Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology

My Jonasson; Anders Wall; Konstantinos Chiotis; Laure Saint-Aubert; Helena Wilking; Margareta Sprycha; Beatrice Borg; Alf Thibblin; Jonas Eriksson; Jens Sörensen; Gunnar Antoni; Agneta Nordberg; Mark Lubberink

doi:10.2967/jnumed.115.158519

Research ArticleClinical Investigations

Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology

My Jonasson, Anders Wall, Konstantinos Chiotis, Laure Saint-Aubert, Helena Wilking, Margareta Sprycha, Beatrice Borg, Alf Thibblin, Jonas Eriksson, Jens Sörensen, Gunnar Antoni, Agneta Nordberg and Mark Lubberink

Journal of Nuclear Medicine April 2016, 57 (4) 574-581; DOI: https://doi.org/10.2967/jnumed.115.158519

My Jonasson

1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

2Medical Physics, Uppsala University Hospital, Uppsala, Sweden

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Anders Wall

1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Konstantinos Chiotis

4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden

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Laure Saint-Aubert

4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden

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Helena Wilking

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Margareta Sprycha

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Beatrice Borg

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Alf Thibblin

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Jonas Eriksson

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

5Pre-clinical PET Platform, Uppsala University, Uppsala, Sweden; and

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Jens Sörensen

1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

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Gunnar Antoni

3PET Centre, Uppsala University Hospital, Uppsala, Sweden

5Pre-clinical PET Platform, Uppsala University, Uppsala, Sweden; and

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Agneta Nordberg

4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden

6Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

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Mark Lubberink

1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

2Medical Physics, Uppsala University Hospital, Uppsala, Sweden

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Journal of Nuclear Medicine

Vol. 57, Issue 4

April 1, 2016

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Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology

Journal of Nuclear Medicine Apr 2016, 57 (4) 574-581; DOI: 10.2967/jnumed.115.158519

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Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology

Journal of Nuclear Medicine Apr 2016, 57 (4) 574-581; DOI: 10.2967/jnumed.115.158519

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Keywords

positron emission tomography
kinetic modeling
Parametric images
Alzheimer’s disease
tau

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