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Research ArticleOncology

Safety, Dosimetry, and Tumor Detection Ability of 68Ga-NOTA-AE105: First-in-Human Study of a Novel Radioligand for uPAR PET Imaging

Dorthe Skovgaard, Morten Persson, Malene Brandt-Larsen, Camilla Christensen, Jacob Madsen, Thomas Levin Klausen, Søren Holm, Flemming Littrup Andersen, Annika Loft, Anne Kiil Berthelsen, Helle Pappot, Klaus Brasso, Niels Kroman, Liselotte Højgaard and Andreas Kjaer
Journal of Nuclear Medicine March 2017, 58 (3) 379-386; DOI: https://doi.org/10.2967/jnumed.116.178970
Dorthe Skovgaard
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Morten Persson
2Curasight, Copenhagen, Denmark
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Malene Brandt-Larsen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Camilla Christensen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Jacob Madsen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Thomas Levin Klausen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Søren Holm
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Flemming Littrup Andersen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Annika Loft
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Anne Kiil Berthelsen
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Helle Pappot
3Department of Oncology, Rigshospitalet, Copenhagen, Denmark
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Klaus Brasso
4Department of Urology, Copenhagen Prostate Cancer Center, Rigshospitalet, Copenhagen, Denmark; and
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Niels Kroman
5Department of Plastic Surgery, Breast Surgery and Burns Treatment, Rigshospitalet, Copenhagen, Denmark
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Liselotte Højgaard
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Andreas Kjaer
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
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Article Information

vol. 58 no. 3 379-386
DOI 
https://doi.org/10.2967/jnumed.116.178970
PubMed 
27609788

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 31, 2016
  • Accepted for publication August 18, 2016
  • Published online March 1, 2017.

Article Versions

  • previous version (September 8, 2016 - 05:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Dorthe Skovgaard*,1,
  2. Morten Persson*,2,
  3. Malene Brandt-Larsen1,
  4. Camilla Christensen1,
  5. Jacob Madsen1,
  6. Thomas Levin Klausen1,
  7. Søren Holm1,
  8. Flemming Littrup Andersen1,
  9. Annika Loft1,
  10. Anne Kiil Berthelsen1,
  11. Helle Pappot3,
  12. Klaus Brasso4,
  13. Niels Kroman5,
  14. Liselotte Højgaard1 and
  15. Andreas Kjaer1
  1. 1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
  2. 2Curasight, Copenhagen, Denmark
  3. 3Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  4. 4Department of Urology, Copenhagen Prostate Cancer Center, Rigshospitalet, Copenhagen, Denmark; and
  5. 5Department of Plastic Surgery, Breast Surgery and Burns Treatment, Rigshospitalet, Copenhagen, Denmark
  1. For correspondence or reprints contact: Andreas Kjaer, Department of Clinical Physiology, Nuclear Medicine & PET, KF-4012, Rigshospitalet, National University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark. E-mail: akjaer{at}sund.ku.dk
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Journal of Nuclear Medicine: 58 (3)
Journal of Nuclear Medicine
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March 1, 2017
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Safety, Dosimetry, and Tumor Detection Ability of 68Ga-NOTA-AE105: First-in-Human Study of a Novel Radioligand for uPAR PET Imaging
Dorthe Skovgaard, Morten Persson, Malene Brandt-Larsen, Camilla Christensen, Jacob Madsen, Thomas Levin Klausen, Søren Holm, Flemming Littrup Andersen, Annika Loft, Anne Kiil Berthelsen, Helle Pappot, Klaus Brasso, Niels Kroman, Liselotte Højgaard, Andreas Kjaer
Journal of Nuclear Medicine Mar 2017, 58 (3) 379-386; DOI: 10.2967/jnumed.116.178970

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Safety, Dosimetry, and Tumor Detection Ability of 68Ga-NOTA-AE105: First-in-Human Study of a Novel Radioligand for uPAR PET Imaging
Dorthe Skovgaard, Morten Persson, Malene Brandt-Larsen, Camilla Christensen, Jacob Madsen, Thomas Levin Klausen, Søren Holm, Flemming Littrup Andersen, Annika Loft, Anne Kiil Berthelsen, Helle Pappot, Klaus Brasso, Niels Kroman, Liselotte Højgaard, Andreas Kjaer
Journal of Nuclear Medicine Mar 2017, 58 (3) 379-386; DOI: 10.2967/jnumed.116.178970
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Keywords

  • molecular imaging
  • oncology
  • general
  • PET/CT
  • 68Ga-NOTA-AE105
  • First in humans
  • phase I
  • uPAR PET
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