Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleClinical Investigations

Metabolic PET/CT-Guided Lung Lesion Biopsies: Impact on Diagnostic Accuracy and Rate of Sampling Error

Ludmila Guralnik, Radu Rozenberg, Alex Frenkel, Ora Israel and Zohar Keidar
Journal of Nuclear Medicine April 2015, 56 (4) 518-522; DOI: https://doi.org/10.2967/jnumed.113.131466
Ludmila Guralnik
1Department of Radiology, Rambam Health Care Campus, Haifa, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Radu Rozenberg
1Department of Radiology, Rambam Health Care Campus, Haifa, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex Frenkel
2Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ora Israel
2Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; and
3B & R Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zohar Keidar
2Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; and
3B & R Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    TP CT-guided FNA in 44 × 42 mm lesion in left lung: CT FNA demonstrating location of aspirating needle (arrow) (A), registered CT FNA slice with corresponding PET/CT image (red contours, score 1) (B), and corresponding 18F-FDG PET slice demonstrating high and homogeneous 18F-FDG uptake at site of needle tip (C). SUVmax at tip of needle: 9.1; highest SUVmax in tumor: 11.0, distance between tumor SUVmax and tip of needle: 3.77 mm; FNA results: adenocarcinoma; histologic sample obtained at surgery: poorly differentiated adenocarcinoma.

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    FN CT-guided FNA in 58 × 37 mm lesion in left lung: CT FNA demonstrating location of aspirating needle (arrow) (A), registered CT FNA slice with corresponding PET/CT image (red contours, score 2) (B), and corresponding 18F-FDG PET slice demonstrating that tip of needle is inside area of lesion with low metabolic activity (C). SUVmax at tip of needle: 2.4; highest SUVmax in tumor: 6.9; distance between tumor SUVmax and tip of needle: 11.85 mm; FNA results: macrophages and respiratory cells; histologic sample obtained at surgery: moderately differentiated squamous cell carcinoma.

Tables

  • Figures
    • View popup
    TABLE 1

    Morphologic and Metabolic Lesion Characteristics in Cases with TP and FN FNA Results

    CharacteristicTPFNP
    No. of patients17934
    Size of lesion (mm)NS
     Average35.229.8
     Minimum6.59
     Maximum100148
    PET uptake pattern (%)NS
     Homogeneous70 (39%)16 (47%)
     Inhomogeneous102 (57%)14 (41%)NS
     Absent7 (4%)4 (12%)NS
    SUVmax at needle tip<0.05
     Average6.44
     Minimum0.30.22
     Maximum44.722.1
    Lesion SUVmax<0.05
     Average12.49.3
     Minimum0.840.3
     Maximum63.729.8
    Distance from needle tip to highest tumor SUVmax (mm)<0.001
     Average5.915.4
     Minimum00
     Maximum8650.3
    Adenocarcinoma102 (56%)13 (38%)
    Squamous cell carcinoma24 (13%)5 (15%)
    Small cell lung cancer3 (2%)1 (3%)
    Non–small cell lung cancer*28 (15%)1 (3%)
    Neuroendocrine tumor4 (2%)7 (20.5%)
    Other malignancies†21 (12%)7 (20.5%)
    • ↵* No surgery was performed.

    • ↵† Metastases, lymphomas, and nonspecific malignant cells.

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 56 (4)
Journal of Nuclear Medicine
Vol. 56, Issue 4
April 1, 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Metabolic PET/CT-Guided Lung Lesion Biopsies: Impact on Diagnostic Accuracy and Rate of Sampling Error
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Metabolic PET/CT-Guided Lung Lesion Biopsies: Impact on Diagnostic Accuracy and Rate of Sampling Error
Ludmila Guralnik, Radu Rozenberg, Alex Frenkel, Ora Israel, Zohar Keidar
Journal of Nuclear Medicine Apr 2015, 56 (4) 518-522; DOI: 10.2967/jnumed.113.131466

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Metabolic PET/CT-Guided Lung Lesion Biopsies: Impact on Diagnostic Accuracy and Rate of Sampling Error
Ludmila Guralnik, Radu Rozenberg, Alex Frenkel, Ora Israel, Zohar Keidar
Journal of Nuclear Medicine Apr 2015, 56 (4) 518-522; DOI: 10.2967/jnumed.113.131466
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • PET/CT-Guided Biopsy of Suspected Lung Lesions Requires Less Rebiopsy Than CT-Guided Biopsy Due to Inconclusive Results
  • Interventional Molecular Imaging
  • Google Scholar

More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  • Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
Show more Clinical Investigations

Similar Articles

Keywords

  • biopsy
  • PET/CT
  • lung
  • CT-guided biopsy
SNMMI

© 2025 SNMMI

Powered by HighWire