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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation

Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel and Brenda M. Sandmaier
Journal of Nuclear Medicine November 2015, 56 (11) 1766-1773; DOI: https://doi.org/10.2967/jnumed.115.162388
Sofia H.L. Frost
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Brian W. Miller
2Pacific Northwest National Laboratory, Richland, Washington
3College of Optical Sciences, University of Arizona, Tucson, Arizona
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Tom A. Bäck
4Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Erlinda B. Santos
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Donald K. Hamlin
5Department of Radiation Oncology, University of Washington, Seattle, Washington
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Sue E. Knoblaugh
6Comparative Medicine Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington; and
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Shani L. Frayo
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Aimee L. Kenoyer
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Rainer Storb
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Oliver W. Press
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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D. Scott Wilbur
5Department of Radiation Oncology, University of Washington, Seattle, Washington
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John M. Pagel
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Brenda M. Sandmaier
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Journal of Nuclear Medicine: 56 (11)
Journal of Nuclear Medicine
Vol. 56, Issue 11
November 1, 2015
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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation
Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel, Brenda M. Sandmaier
Journal of Nuclear Medicine Nov 2015, 56 (11) 1766-1773; DOI: 10.2967/jnumed.115.162388

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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation
Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel, Brenda M. Sandmaier
Journal of Nuclear Medicine Nov 2015, 56 (11) 1766-1773; DOI: 10.2967/jnumed.115.162388
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Cited By...

  • The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapy
  • 211At-Labeled Anti-CD45 Antibody as a Nonmyeloablative Conditioning for Canine DLA-Haploidentical Stem Cell Transplantation
  • Impact of Donor Type in Patients with AML Given Allogeneic Hematopoietic Cell Transplantation After Low-Dose TBI-Based Regimen
  • Cure of Human Ovarian Carcinoma Solid Xenografts by Fractionated {alpha}-Radioimmunotherapy with 211At-MX35-F(ab')2: Influence of Absorbed Tumor Dose and Effect on Long-Term Survival
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Keywords

  • radioimmunotherapy
  • 211At
  • Alpha imaging
  • CD45
  • lymphoma
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