Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care
Simon R. Cherry, Terry Jones, Joel S. Karp, Jinyi Qi, William W. Moses, Ramsey D. Badawi
Journal of Nuclear Medicine Jan 2018, 59 (1) 3-12; DOI: 10.2967/jnumed.116.184028

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Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care
Simon R. Cherry, Terry Jones, Joel S. Karp, Jinyi Qi, William W. Moses, Ramsey D. Badawi
Journal of Nuclear Medicine Jan 2018, 59 (1) 3-12; DOI: 10.2967/jnumed.116.184028
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  • Article
    • Abstract
    • FROM WHOLE-BODY PET TO TOTAL-BODY PET
    • TECHNOLOGIC DEVELOPMENT AND CHALLENGES
    • REALIZING TOTAL-BODY PET
    • APPLICATIONS FOR TOTAL-BODY PET
    • TOWARD FURTHER GAINS IN EFFECTIVE SENSITIVITY
    • SUMMARY
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
    • REFERENCES
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Keywords

  • instrumentation
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  • PET/CT
  • PET
  • total-body imaging
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