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Research ArticleOncology

In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow

Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman and Frank N. van Leeuwen
Journal of Nuclear Medicine February 2017, 58 (2) 214-220; DOI: https://doi.org/10.2967/jnumed.116.177741
Laurens T. van der Meer
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Samantha Y.A. Terry
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
3Division of Imaging Sciences and Biomedical Engineering, Department of Imaging Chemistry and Biology, King’s College London, London, United Kingdom
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Dorette S. van Ingen Schenau
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Kiki C. Andree
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Gerben M. Franssen
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Debbie M. Roeleveld
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
4Experimental Rheumatology, Radboud Insititute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Josbert M. Metselaar
5Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH-Aachen University, Aachen, Germany
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Thomas Reinheckel
6Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany
7German Cancer Consortium (DKTK), Freiburg, Germany
8BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University, Freiburg, Germany; and
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Peter M. Hoogerbrugge
9Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Otto C. Boerman
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Frank N. van Leeuwen
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Article Information

vol. 58 no. 2 214-220
DOI 
https://doi.org/10.2967/jnumed.116.177741
PubMed 
27493268

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 23, 2016
  • Accepted for publication July 25, 2016
  • Published online February 1, 2017.

Article Versions

  • previous version (August 4, 2016 - 05:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Laurens T. van der Meer*,1,
  2. Samantha Y.A. Terry*,2,3,
  3. Dorette S. van Ingen Schenau1,
  4. Kiki C. Andree1,
  5. Gerben M. Franssen2,
  6. Debbie M. Roeleveld1,4,
  7. Josbert M. Metselaar5,
  8. Thomas Reinheckel6–8,
  9. Peter M. Hoogerbrugge9,
  10. Otto C. Boerman2 and
  11. Frank N. van Leeuwen1
  1. 1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
  2. 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
  3. 3Division of Imaging Sciences and Biomedical Engineering, Department of Imaging Chemistry and Biology, King’s College London, London, United Kingdom
  4. 4Experimental Rheumatology, Radboud Insititute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
  5. 5Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH-Aachen University, Aachen, Germany
  6. 6Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany
  7. 7German Cancer Consortium (DKTK), Freiburg, Germany
  8. 8BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University, Freiburg, Germany; and
  9. 9Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands
  1. For correspondence or reprints contact: Frank N. van Leeuwen, 412 Laboratory of Pediatric Oncology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: FrankN.vanleeuwen{at}radboudumc.nl
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Journal of Nuclear Medicine: 58 (2)
Journal of Nuclear Medicine
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February 1, 2017
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In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman, Frank N. van Leeuwen
Journal of Nuclear Medicine Feb 2017, 58 (2) 214-220; DOI: 10.2967/jnumed.116.177741

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In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman, Frank N. van Leeuwen
Journal of Nuclear Medicine Feb 2017, 58 (2) 214-220; DOI: 10.2967/jnumed.116.177741
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Keywords

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