Article Figures & Data
Figures
- FIGURE 1.
Sequence of imaging during single visit.
- FIGURE 2.
Representative curve of target PETco2 (red line) and measured PETco2 (black dots) in participant at different levels of hypercapnia.
- FIGURE 3.
Measured PETco2 (A), f (B), HR (C), SBP (D), DBP (E), and RPP (F) of all participants at baseline and at different levels of hypercapnia. Results are presented as mean ± SD. P values of ≥0.05 were not significant (ns). *P < 0.05. **P < 0.01. ***P < 0.0001.
- FIGURE 4.
(A) MBF vs. RPP. (B) MFR vs. increase in PETco2. (C) Relationships between MBF and PETco2 and between adjusted MBF and PETco2. (D) Relationship between MFR and hypercapnia. Results are presented as mean ± SD. *P < 0.05. **P < 0.01.
- FIGURE 5.
MBF polar maps of representative subject, showing global MBF at baseline, during hypercapnic stimuli, and during adenosine stress.
- FIGURE 6.
Average MBF (A) and MFR (B) during initial and repeat 60-mm Hg PETco2 stress. Results are presented as mean ± SD. P values of ≥0.05 were not significant. *P < 0.05.
Tables
Parameter Baseline (n = 10) Repeat baseline (n = 10) 50 mm Hg (n = 10) 55 mm Hg (n = 9) 60 mm Hg (n = 9) Repeat 60 mm Hg (n = 8) Adenosine (n = 10) P value determined by ANOVA* PETco2 (mm Hg) 38.9 ± 2.4 N/A 49.9 ± 0.1 54.8 ± 0.3 59.4 ± 1.2 59.7 ± 0.5 N/A <0.0001 HR (beats/min) 57 ± 8 59 ± 8 62 ± 7 66 ± 9 68 ± 10 69 ± 8 76 ± 10 <0.001 f (breaths/min) 12 ± 4 N/A 17 ± 5 19 ± 4 22 ± 5 23 ± 6 N/A <0.001 SBP (mm Hg) 109 ± 13 117 ± 13 119 ± 15 123 ± 11 131 ± 12 125 ± 8 121 ± 13 <0.001 DBP (mm Hg) 65 ± 11 71 ± 11 68 ± 12 70 ± 10 74 ± 13 71 ± 7 70 ± 12 0.196 RPP (bpm × mm Hg) 6,135 ± 1,650 6,900 ± 1,165 7,140 ± 1,495 7,487 ± 1,503 8,256 ± 1,493 7,666 ± 1,240 9,123 ± 1,632 0.001 MBF (mL/min/g) 0.45 ± 0.08 0.52 ± 0.10 0.62 ± 0.20 0.76 ± 0.21 0.86 ± 0.24 0.89 ± 0.24 2.00 ± 0.34 <0.0001 Corrected MBF (mL/min/g) 0.44 ± 0.045 0.47 ± 0.09 0.51 ± 0.15 0.57 ± 0.08 0.59 ± 0.15 0.64 ± 0.19 1.37 ± 0.31 <0.0001 MFR 1.37 ± 0.317 1.68 ± 0.33 1.97 ± 0.45 2.12 ± 0.48 4.53 ± 0.70 <0.0001 ↵* Three participants for whom data were missing were excluded from repeated-measures ANOVA.
n = number of participants; N/A = not available.
Values (other than P values) are presented as mean ± SD.
