Research ArticleOncology
In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman and Frank N. van Leeuwen
Journal of Nuclear Medicine February 2017, 58 (2) 214-220; DOI: https://doi.org/10.2967/jnumed.116.177741
Laurens T. van der Meer
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Samantha Y.A. Terry
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
3Division of Imaging Sciences and Biomedical Engineering, Department of Imaging Chemistry and Biology, King’s College London, London, United Kingdom
Dorette S. van Ingen Schenau
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Kiki C. Andree
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Gerben M. Franssen
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Debbie M. Roeleveld
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
4Experimental Rheumatology, Radboud Insititute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Josbert M. Metselaar
5Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH-Aachen University, Aachen, Germany
Thomas Reinheckel
6Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany
7German Cancer Consortium (DKTK), Freiburg, Germany
8BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University, Freiburg, Germany; and
Peter M. Hoogerbrugge
9Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands
Otto C. Boerman
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Frank N. van Leeuwen
1Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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Journal of Nuclear Medicine
Vol. 58, Issue 2
February 1, 2017
In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman, Frank N. van Leeuwen
Journal of Nuclear Medicine Feb 2017, 58 (2) 214-220; DOI: 10.2967/jnumed.116.177741
In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer, Samantha Y.A. Terry, Dorette S. van Ingen Schenau, Kiki C. Andree, Gerben M. Franssen, Debbie M. Roeleveld, Josbert M. Metselaar, Thomas Reinheckel, Peter M. Hoogerbrugge, Otto C. Boerman, Frank N. van Leeuwen
Journal of Nuclear Medicine Feb 2017, 58 (2) 214-220; DOI: 10.2967/jnumed.116.177741