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Research ArticleBasic Science Investigations

α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation

Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel and Brenda M. Sandmaier
Journal of Nuclear Medicine November 2015, 56 (11) 1766-1773; DOI: https://doi.org/10.2967/jnumed.115.162388
Sofia H.L. Frost
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Brian W. Miller
2Pacific Northwest National Laboratory, Richland, Washington
3College of Optical Sciences, University of Arizona, Tucson, Arizona
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Tom A. Bäck
4Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Erlinda B. Santos
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Donald K. Hamlin
5Department of Radiation Oncology, University of Washington, Seattle, Washington
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Sue E. Knoblaugh
6Comparative Medicine Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington; and
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Shani L. Frayo
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Aimee L. Kenoyer
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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Rainer Storb
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Oliver W. Press
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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D. Scott Wilbur
5Department of Radiation Oncology, University of Washington, Seattle, Washington
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John M. Pagel
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Brenda M. Sandmaier
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
7Department of Medicine, University of Washington, Seattle, Washington
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Article Information

vol. 56 no. 11 1766-1773
DOI 
https://doi.org/10.2967/jnumed.115.162388
PubMed 
26338894

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 16, 2015
  • Accepted for publication August 20, 2015
  • Published online November 2, 2015.

Article Versions

  • previous version (September 3, 2015 - 06:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Sofia H.L. Frost1,
  2. Brian W. Miller2,3,
  3. Tom A. Bäck4,
  4. Erlinda B. Santos1,
  5. Donald K. Hamlin5,
  6. Sue E. Knoblaugh6,
  7. Shani L. Frayo1,
  8. Aimee L. Kenoyer1,
  9. Rainer Storb1,7,
  10. Oliver W. Press1,7,
  11. D. Scott Wilbur5,
  12. John M. Pagel1,7 and
  13. Brenda M. Sandmaier1,7
  1. 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
  2. 2Pacific Northwest National Laboratory, Richland, Washington
  3. 3College of Optical Sciences, University of Arizona, Tucson, Arizona
  4. 4Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  5. 5Department of Radiation Oncology, University of Washington, Seattle, Washington
  6. 6Comparative Medicine Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington; and
  7. 7Department of Medicine, University of Washington, Seattle, Washington
  1. For correspondence or reprints contact: Sofia H.L. Frost, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., P.O. Box 19024, Seattle, WA 98109-1024. E-mail: sfrost{at}fredhutch.org
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Journal of Nuclear Medicine: 56 (11)
Journal of Nuclear Medicine
Vol. 56, Issue 11
November 1, 2015
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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation
Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel, Brenda M. Sandmaier
Journal of Nuclear Medicine Nov 2015, 56 (11) 1766-1773; DOI: 10.2967/jnumed.115.162388

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α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation
Sofia H.L. Frost, Brian W. Miller, Tom A. Bäck, Erlinda B. Santos, Donald K. Hamlin, Sue E. Knoblaugh, Shani L. Frayo, Aimee L. Kenoyer, Rainer Storb, Oliver W. Press, D. Scott Wilbur, John M. Pagel, Brenda M. Sandmaier
Journal of Nuclear Medicine Nov 2015, 56 (11) 1766-1773; DOI: 10.2967/jnumed.115.162388
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  • The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapy
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  • Cure of Human Ovarian Carcinoma Solid Xenografts by Fractionated {alpha}-Radioimmunotherapy with 211At-MX35-F(ab')2: Influence of Absorbed Tumor Dose and Effect on Long-Term Survival
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Keywords

  • radioimmunotherapy
  • 211At
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