Research ArticleNeurology

Validation of the Semiquantitative Static SUVR Method for 18F-AV45 PET by Pharmacokinetic Modeling with an Arterial Input Function

Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Leonie Wyffels, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Steven Deleye, Tobi Van den Bossche, Sara Van Mossevelde, Sarah Ceyssens, Jan Versijpt, Sigrid Stroobants, Sebastiaan Engelborghs and Steven Staelens
Journal of Nuclear Medicine September 2017, 58 (9) 1483-1489; DOI: https://doi.org/10.2967/jnumed.116.184481

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    (A) Amount of unchanged 18F-AV45 (i.e., mean parent fraction ± SD, ●) at different time points after injection for all subjects investigated; black solid line represents Watabe curve fit. Colored, dotted lines represent Watabe curve fits to group-averaged parent fractions. (B) Extraction yield (EY). (C) Plasma–to–whole-blood ratios fitted with linear function. (D) Metabolite-corrected plasma input functions.

  • FIGURE 2.
    FIGURE 2.

    Regional 18F-AV45 VT (mean ± SEM) values for the 3 groups. Asterisks denote significant differences with HC group (*P < 0.05; **P < 0.01).

  • FIGURE 3.
    FIGURE 3.

    Regional 18F-AV45 SUVRCB (A) and SUVRWM (B) (mean ± SEM) values for the 3 groups. Asterisks denote significant differences with HC group (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).

  • FIGURE 4.
    FIGURE 4.

    Average spatially normalized 18F-AV45 VT (A), SUVRCB (B), and SUVRWM (C) images for the 3 groups.

  • FIGURE 5.
    FIGURE 5.

    (A) Regional 15O-water SUV (mean ± SEM) values for the 3 groups. (B) Average spatially normalized 15O-water SUV images. White arrows indicate regions with reduced flow compared with controls (parietotemporal cortex, posterior cingulate cortex, cerebellum). (C) 18F-AV45 delivery rate K1 (mean ± SEM). Asterisks denote significant differences with HC group (*P < 0.05; **P < 0.01; ****P < 0.0001).

Tables

  • TABLE 1

    Demographics, Including All Subjects

    ParameterHC (n = 10)aMCI (n = 18)AD (n = 10)
    Age (y)69 ± 673 ± 873 ± 5
    Sex
     Male497
     Female693
    Education (y)14 ± 211 ± 412 ± 4
    MMSE29 ± 125 ± 3*22 ± 4*

    • *Significantly different from controls (1-way ANOVA, corrected for multiple comparisons via Dunnett, P < 0.05).

    • MMSE = Mini-Mental State Examination.

    • Data are mean ± SD, unless otherwise stated.

  • TABLE 2

    Estimated Kinetic Parameters and VT (±SD) as Obtained by 2TCM-4k_Vb

    Brain regionVbK1k2k3k4VT
    Precuneus
     HC0.05 ± 0.010.77 ± 0.120.17 ± 0.020.02 ± 0.010.02 ± 0.018.5 ± 2.9
     aMCI0.05 ± 0.010.69 ± 0.150.14 ± 0.040.03 ± 0.010.02 ± 0.00512.1* ± 3.0
     AD0.05 ± 0.010.63* ± 0.100.13* ± 0.030.03 ± 0.010.02 ± 0.00712.6* ± 1.6
    CB
     HC0.05 ± 0.010.66 ± 0.120.17 ± 0.030.01 ± 0.010.02 ± 0.017.5 ± 2.3
     aMCI0.06 ± 0.010.65 ± 0.110.17 ± 0.030.01 ± 0.010.01 ± 0.018.3 ± 2.3
     AD0.05 ± 0.010.59 ± 0.090.16 ± 0.030.01 ± 0.0030.01 ± 0.018.3 ± 2.0
    WM
     HC0.02 ± 0.010.28 ± 0.060.14 ± 0.040.19 ± 0.100.04 ± 0.0110.9 ± 3.0
     aMCI0.02 ± 0.010.26 ± 0.050.13 ± 0.040.16 ± 0.110.03 ± 0.0211.5 ± 2.3
     AD0.02 ± 0.010.25 ± 0.040.11 ± 0.040.12* ± 0.040.03 ± 0.0110.9 ± 1.7

    • ↵* Significantly different from controls (1-way ANOVA, corrected for multiple comparisons via Dunnett, P < 0.05).

  • TABLE 3

    Pearson Correlation Coefficient of SUVRCB and SUVRWM with VT Across All Diagnostic Groups

    Brain regionVT – SUVRCBVT – SUVRWM
    Frontal lobe0.72*0.82*
    Parietal lobe0.76*0.85*
    Temporal lobe0.51†0.70*
    Occipital lobe0.69*0.79*
    Precuneus0.81*0.89*
    Anterior cingulate0.79*0.74*
    Posterior cingulate0.54‡0.63*

    • Symbols denote significant correlations (*P < 0.0001, †P = 0.002, ‡P = 0.0009).

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