In Vivo Evaluation of 11C-Preladenant for PET Imaging of Adenosine A2A Receptors in the Conscious Monkey

Xiaoyun Zhou; Ronald Boellaard; Kiichi Ishiwata; Muneyuki Sakata; Rudi A.J.O. Dierckx; Johan R. de Jong; Shingo Nishiyama; Hiroyuki Ohba; Hideo Tsukada; Erik F.J. de Vries; Philip H. Elsinga

doi:10.2967/jnumed.116.182410

Research ArticleNeurology

In Vivo Evaluation of ¹¹C-Preladenant for PET Imaging of Adenosine A_2A Receptors in the Conscious Monkey

Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A.J.O. Dierckx, Johan R. de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F.J. de Vries and Philip H. Elsinga

Journal of Nuclear Medicine May 2017, 58 (5) 762-767; DOI: https://doi.org/10.2967/jnumed.116.182410

Xiaoyun Zhou

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Ronald Boellaard

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Kiichi Ishiwata

2Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

3Institute of Cyclotron and Drug Discovery Research, Southern TOHOKU Research Institute for Neuroscience, Koriyama, Japan

4Department of Biofunctional Imaging, Fukushima Medical University, Fukushima, Japan; and

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Muneyuki Sakata

2Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

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Rudi A.J.O. Dierckx

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Johan R. de Jong

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Shingo Nishiyama

5Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan

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Hiroyuki Ohba

5Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan

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Hideo Tsukada

5Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan

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Erik F.J. de Vries

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Philip H. Elsinga

1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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In Vivo Evaluation of ¹¹C-Preladenant for PET Imaging of Adenosine A_2A Receptors in the Conscious Monkey

Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A.J.O. Dierckx, Johan R. de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F.J. de Vries, Philip H. Elsinga

Journal of Nuclear Medicine May 2017, 58 (5) 762-767; DOI: 10.2967/jnumed.116.182410

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In Vivo Evaluation of ¹¹C-Preladenant for PET Imaging of Adenosine A_2A Receptors in the Conscious Monkey

Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A.J.O. Dierckx, Johan R. de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F.J. de Vries, Philip H. Elsinga

Journal of Nuclear Medicine May 2017, 58 (5) 762-767; DOI: 10.2967/jnumed.116.182410

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Keywords

adenosine A2A receptors
PET
11C-preladenant
pharmacokinetic modeling
monkey

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In Vivo Evaluation of ¹¹C-Preladenant for PET Imaging of Adenosine A_2A Receptors in the Conscious Monkey

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