FIGURE 1.

Research ArticleNeurology

Kinetic Modeling of the Tau PET Tracer ¹⁸F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

Olivier Barret, David Alagille, Sandra Sanabria, Robert A. Comley, Robby M. Weimer, Edilio Borroni, Mark Mintun, Nicholas Seneca, Caroline Papin, Thomas Morley, Ken Marek, John P. Seibyl, Gilles D. Tamagnan and Danna Jennings

Journal of Nuclear Medicine July 2017, 58 (7) 1124-1131; DOI: https://doi.org/10.2967/jnumed.116.182881

Olivier Barret

1Molecular NeuroImaging LLC, New Haven, Connecticut

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David Alagille

1Molecular NeuroImaging LLC, New Haven, Connecticut

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Sandra Sanabria

2Genentech Research and Early Development, Genentech, South San Francisco, California

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Robert A. Comley

3Pharma Research and Early Development, F. Hoffmann-La Roche, Konzern-Hauptsitz, Basel, Switzerland

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Robby M. Weimer

2Genentech Research and Early Development, Genentech, South San Francisco, California

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Edilio Borroni

3Pharma Research and Early Development, F. Hoffmann-La Roche, Konzern-Hauptsitz, Basel, Switzerland

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Mark Mintun

4Avid Radiopharmaceuticals, Philadelphia, Pennsylvania; and

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Nicholas Seneca

5Product Development, F. Hoffmann-La Roche, Konzern-Hauptsitz, Basel, Switzerland

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Caroline Papin

1Molecular NeuroImaging LLC, New Haven, Connecticut

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Thomas Morley

1Molecular NeuroImaging LLC, New Haven, Connecticut

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Ken Marek

1Molecular NeuroImaging LLC, New Haven, Connecticut

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John P. Seibyl

1Molecular NeuroImaging LLC, New Haven, Connecticut

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Gilles D. Tamagnan

1Molecular NeuroImaging LLC, New Haven, Connecticut

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Danna Jennings

1Molecular NeuroImaging LLC, New Haven, Connecticut

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FIGURE 1.

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FIGURE 1.

¹⁸F-AV-1451 SUVR images (80–100 min) superimposed onto subject’s MR image in transaxial (top row) and coronal (bottom row) views in 1 YHV, 1 AHV, and 3 AD subjects.

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Journal of Nuclear Medicine

Vol. 66, Issue 6

June 1, 2025

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Kinetic Modeling of the Tau PET Tracer ¹⁸F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

Journal of Nuclear Medicine Jul 2017, 58 (7) 1124-1131; DOI: 10.2967/jnumed.116.182881

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Kinetic Modeling of the Tau PET Tracer ¹⁸F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

Journal of Nuclear Medicine Jul 2017, 58 (7) 1124-1131; DOI: 10.2967/jnumed.116.182881

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Keywords

Tau protein
Alzheimer
PET
18F-AV-1451
kinetic modeling

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Kinetic Modeling of the Tau PET Tracer ¹⁸F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

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Kinetic Modeling of the Tau PET Tracer ¹⁸F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects