Amyloid imaging in dementia: Frey provides perspectives on key questions about the utility of amyloid imaging in dementia diagnosis and previews an article in this issue of JNM on 18F-florbetapir PET in this setting.
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99mTc-MAA uptake before radioembolization: Ilhan and colleagues evaluate variations in 99mTc-macroaggregated albumin uptake in primary and secondary liver tumors before 90Y radioembolization in a large and diverse cohort of oncology patients.
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Personalized radioembolization in PVT: Garin and colleagues investigate the effects of a personalized dosimetry and intensification concept on response and survival rates in patients with hepatocellular carcinoma portal vein thrombosis treated with 90Y-loaded glass microspheres.
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DOTATATE PET in meningiomas: Rachinger and colleagues report on a study correlating 68Ga-DOTATATE uptake on PET, somatostatin receptor 2 expression, and histology (including tumor-free scar tissue) in patients with primary or recurrent meningiomas.
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PET and CRPC response: Yu and colleagues describe the results of a trial exploring the ability of 18F-fluoride PET to delineate treatment response to dasatinib in castrate-resistant prostate cancer bone metastases and to predict progression-free survival.
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Integrin PET imaging of renal masses: Withofs and colleagues identify correlations between uptake of 18F-FPRGD2, an RGD peptide, and both integrin αvβ3 expression and angiogenesis in renal tumors.
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Quantification of 18F-fluorocholine uptake: Verwer and colleagues use pharmacokinetic modeling to validate the application of simplified methods for quantification of 18F-fluoromethylcholine uptake in routine clinical PET imaging.
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18F-bombesin PET/CT in prostate cancer: Sah and colleagues detail a study of the feasibility, safety, tolerability, and dosimetric and imaging properties of the bombesin analog BAY 864367 for PET/CT in a small patient group with primary and recurrent prostate cancer.
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PET/CT acquisition timing in neurofibromatosis: Chirindel and colleagues compare the effectiveness of early and delayed 18F-FDG PET/CT imaging in differentiating malignant peripheral nerve sheath tumors from benign neurofibromas in patients with neurofibromatosis type 1.
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18F-florbetapir PET in FTD and AD: Kobylecki and colleagues describe a PET study using 18F-florbetapir PET to assess amyloid β in healthy controls and patients with frontotemporal dementia and Alzheimer disease.
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Mapping brain α2 adrenoceptors: Nahimi and colleagues determine blood–brain clearances, volumes of distribution, and receptor availability in PET with 11C-yohimbine, a selective α2-adrenoceptor antagonist, in healthy men.
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Prefrontal hypometabolism in AD: Klupp and colleagues use 11C-PiB and 18F-FDG PET and MR imaging to explore locoregional and remote relationships between prefrontal metabolism and longitudinal amyloid increase, illuminating linking mechanisms between pathology and dysfunction in Alzheimer disease.
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68Ga-EDTA PET–assessed GFR: Hofman and colleagues compare agreement between glomerular filtration rates derived from 51Cr-EDTA plasma clearance and from 68Ga-EDTA PET/CT camera-based renal imaging and quantitation of clearance of activity from blood and its appearance in the urine.
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68Ga-pentixafor dosimetry: Herrmann and colleagues detail whole-body distribution and radiation dosimetry of this promising PET tracer for imaging expression of the human chemokine receptor 4 in a small group of patients with multiple myeloma.
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Clinical evaluation of single-echo ZTE: Delso and colleagues assess a novel, recently published method for zero-echo-time–based MR bone depiction and segmentation in the skull that could be used to provide high-resolution maps of bone tissue with anatomic accuracy.
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PET/MR-based attenuation correction: Cabello and colleagues present a fully automatic method to estimate attenuation correction maps for quantitative PET reconstruction, including bone tissue, using only MR information.
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18F-fluoride PET/MR in foot pain: Rauscher and colleagues compare the quality and diagnostic performance of 18F-fluoride PET/MR imaging with that of 18F-fluoride PET/CT in patients with foot pain of unclear cause.
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PET and MR in gynecologic cancer: Lee and colleagues provide an educational overview of the complementary roles of pelvic MR imaging and 18F-FDG PET/CT in the care of gynecologic cancer patients and the potential of PET/MR imaging this setting.
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Cerenkov imaging for therapy monitoring: Timmermand and colleagues investigate Cerenkov luminescence imaging as a tool for deriving key dosimetric parameters in radionuclide therapy in ex and in vivo animal studies.
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Imaging tumor-associated monocytes: Becker and colleagues assess alarmin S100A9, implicated in induction of tumor-associated macrophages and myeloid-derived suppressor cells, as a molecular imaging marker for activity of tumor-associated immune cells in a murine breast cancer model.
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PET and MR in post-MI assessment: Lautamaki and colleagues use multiple tomographic imaging techniques to explore cardiac sympathetic neuronal pathology after myocardial infarction in a porcine model.
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Dynamic myocardial innervation analysis: Giorgetti and colleagues describe a 3D approach with a cadmium-zinc-telluride camera to clarify the normal myocardial kinetics of 123I-MIBG over time in an animal model.
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Ultra-high-sensitivity mouse SPECT: Ivashchenko and colleagues detail the development and potential applications of a dedicated ultra-high-sensitivity pinhole SPECT apparatus with very fast time resolution and the capability to image submegabecquerel tracer amounts.
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Parallel-cone collimator for SPECT: Beijst and colleagues present a parallel-hole collimator with cone-shaped holes, designed to limit collimator penetration while preserving resolution and sensitivity in SPECT imaging using high-energy photon-emitting isotopes.
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In vivo pH detection by Cerenkov imaging: Czupryna and colleagues report on the design, testing, and in vivo application of pH-sensitive contrast agents designed specifically for Cerenkov imaging.
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18F-FPEB via an iodonium ylide: Stephenson and colleagues describe a 1-step, regioselective, metal-free 18F-labeling method that uses a hypervalent iodonium(III) ylide precursor to prepare 18F-FPEB for PET imaging.
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- © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.