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Journal of Nuclear Medicine

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Research ArticleClinical Investigations

First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake

Neeta Pandit-Taskar, Joseph A. O’Donoghue, Shutian Ruan, Serge K. Lyashchenko, Jorge A. Carrasquillo, Glenn Heller, Danny F. Martinez, Sarah M. Cheal, Jason S. Lewis, Martin Fleisher, Jennifer S. Keppler, Robert E. Reiter, Anna M. Wu, Wolfgang A. Weber, Howard I. Scher, Steven M. Larson and Michael J. Morris
Journal of Nuclear Medicine December 2016, 57 (12) 1858-1864; DOI: https://doi.org/10.2967/jnumed.116.176206
Neeta Pandit-Taskar
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
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Joseph A. O’Donoghue
3Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
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Shutian Ruan
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
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Serge K. Lyashchenko
4Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
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Jorge A. Carrasquillo
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
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Glenn Heller
5Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
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Danny F. Martinez
6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
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Sarah M. Cheal
7Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
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Jason S. Lewis
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
4Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
7Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
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Martin Fleisher
8Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
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Jennifer S. Keppler
9ImaginAb, Inc., Inglewood, California; and
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Robert E. Reiter
9ImaginAb, Inc., Inglewood, California; and
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Anna M. Wu
9ImaginAb, Inc., Inglewood, California; and
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Wolfgang A. Weber
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
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Howard I. Scher
6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
10Department of Medicine, Weill Cornell Medical College, New York, New York
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Steven M. Larson
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
7Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
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Michael J. Morris
6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
10Department of Medicine, Weill Cornell Medical College, New York, New York
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Journal of Nuclear Medicine: 57 (12)
Journal of Nuclear Medicine
Vol. 57, Issue 12
December 1, 2016
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First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake
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First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake
Neeta Pandit-Taskar, Joseph A. O’Donoghue, Shutian Ruan, Serge K. Lyashchenko, Jorge A. Carrasquillo, Glenn Heller, Danny F. Martinez, Sarah M. Cheal, Jason S. Lewis, Martin Fleisher, Jennifer S. Keppler, Robert E. Reiter, Anna M. Wu, Wolfgang A. Weber, Howard I. Scher, Steven M. Larson, Michael J. Morris
Journal of Nuclear Medicine Dec 2016, 57 (12) 1858-1864; DOI: 10.2967/jnumed.116.176206

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First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake
Neeta Pandit-Taskar, Joseph A. O’Donoghue, Shutian Ruan, Serge K. Lyashchenko, Jorge A. Carrasquillo, Glenn Heller, Danny F. Martinez, Sarah M. Cheal, Jason S. Lewis, Martin Fleisher, Jennifer S. Keppler, Robert E. Reiter, Anna M. Wu, Wolfgang A. Weber, Howard I. Scher, Steven M. Larson, Michael J. Morris
Journal of Nuclear Medicine Dec 2016, 57 (12) 1858-1864; DOI: 10.2967/jnumed.116.176206
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  • Single Chelator-Minibody Theranostic Agents for 89Zr PET Imaging and 177Lu Radiopharmaceutical Therapy of PSMA-Expressing Prostate Cancer
  • Antibody Engineering for Nuclear Imaging and Radioimmunotherapy
  • CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody
  • 11C Dosimetry Scans Should Be Abandoned
  • First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting
  • Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
  • Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using 89Zr-DFO-MSTP2109A Anti-STEAP1 Antibody
  • Dosimetry of 177Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer: Correlations Between Pretherapeutic Imaging and Whole-Body Tumor Dosimetry with Treatment Outcomes
  • A Perspective on the Evolving Story of PSMA Biology, PSMA-Based Imaging, and Endoradiotherapeutic Strategies
  • Long-Half-Life 89Zr-Labeled Radiotracers Can Guide Percutaneous Biopsy Within the PET/CT Suite Without Reinjection of Radiotracer
  • Immune Modulation Therapy and Imaging: Workshop Report
  • Why Targeting PSMA Is a Game Changer in the Management of Prostate Cancer
  • Pharmacokinetics, Biodistribution, and Radiation Dosimetry for 89Zr-Trastuzumab in Patients with Esophagogastric Cancer
  • Targeted {alpha}-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding
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Keywords

  • 89Zr- IAB2M
  • minibody
  • PSMA
  • prostate cancer imaging
  • dosimetry
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