Research ArticleBasic Science Investigations

PET of Tumors Expressing Gastrin-Releasing Peptide Receptor with an 18F-Labeled Bombesin Analog

Ingrid Dijkgraaf, Gerben M. Franssen, William J. McBride, Christopher A. D’Souza, Peter Laverman, Charles J. Smith, David M. Goldenberg, Wim J.G. Oyen and Otto C. Boerman
Journal of Nuclear Medicine June 2012, 53 (6) 947-952; DOI: https://doi.org/10.2967/jnumed.111.100891

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Structural formula of NOTA-conjugated BBN analog NOTA-8-Aoc-BBN(7-14)NH2.

  • FIGURE 2.
    FIGURE 2.

    Radio-HPLC chromatograms of 18F- (top) and 68Ga-labeled (bottom) NOTA-8-Aoc-BBN(7-14)NH2.

  • FIGURE 3.
    FIGURE 3.

    Competition of specific binding of 111In-NOTA-8-Aoc-BBN(7-14)NH2 with various NOTA-8-Aoc-BBN(7-14)NH2 analogs.

  • FIGURE 4.
    FIGURE 4.

    (A) Biodistribution of 18F-NOTA-8-Aoc-BBN(7-14)NH2 at 1 h after injection in athymic mice with subcutaneous PC-3 tumors in absence (5 mice per group) or presence (2 mice per group) of excess of nonradiolabeled NOTA-8-Aoc-BBN(7-14)NH2. (B) Biodistribution of 68Ga-NOTA-8-Aoc-BBN(7-14)NH2 at 1 h after injection in athymic mice with subcutaneous PC-3 tumors in absence (6 mice per group) or presence (3 mice per group) of excess of nonradiolabeled NOTA-8-Aoc-BBN(7-14)NH2. p.i. = after injection; xs = excess.

  • FIGURE 5.
    FIGURE 5.

    3-dimensional volume–rendering projections of fused PET and CT scans of mice with subcutaneously growing PC-3 tumor after intravenous injection of 18F-NOTA-8-Aoc-BBN(7-14)NH2 in absence (A) or presence (B) of excess of nonradiolabeled NOTA-8-Aoc-BBN(7-14)NH2. Scans were recorded at 1 h after injection.

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