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Research ArticleSupplement

Evaluation of Prostate Cancer Bone Metastases with 18F-NaF and 18F-Fluorocholine PET/CT

Mohsen Beheshti, Alireza Rezaee, Hans Geinitz, Wolfgang Loidl, Christian Pirich and Werner Langsteger
Journal of Nuclear Medicine October 2016, 57 (Supplement 3) 55S-60S; DOI: https://doi.org/10.2967/jnumed.115.169730
Mohsen Beheshti
1Department of Nuclear Medicine and Endocrinology, PET–CT Center Linz, St. Vincent’s Hospital, Linz, Austria
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Alireza Rezaee
1Department of Nuclear Medicine and Endocrinology, PET–CT Center Linz, St. Vincent’s Hospital, Linz, Austria
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Hans Geinitz
2Department of Radiation Oncology, St. Vincent’s Hospital, Linz, Austria
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Wolfgang Loidl
3Department of Urology, St. Vincent’s Hospital, Linz, Austria; and
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Christian Pirich
4Department of Nuclear Medicine, Paracelsus Private Medical University, Salzburg, Austria
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Werner Langsteger
1Department of Nuclear Medicine and Endocrinology, PET–CT Center Linz, St. Vincent’s Hospital, Linz, Austria
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  • FIGURE 1.
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    FIGURE 1.

    Follow-up 18F-fluorocholine (FCH) PET images of high-risk prostate cancer patient. Suspiciously increased tracer uptake on lumbar spine (upper row left, arrow) without any morphologic change on CT (upper row right, arrow) is suggestive of bone marrow metastasis. Follow-up 18F-fluorocholine scan shows significantly increased tracer uptake on lumbar spine, suggestive of disease progression (lower row left, arrow) corresponding to suspicious sclerotic changes on CT (lower row right, arrow).

  • FIGURE 2.
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    FIGURE 2.

    Comparison of 18F-NaF PET and 18F-fluorocholine (FCH) PET images in prostate cancer patient (prostate-specific antigen level, 72.0 ng/mL; Gleason score, 8) after hormone therapy (1-d interval between 2 studies). 18F-NaF PET image (A) shows markedly more lesions than 18F-fluorocholine PET image (B).

  • FIGURE 3.
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    FIGURE 3.

    Comparison of 18F-fluorocholine (FCH) and 18F-NaF images in high-risk prostate cancer patient after hormone therapy. 18F-NaF PET image shows significantly increased tracer uptake on thoracic spine (upper row left, arrow) corresponding to highly suspicious, densely sclerotic lesion on CT (upper and lower rows right, arrow). 18F-fluorocholine shows only faint uptake on sclerotic lesion (lower row left, arrow).

  • FIGURE 4.
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    FIGURE 4.

    Comparison of 18F-fluorocholine (FCH) and 18F-NaF PET/CT images in prostate cancer patient (prostate-specific antigen level, 7.3 ng/mL; Gleason score, 7). 18F-NaF PET scan shows increased tracer uptake on thoracic spine (upper row left, arrow) corresponding to suspicious sclerotic lesion on CT (upper and lower rows right, arrows). 18F-fluorocholine image shows only faint uptake on rim of sclerotic lesion (lower row left, arrow).

  • FIGURE 5.
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    FIGURE 5.

    18F-NaF PET/CT and 18F-fluorocholine (FCH) PET/CT images in intermediate-risk prostate cancer patient after radiation therapy on vertebral spine (T10). Negative 18F-NaF and 18F-fluorocholine PET images (upper and lower rows left, arrow) correspond to sclerotic lesion on CT (upper and lower rows right, arrow) and are suggestive of nonviable bone metastasis after radiotherapy.

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Journal of Nuclear Medicine: 57 (Supplement 3)
Journal of Nuclear Medicine
Vol. 57, Issue Supplement 3
October 1, 2016
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Evaluation of Prostate Cancer Bone Metastases with 18F-NaF and 18F-Fluorocholine PET/CT
Mohsen Beheshti, Alireza Rezaee, Hans Geinitz, Wolfgang Loidl, Christian Pirich, Werner Langsteger
Journal of Nuclear Medicine Oct 2016, 57 (Supplement 3) 55S-60S; DOI: 10.2967/jnumed.115.169730

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Evaluation of Prostate Cancer Bone Metastases with 18F-NaF and 18F-Fluorocholine PET/CT
Mohsen Beheshti, Alireza Rezaee, Hans Geinitz, Wolfgang Loidl, Christian Pirich, Werner Langsteger
Journal of Nuclear Medicine Oct 2016, 57 (Supplement 3) 55S-60S; DOI: 10.2967/jnumed.115.169730
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  • Article
    • Abstract
    • 18F-FLUOROCHOLINE PET/CT
    • 18F-FLUOROCHOLINE PET/MRI
    • 18F-NAF PET/CT
    • COMPARISON OF 18F-NAF WITH 18F-FLUOROCHOLINE PET/CT
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Keywords

  • prostate cancer
  • bone metastasis
  • 18F-NaF PET/CT
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