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Research ArticleClinical Investigations

Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology

My Jonasson, Anders Wall, Konstantinos Chiotis, Laure Saint-Aubert, Helena Wilking, Margareta Sprycha, Beatrice Borg, Alf Thibblin, Jonas Eriksson, Jens Sörensen, Gunnar Antoni, Agneta Nordberg and Mark Lubberink
Journal of Nuclear Medicine April 2016, 57 (4) 574-581; DOI: https://doi.org/10.2967/jnumed.115.158519
My Jonasson
1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
2Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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Anders Wall
1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Konstantinos Chiotis
4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
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Laure Saint-Aubert
4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
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Helena Wilking
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Margareta Sprycha
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Beatrice Borg
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Alf Thibblin
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Jonas Eriksson
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
5Pre-clinical PET Platform, Uppsala University, Uppsala, Sweden; and
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Jens Sörensen
1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
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Gunnar Antoni
3PET Centre, Uppsala University Hospital, Uppsala, Sweden
5Pre-clinical PET Platform, Uppsala University, Uppsala, Sweden; and
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Agneta Nordberg
4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
6Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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Mark Lubberink
1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
2Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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Article Information

vol. 57 no. 4 574-581
DOI 
https://doi.org/10.2967/jnumed.115.158519
PubMed 
26795290

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication April 1, 2015
  • Accepted for publication November 19, 2015
  • Published online April 1, 2016.

Article Versions

  • previous version (January 21, 2016 - 05:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. My Jonasson1,2,
  2. Anders Wall1,3,
  3. Konstantinos Chiotis4,
  4. Laure Saint-Aubert4,
  5. Helena Wilking3,
  6. Margareta Sprycha3,
  7. Beatrice Borg3,
  8. Alf Thibblin3,
  9. Jonas Eriksson3,5,
  10. Jens Sörensen1,3,
  11. Gunnar Antoni3,5,
  12. Agneta Nordberg4,6 and
  13. Mark Lubberink1,2
  1. 1Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  2. 2Medical Physics, Uppsala University Hospital, Uppsala, Sweden
  3. 3PET Centre, Uppsala University Hospital, Uppsala, Sweden
  4. 4Translational Alzheimer Neurobiology, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
  5. 5Pre-clinical PET Platform, Uppsala University, Uppsala, Sweden; and
  6. 6Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
  1. For correspondence or reprints contact: Agneta Nordberg, Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Novum, 141 57 Huddinge, Sweden. E-mail: agneta.k.nordberg{at}ki.se
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Journal of Nuclear Medicine: 57 (4)
Journal of Nuclear Medicine
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April 1, 2016
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Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology
My Jonasson, Anders Wall, Konstantinos Chiotis, Laure Saint-Aubert, Helena Wilking, Margareta Sprycha, Beatrice Borg, Alf Thibblin, Jonas Eriksson, Jens Sörensen, Gunnar Antoni, Agneta Nordberg, Mark Lubberink
Journal of Nuclear Medicine Apr 2016, 57 (4) 574-581; DOI: 10.2967/jnumed.115.158519

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Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology
My Jonasson, Anders Wall, Konstantinos Chiotis, Laure Saint-Aubert, Helena Wilking, Margareta Sprycha, Beatrice Borg, Alf Thibblin, Jonas Eriksson, Jens Sörensen, Gunnar Antoni, Agneta Nordberg, Mark Lubberink
Journal of Nuclear Medicine Apr 2016, 57 (4) 574-581; DOI: 10.2967/jnumed.115.158519
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Keywords

  • Positron Emission Tomography
  • kinetic modeling
  • Parametric images
  • Alzheimer’s disease
  • tau
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