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Research ArticleNeurology

Progressive Disintegration of Brain Networking from Normal Aging to Alzheimer Disease: Analysis of Independent Components of 18F-FDG PET Data

Marco Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Francesca Bongioanni, Andrea Chincarini, Gianmario Sambuceti, Cathrine Jonsson and Flavio Nobili
Journal of Nuclear Medicine July 2017, 58 (7) 1132-1139; DOI: https://doi.org/10.2967/jnumed.116.184309
Marco Pagani
1Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
2Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
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Alessandro Giuliani
3Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy
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Johanna Öberg
4Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden
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Fabrizio De Carli
5Institute of Molecular Bioimaging and Physiology, CNR, Genoa, Italy
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Silvia Morbelli
6Departments of Nuclear Medicine and Health Science, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Nicola Girtler
7Clinical Neurology, Department of Neuroscience, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
8Clinical Psychology, IRCCS AOU San Martino–IST, Genoa, Italy; and
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Dario Arnaldi
7Clinical Neurology, Department of Neuroscience, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Jennifer Accardo
7Clinical Neurology, Department of Neuroscience, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Matteo Bauckneht
6Departments of Nuclear Medicine and Health Science, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Francesca Bongioanni
6Departments of Nuclear Medicine and Health Science, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Andrea Chincarini
9National Institute of Nuclear Physics, Genoa, Italy
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Gianmario Sambuceti
6Departments of Nuclear Medicine and Health Science, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Cathrine Jonsson
4Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden
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Flavio Nobili
7Clinical Neurology, Department of Neuroscience, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
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Article Information

vol. 58 no. 7 1132-1139
DOI 
https://doi.org/10.2967/jnumed.116.184309
PubMed 
28280223

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 27, 2016
  • Accepted for publication December 1, 2016
  • Published online July 3, 2017.

Article Versions

  • previous version (March 9, 2017 - 05:16).
  • previous version (March 16, 2017 - 04:46).
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Copyright & Usage 
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Marco Pagani1,2,
  2. Alessandro Giuliani3,
  3. Johanna Öberg4,
  4. Fabrizio De Carli5,
  5. Silvia Morbelli6,
  6. Nicola Girtler7,8,
  7. Dario Arnaldi7,
  8. Jennifer Accardo7,
  9. Matteo Bauckneht6,
  10. Francesca Bongioanni6,
  11. Andrea Chincarini9,
  12. Gianmario Sambuceti6,
  13. Cathrine Jonsson4 and
  14. Flavio Nobili7
  1. 1Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
  2. 2Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
  3. 3Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy
  4. 4Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden
  5. 5Institute of Molecular Bioimaging and Physiology, CNR, Genoa, Italy
  6. 6Departments of Nuclear Medicine and Health Science, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
  7. 7Clinical Neurology, Department of Neuroscience, University of Genoa, and IRCCS AOU San Martino–IST, Genoa, Italy
  8. 8Clinical Psychology, IRCCS AOU San Martino–IST, Genoa, Italy; and
  9. 9National Institute of Nuclear Physics, Genoa, Italy
  1. For correspondence or reprints contact: Marco Pagani, Institute of Cognitive Sciences and Technologies, CNR, Via Palestro 32, 00185 Rome, Italy. E-mail: marco.pagani{at}istc.cnr.it
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Journal of Nuclear Medicine: 58 (7)
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Progressive Disintegration of Brain Networking from Normal Aging to Alzheimer Disease: Analysis of Independent Components of 18F-FDG PET Data
Marco Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Francesca Bongioanni, Andrea Chincarini, Gianmario Sambuceti, Cathrine Jonsson, Flavio Nobili
Journal of Nuclear Medicine Jul 2017, 58 (7) 1132-1139; DOI: 10.2967/jnumed.116.184309

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Progressive Disintegration of Brain Networking from Normal Aging to Alzheimer Disease: Analysis of Independent Components of 18F-FDG PET Data
Marco Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Francesca Bongioanni, Andrea Chincarini, Gianmario Sambuceti, Cathrine Jonsson, Flavio Nobili
Journal of Nuclear Medicine Jul 2017, 58 (7) 1132-1139; DOI: 10.2967/jnumed.116.184309
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Keywords

  • 18F-FDG PET
  • independent-component analysis
  • normal aging
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