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Journal of Nuclear Medicine

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Table of Contents

February 1, 2017; Volume 58,Issue 2

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 8A;

SNMMI Newsline

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    2016 SNMMI Highlights Lecture: Oncology, Part 2
    Wolfgang A. Weber
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 9N-15N;
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    ICRT 2016: International Focus on Theragnostics
    Suresh C. Srivastava
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 16N;
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    In Memoriam: Evelyn E. Watson, 1928–2016
    Pat B. Zanzonico
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 17N;
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    Commentary: NRC Requests Comments on Draft Guidance
    Jeffry A. Siegel, Michael G. Stabin and Carol S. Marcus
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 18N;
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    SNMMI Leadership Update: Expanding Outreach in the Era of Integrated, Collaborative Health Care
    Virginia Pappas
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 19N;

The State of the Art

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    Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
    Wolf-Dieter Heiss and Olivier Zaro Weber
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 187-193; DOI: https://doi.org/10.2967/jnumed.116.185975

Invited Perspectives

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    Citius, Altius, Fortius: An Olympian Dream for Theranostics
    Rodney J. Hicks
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 194-195; DOI: https://doi.org/10.2967/jnumed.116.182188
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    Metabolic Tumor Volume: We Still Need a Platinum-Standard Metric
    Andrea Gallamini and Lale Kostakoglu
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 196-197; DOI: https://doi.org/10.2967/jnumed.116.184663

Editorials

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    Small Data: A Ubiquitous, Yet Untapped, Resource for Low-Cost Imaging Innovation
    Adam L. Kesner and Wolfgang A. Weber
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 198-200; DOI: https://doi.org/10.2967/jnumed.116.177303

Continuing Education

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    Quantification of Lung PET Images: Challenges and Opportunities
    Delphine L. Chen, Joseph Cheriyan, Edwin R. Chilvers, Gourab Choudhury, Christopher Coello, Martin Connell, Marie Fisk, Ashley M. Groves, Roger N. Gunn, Beverley F. Holman, Brian F. Hutton, Sarah Lee, William MacNee, Divya Mohan, David Parr, Deepak Subramanian, Ruth Tal-Singer, Kris Thielemans, Edwin J.R. van Beek, Laurence Vass, Jeremy W. Wellen, Ian Wilkinson and Frederick J. Wilson
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 201-207; DOI: https://doi.org/10.2967/jnumed.116.184796

Oncology

  • Basic

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      Assessment of Tryptophan Uptake and Kinetics Using 1-(2-18F-Fluoroethyl)-l-Tryptophan and α-11C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts
      Sharon K. Michelhaugh, Otto Muzik, Anthony R. Guastella, Neil V. Klinger, Lisa A. Polin, Hancheng Cai, Yangchun Xin, Thomas J. Mangner, Shaohui Zhang, Csaba Juhász and Sandeep Mittal
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 208-213; DOI: https://doi.org/10.2967/jnumed.116.179994
    • FEATURED BASIC SCIENCE ARTICLE

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        In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
        Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman and Frank N. van Leeuwen
        Journal of Nuclear Medicine February 1, 2017, 58 (2) 214-220; DOI: https://doi.org/10.2967/jnumed.116.177741
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      Enhancing Expression of Functional Human Sodium Iodide Symporter and Somatostatin Receptor in Recombinant Oncolytic Vaccinia Virus for In Vivo Imaging of Tumors
      Jiahu Wang, Rozanne Arulanandam, Richard Wassenaar, Theresa Falls, Julia Petryk, Judith Paget, Kenneth Garson, Catia Cemeus, Barbara C. Vanderhyden, R. Glenn Wells, John C. Bell and Fabrice Le Boeuf
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 221-227; DOI: https://doi.org/10.2967/jnumed.116.180463
  • Translational

    • FEATURED ARTICLE OF THE MONTH

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        Clinical Translation of a Dual Integrin αvβ3– and Gastrin-Releasing Peptide Receptor–Targeting PET Radiotracer, 68Ga-BBN-RGD
        Jingjing Zhang, Gang Niu, Lixin Lang, Fang Li, Xinrong Fan, Xuefeng Yan, Shaobo Yao, Weigang Yan, Li Huo, Libo Chen, Zhiyuan Li, Zhaohui Zhu and Xiaoyuan Chen
        Journal of Nuclear Medicine February 1, 2017, 58 (2) 228-234; DOI: https://doi.org/10.2967/jnumed.116.177048
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      Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer
      Stephanie Robu, Margret Schottelius, Matthias Eiber, Tobias Maurer, Jürgen Gschwend, Markus Schwaiger and Hans-Jürgen Wester
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 235-242; DOI: https://doi.org/10.2967/jnumed.116.178939
  • Clinical

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      Comparison of Intraoperative γ-Probe Imaging and Postoperative SPECT/CT in Detection of Sentinel Nodes Related to the Ovary
      Stéphanie C.J.M. Speth, Roy F.P.M. Kruitwagen, Marjolein Kleppe, Ivo N.A. Pooters, Toon Van Gorp, Brigitte F.M. Slangen and Boudewijn Brans
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 243-245; DOI: https://doi.org/10.2967/jnumed.116.183426
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      Characterizing the Utility and Limitations of Repurposing an Open-Field Optical Imaging Device for Fluorescence-Guided Surgery in Head and Neck Cancer Patients
      Lindsay S. Moore, Eben L. Rosenthal, Thomas K. Chung, Esther de Boer, Neel Patel, Andrew C. Prince, Melissa L. Korb, Erika M. Walsh, E. Scott Young, Todd M. Stevens, Kirk P. Withrow, Anthony B. Morlandt, Joshua S. Richman, William R. Carroll, Kurt R. Zinn and Jason M. Warram
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 246-251; DOI: https://doi.org/10.2967/jnumed.115.171413
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      Rate of Distant Metastases on 18F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years
      Vincent Lebon, Jean-Louis Alberini, Jean-Yves Pierga, Véronique Diéras, Nina Jehanno and Myriam Wartski
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 252-257; DOI: https://doi.org/10.2967/jnumed.116.178749
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      TERT Promoter Mutation Predicts Radioiodine-Refractory Character in Distant Metastatic Differentiated Thyroid Cancer
      Xue Yang, Jiao Li, Xiaoyi Li, Zhiyong Liang, Wen Gao, Jun Liang, Shujun Cheng and Yansong Lin
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 258-265; DOI: https://doi.org/10.2967/jnumed.116.180240
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      Predicting Pathologic Response of Esophageal Cancer to Neoadjuvant Chemotherapy: The Implications of Metabolic Nodal Response for Personalized Therapy
      John M. Findlay, Kevin M. Bradley, Lai Mun Wang, James M. Franklin, Eugene J. Teoh, Fergus V. Gleeson, Nicholas D. Maynard, Richard S. Gillies and Mark R. Middleton
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 266-275; DOI: https://doi.org/10.2967/jnumed.116.176313
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      Baseline Total Metabolic Tumor Volume Measured with Fixed or Different Adaptive Thresholding Methods Equally Predicts Outcome in Peripheral T Cell Lymphoma
      Anne-Ségolène Cottereau, Sebastien Hapdey, Loic Chartier, Romain Modzelewski, Olivier Casasnovas, Emmanuel Itti, Herve Tilly, Pierre Vera, Michel A. Meignan and Stéphanie Becker
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 276-281; DOI: https://doi.org/10.2967/jnumed.116.180406
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      Correlation Between SUVmax and CT Radiomic Analysis Using Lymph Node Density in PET/CT-Based Lymph Node Staging
      Frederik L. Giesel, Florian Schneider, Clemens Kratochwil, Daniel Rath, Jan Moltz, Tim Holland-Letz, Hans-Ulrich Kauczor, Lawrence H. Schwartz, Uwe Haberkorn and Paul Flechsig
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 282-287; DOI: https://doi.org/10.2967/jnumed.116.179648

Theranostics

  • Basic

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      NAMPT Inhibitor GMX1778 Enhances the Efficacy of 177Lu-DOTATATE Treatment of Neuroendocrine Tumors
      Anna-Karin Elf, Peter Bernhardt, Tobias Hofving, Yvonne Arvidsson, Eva Forssell-Aronsson, Bo Wängberg, Ola Nilsson and Viktor Johanson
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 288-292; DOI: https://doi.org/10.2967/jnumed.116.177584
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      68Ga/177Lu-NeoBOMB1, a Novel Radiolabeled GRPR Antagonist for Theranostic Use in Oncology
      Simone U. Dalm, Ingrid L. Bakker, Erik de Blois, Gabriela N. Doeswijk, Mark W. Konijnenberg, Francesca Orlandi, Donato Barbato, Mattia Tedesco, Theodosia Maina, Berthold A. Nock and Marion de Jong
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 293-299; DOI: https://doi.org/10.2967/jnumed.116.176636
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      Highly Increased 125I-JR11 Antagonist Binding In Vitro Reveals Novel Indications for sst2 Targeting in Human Cancers
      Jean Claude Reubi, Beatrice Waser, Helmut Mäcke and Jean Rivier
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 300-306; DOI: https://doi.org/10.2967/jnumed.116.177733
  • Clinical

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      68Ga-DOTATATE PET/CT Interobserver Agreement for Neuroendocrine Tumor Assessment: Results of a Prospective Study on 50 Patients
      Wolfgang Peter Fendler, Martin Barrio, Claudio Spick, Martin Allen-Auerbach, Valentina Ambrosini, Matthias Benz, Christina Bluemel, Ravinder Kaur Grewal, Constantin Lapa, Matthias Miederer, Guillaume Nicolas, Tibor Schuster, Johannes Czernin and Ken Herrmann
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 307-311; DOI: https://doi.org/10.2967/jnumed.116.179192
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      Predictors of Response to Radioligand Therapy of Metastatic Castrate-Resistant Prostate Cancer with 177Lu-PSMA-617
      Justin Ferdinandus, Elisabeth Eppard, Florian C. Gaertner, Stefan Kürpig, Rolf Fimmers, Anna Yordanova, Stefan Hauser, Georg Feldmann, Markus Essler and Hojjat Ahmadzadehfar
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 312-319; DOI: https://doi.org/10.2967/jnumed.116.178228

Neurology

  • Basic

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      11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain
      Masamichi Ikawa, Talakad G. Lohith, Stal Shrestha, Sanjay Telu, Sami S. Zoghbi, Sabrina Castellano, Sabrina Taliani, Federico Da Settimo, Masahiro Fujita, Victor W. Pike and Robert B. Innis; the Biomarkers Consortium Radioligand Project Team
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 320-325; DOI: https://doi.org/10.2967/jnumed.116.178996
  • Clinical

    • FEATURED CLINICAL INVESTIGATION ARTICLE

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        2-Year Natural Decline of Cardiac Sympathetic Innervation in Idiopathic Parkinson Disease Studied with 11C-Hydroxyephedrine PET
        Ka Kit Wong, David M. Raffel, Nicolaas I. Bohnen, Gulcin Altinok, Sid Gilman and Kirk A. Frey
        Journal of Nuclear Medicine February 1, 2017, 58 (2) 326-331; DOI: https://doi.org/10.2967/jnumed.116.176891
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      Reference Tissue–Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
      Suzanne L. Baker, Samuel N. Lockhart, Julie C. Price, Mark He, Ronald H. Huesman, Daniel Schonhaut, Jamie Faria, Gil Rabinovici and William J. Jagust
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 332-338; DOI: https://doi.org/10.2967/jnumed.116.175273

Radiation Biology

  • Basic

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      Monte Carlo N-Particle (MCNP) Modeling of the Cellular Dosimetry of 64Cu: Comparison with MIRDcell S Values and Implications for Studies of Its Cytotoxic Effects
      Zhongli Cai, Yongkyu Luke Kwon and Raymond M. Reilly
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 339-345; DOI: https://doi.org/10.2967/jnumed.116.175695
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      Microarray Studies on 211At Administration in BALB/c Nude Mice Indicate Systemic Effects on Transcriptional Regulation in Nonthyroid Tissues
      Britta Langen, Nils Rudqvist, Khalil Helou and Eva Forssell-Aronsson
      Journal of Nuclear Medicine February 1, 2017, 58 (2) 346-353; DOI: https://doi.org/10.2967/jnumed.116.176958

Letters to the Editor

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    THYROPET Study: Is It Biology or Technology That Is the Issue?
    David A. Pattison and Rodney J. Hicks
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 354; DOI: https://doi.org/10.2967/jnumed.116.181420
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    Reply: THYROPET Study: Is It Biology or Technology That Is the Issue?
    Jakob W. Kist, Bart de Keizer, Otto S. Hoekstra and Wouter V. Vogel
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 354-355; DOI: https://doi.org/10.2967/jnumed.116.181685

Errata

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    Erratum
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 356;
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    Erratum
    Journal of Nuclear Medicine February 1, 2017, 58 (2) 356;
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In this issue

Journal of Nuclear Medicine: 58 (2)
Journal of Nuclear Medicine
Vol. 58, Issue 2
February 1, 2017
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author

Issue highlights

  • Clinical Translation of a Dual Integrin αvβ3– and Gastrin-Releasing Peptide Receptor–Targeting PET Radiotracer, 68Ga-BBN-RGD
  • In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
  • 2-Year Natural Decline of Cardiac Sympathetic Innervation in Idiopathic Parkinson Disease Studied with 11C-Hydroxyephedrine PET
  • Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
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      • FEATURED BASIC SCIENCE ARTICLE
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      • FEATURED ARTICLE OF THE MONTH
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  • Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of 177Lu-PSMA-617 Theranostics in Metastatic Castration-Resistant Prostate Cancer
  • First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  • Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single-Center Study
  • Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study
  • Radiation Dosimetry in 177Lu-PSMA-617 Therapy Using a Single Posttreatment SPECT/CT Scan: A Novel Methodology to Generate Time- and Tissue-Specific Dose Factors
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