Research ArticleBasic Science Investigations

VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET

Marlies C. Goorden, Frans van der Have, Rob Kreuger, Ruud M. Ramakers, Brendan Vastenhouw, J. Peter H. Burbach, Jan Booij, Carla F.M. Molthoff and Freek J. Beekman
Journal of Nuclear Medicine February 2013, 54 (2) 306-312; DOI: https://doi.org/10.2967/jnumed.112.109538

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Integration of clustered-pinhole collimator into existing SPECT/CT platform. (A) Traditional pinhole with opening angle α and cluster of 4 pinholes with approximately same field of view and opening angle α/2. (B) Clustered-pinhole collimator optimized for imaging SPECT and PET tracers, into which mouse is placed. (C) Collimator mounted in SPECT/CT system.

  • FIGURE 2.
    FIGURE 2.

    Simultaneously acquired images of SPECT and PET tracers in phantom with 6 segments with capillary diameters of 0.85, 0.80, 0.75, 0.55, 0.50, and 0.45 mm. At start of this scan, capillaries contained 14 MBq of 18F solution and 8.3 MBq of 99mTc solution. Phantom was imaged for 60 min. All images shown had slice thickness of 3.2 mm.

  • FIGURE 3.
    FIGURE 3.

    Simultaneous SPECT/PET cardiac scan. We imaged mouse, injected with 130 MBq of 99mTc-tetrofosmin and 24 MBq of 18F-FDG, for 60 min. Here, we show 3 mutually perpendicular slices through mouse’s heart. Images represent average over cardiac cycle. Supplemental Video 1, of beating heart, was reconstructed from same scan.

  • FIGURE 4.
    FIGURE 4.

    Simultaneously acquired SPECT/PET mouse brain images (color) overlayed on CT (gray). Coronal (A), sagittal (B), and horizontal (C) slices at identical levels are shown. Mouse was injected with 30 MBq of 123I-FP-CIT and 40 MBq of 18F-FDG and imaged for 60 min starting 105 min after injection. Uptake of 123I-FP-CIT (SPECT, top) in small brain structures such as striatum (1), olfactory tubercle (2), and Harderian glands (3) can be resolved. 18F-FDG (PET scan, bottom) is seen in multiple structures, including olfactory bulbs (4), cerebral cortex (5), and thalamic and midbrain areas (6).

  • FIGURE 5.
    FIGURE 5.

    Example of simultaneous SPECT/PET scan obtained with 2 tracers that target same biologic function. Images represent MIPs of mouse injected with 2 bone tracers, 220 MBq of 99mTc-HDP (top) and 60 MBq of 18F-fluoride (bottom), and scanned for 60 min. Supplemental Video 2 shows rotating MIPs.

  • FIGURE 6.
    FIGURE 6.

    Example of simultaneous SPECT/PET bone scan of lumbar spine and pelvis. MIPs of mouse injected with 130 MBq of 99mTc-HDP (top) and 85 MBq of 18F-fluoride (bottom) and scanned for 30 min are shown. Supplemental Video 3 shows rotating MIPs.

Tables

  • TABLE 1

    Measured Peak Sensitivity for 99mTc and 18F

    Sensitivity
    Photopeak window width99mTc18F
    30%0.25%0.31%
    25%0.25%0.30%
    20%0.24%0.29%
    15%0.22%0.28%

Additional Files

Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords