Molecular imaging with reporter genes: Brader and colleagues offer perspectives on radionuclide-based reporter gene imaging as developed and applied in preclinical and clinical studies.
18F−/18F-FDG PET/CT: Cook previews an article in this issue of JNM on the effectiveness of coinjection of these tracers in PET/CT imaging of patients with cancer and possible skeletal metastases.
18F-fluoride and 18F-FDG PET/CT: Iagaru and colleagues report on the use of combined 18F−/18F-FDG in a single PET/CT examination for evaluation of cancer patients and compare the results with those from separate 18F− and 18F-FDG PET/CT imaging.
PET in primary CNS lymphoma: Kasenda and colleagues investigate the prognostic utility of pretreatment 18F-FDG PET in patients with primary central nervous system lymphoma.
Dual-tracer PET/CT and liver transplantation: Cheung and colleagues compare the effectiveness of 11C-acetate and 18F-FDG PET/CT with that of contrast CT in selecting patients with hepatocellular carcinoma for liver transplantation on the basis of the Milan criteria.
18F-FMISO PET reproducibility: Okamoto and colleagues assess the reproducibility of tumor hypoxia by using quantitative analysis of 18F-FMISO uptake in patients with untreated head and neck cancer.
Visualization of brown adipose tissue: Admiraal and colleagues look at the feasibility of and incremental information provided by combined 123I-MIBG SPECT/CT and 18F-FDG PET/CT imaging of brown adipose tissue activity in humans during cold exposure.
11C-PIB PET and cardiac amyloid: Antoni and colleagues explore the use of 11C-PIB PET as a specific diagnostic for cardiac amyloidosis in patients with systemic amyloidosis.
Fully automated cardiac SPECT: Arsanjani and colleagues compare the performance of fully automated quantification of attenuation-corrected and noncorrected myocardial perfusion SPECT with the corresponding performance of experienced readers in detection of coronary artery disease.
18F-FET PET in cerebral lesions: Rapp and colleagues assess the clinical value of 18F-FET PET in the initial diagnosis of cerebral lesions suggestive of glioma.
Tissue density and 3D dosimetry: Dieudonné and colleagues evaluate the impact of tissue density heterogeneities on dosimetry when using a dose kernel convolution method in absorbed dose calculations in molecular radionuclide therapy and propose a density correction method.
18F-labeled agent for islet imaging: Wu and colleagues describe the development of and initial studies with an 18F-labeled exendin-4 PET agent with high specific activity for islet imaging targeting the glucagonlike peptide-1 receptor.
Metformin and tumor metabolism: Habibollahi and colleagues investigate this antidiabetes drug as a central cellular energy sensor and explore the effects on glucose uptake as well as on 18F-FDG and 18F-FLT PET in assessing its effectiveness as an antineoplastic agent.
Metformin and gut metabolism: Massollo and colleagues conduct animal studies designed to explain the mechanisms that result in high bowel radioactivity in 18F-FDG PET staging of abdominal cancer lesions in patients on metformin treatment.
PET for functional analysis of BCRP: Takashima and colleagues describe a quantitative 11C-labeled PET method for assessing hepatobiliary and renal excretion of a breast cancer resistance protein substrate in mice.
Cardiac endothelin receptor PET: Higuchi and colleagues determine the feasibility of using an 18F-labeled ligand for imaging the endothelin subtype-A receptor in healthy and injured rat heart.
15O gas PET in rats: Watabe and colleagues detail the use of the 15O gas steady-state inhalation method for normal anesthetized rats and resulting PET assessments of cerebral blood flow, cerebral metabolic rate, oxygen extraction fraction, and cerebral blood volume.
PET and TSPO in EAE: Mattner and colleagues use 18F-PBR111, with high affinity and selectivity for the translocator protein, in a small-animal PET investigation of neuroinflammation at different phases of relapsing–remitting experimental autoimmune encephalomyelitis.
Synthesis and evaluation of 18F-FE-PEO: Riss and colleagues describe the development of and early studies with this 18F-labeled opioid receptor agonist as a candidate PET tracer with specific advantages over 11C-labeled agonist radiotracers in the brain.
Simultaneous submillimeter SPECT and PET: Goorden and colleagues introduce a versatile-emission CT system for radionuclides that enables simultaneous submillimeter imaging of single-photon and positron-emitting radiolabeled molecules.
Future of 99mTc: Pillai and colleagues discuss strategies to sustain the availability of 99mTc without the use of highly enriched uranium, as well as scientific, economic, and other factors likely to affect medical access to this vital molecular imaging component.
ON THE COVER
11C-PIB PET has shown promise in the specific identification of cardiac amyloid deposits. Uptake is obvious in the left ventricular wall of patients.
See page 213.
- © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
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